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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cyclic-nucleotide phosphodiesterase activity
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Accession:GO:0051344 term browser browse the term
Definition:Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
Synonyms:exact_synonym: 3',5' cyclic nucleotide phosphodiesterase inhibitor;   down regulation of cyclic nucleotide phosphodiesterase activity;   downregulation of cyclic nucleotide phosphodiesterase activity;   negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity
 narrow_synonym: 3',5'-cyclic-AMP phosphodiesterase inhibitor;   cAMP phosphodiesterase inhibitor;   inhibition of cyclic nucleotide phosphodiesterase activity;   negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity;   negative regulation of cAMP phosphodiesterase activity;   negative regulation of cGMP phosphodiesterase activity
 related_synonym: phosphodiesterase inhibitor


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negative regulation of cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aip aryl-hydrocarbon receptor-interacting protein JBrowse link 1 219,361,859 219,373,924 RGD:632260
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:8554232
G Rgn regucalcin JBrowse link X 1,833,484 1,848,904 RGD:9590243
G Slc39a14 solute carrier family 39 member 14 JBrowse link 15 51,982,872 52,029,841 RGD:1600115

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  biological_process 19336
    biological regulation 13340
      regulation of molecular function 3020
        regulation of catalytic activity 2300
          regulation of hydrolase activity 1267
            regulation of cyclic-nucleotide phosphodiesterase activity 9
              negative regulation of cyclic-nucleotide phosphodiesterase activity 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.