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ONTOLOGY REPORT - ANNOTATIONS


Term:peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one
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Accession:GO:0051357 term browser browse the term
Definition:The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons.
Comment:Note that this predicted modification is now thought not to exist. See the biological process term 'peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine ; GO:0051359'.
Synonyms:exact_synonym: biosynthesis of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine;   biosynthetic process of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine
 xref: RESID:AA0377


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  biological_process 19334
    metabolic process 11555
      primary metabolic process 10411
        protein metabolic process 5973
          protein modification process 3851
            cellular protein modification process 3851
              peptide cross-linking 34
                peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one 0
Path 2
Term Annotations click to browse term
  biological_process 19334
    metabolic process 11555
      nitrogen compound metabolic process 9892
        organonitrogen compound metabolic process 6852
          protein metabolic process 5973
            protein modification process 3851
              cellular protein modification process 3851
                peptidyl-amino acid modification 1272
                  peptidyl-methionine modification 11
                    peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.