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ONTOLOGY REPORT - ANNOTATIONS


Term:actin filament capping
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Accession:GO:0051693 term browser browse the term
Definition:The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
Synonyms:related_synonym: F-actin capping activity;   actin capping activity


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actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsn gelsolin ISO (PMID:19666531)
(MGI:5619440|PMID:23325791)
RGD PMID:19666531, PMID:23325791 MGI:5619440 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Myh9 myosin, heavy chain 9 NOT ISO (MGI:5619440|PMID:23325791) RGD PMID:23325791 MGI:5619440 NCBI chr 7:118,740,005...118,792,507
Ensembl chr 7:118,741,110...118,792,625
JBrowse link
G Scin scinderin ISO (PMID:19666531) RGD PMID:19666531 NCBI chr 6:59,975,375...60,055,075
Ensembl chr 6:59,976,003...60,054,279
JBrowse link
G Spta1 spectrin, alpha, erythrocytic 1 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:92,264,231...92,340,091
Ensembl chr13:92,264,231...92,340,083
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Sptb spectrin, beta, erythrocytic IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 6:99,657,144...99,783,189
Ensembl chr 6:99,659,651...99,783,047
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr14:114,517,839...114,700,199
Ensembl chr14:114,518,816...114,692,764
JBrowse link
G Sptbn2 spectrin, beta, non-erythrocytic 2 IEA GO_REF:0000104
GO_REF:0000043
UniProt GO_REF:0000043, GO_REF:0000104 NCBI chr 1:219,964,429...220,006,811
Ensembl chr 1:219,964,429...220,005,068
JBrowse link
G Sptbn4 spectrin, beta, non-erythrocytic 4 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:84,168,494...84,254,679
Ensembl chr 1:84,168,495...84,254,645
JBrowse link
G Tpm1 tropomyosin 1 IDA RGD PMID:15779917 RGD:1600523 NCBI chr 8:72,814,737...72,841,496
Ensembl chr 8:72,814,740...72,842,228
JBrowse link
G Tpm1_v7 tropomyosin 1, variant 7 IDA RGD PMID:15779917 RGD:1600523
G Vil1 villin 1 ISO (PMID:16921170), (PMID:17182858), (PMID:19808673) RGD PMID:16921170, PMID:17182858, PMID:19808673 NCBI chr 9:81,689,802...81,717,623
Ensembl chr 9:81,689,802...81,717,621
JBrowse link
barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 4933400A11Rik RIKEN cDNA 4933400A11 gene IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr  X:25,737,292...25,738,155 JBrowse link
G Add1 adducin 1 ISO
IBA
IEA
(PMID:8626479)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:8626479, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr14:81,367,466...81,426,610
Ensembl chr14:81,367,468...81,426,496
JBrowse link
G Add2 adducin 2 ISO
IBA
IEA
(PMID:8626479)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:8626479, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 4:117,691,294...117,887,556
Ensembl chr 4:117,743,710...117,882,464
JBrowse link
G Add3 adducin 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:273,854,195...273,961,982
Ensembl chr 1:273,854,248...273,961,982
JBrowse link
G Avil advillin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:70,292,565...70,310,588
Ensembl chr 7:70,292,565...70,310,588
JBrowse link
G Capg capping actin protein, gelsolin like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:100,395,693...100,419,447
Ensembl chr 4:100,407,658...100,419,446
JBrowse link
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 IBA
ISO
PMID:21873635
(MGI:3758397|PMID:17656356)
RGD PMID:17656356, PMID:21873635 MGI:3758397, RGD:13792537 NCBI chr 2:207,305,748...207,350,812
Ensembl chr 2:207,305,752...207,350,812
JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:44,936,290...44,972,270
Ensembl chr 4:44,936,290...44,972,267
JBrowse link
G Capza3 capping actin protein of muscle Z-line subunit alpha 3 IBA
IEA
PMID:21873635
GO_REF:0000104
UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 4:174,181,644...174,182,857
Ensembl chr 4:174,181,644...174,182,856
JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta IBA
ISO
IEA
PMID:21873635
(MGI:3758397|PMID:17656356)
GO_REF:0000104
RGD
UniProt
PMID:17656356, PMID:21873635 GO_REF:0000104, MGI:3758397, RGD:13792537 NCBI chr 5:157,642,742...157,742,487
Ensembl chr 5:157,642,751...157,742,478
JBrowse link
G Dbnl drebrin-like NOT ISO (MGI:1353214|PMID:10637315) RGD PMID:10637315 MGI:1353214 NCBI chr14:86,029,335...86,044,364
Ensembl chr14:86,029,335...86,044,364
JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 ISS
ISO
GO_REF:0000024
(MGI:4460022|PMID:20532239), (MGI:5476881|PMID:23314863), (MGI:5486559|PMID:15558031)
UniProt
RGD
PMID:15558031, PMID:20532239, PMID:23314863 GO_REF:0000024, MGI:4460022, MGI:5476881, MGI:5486559 NCBI chr 4:171,475,155...171,645,620
Ensembl chr 4:171,475,567...171,591,882
JBrowse link
G Flii FLII, actin remodeling protein IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:46,955,460...46,969,468
Ensembl chr10:46,955,487...46,969,406
JBrowse link
G Gsn gelsolin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Rdx radixin IDA RGD PMID:2500445 RGD:8693627 NCBI chr 8:56,570,728...56,612,851
Ensembl chr 8:56,585,396...56,610,612
JBrowse link
G RGD1563947 similar to RIKEN cDNA 4933400A11 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:25,737,281...25,738,144 JBrowse link
G Scin scinderin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:59,975,375...60,055,075
Ensembl chr 6:59,976,003...60,054,279
JBrowse link
G Svil supervillin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:55,230,298...55,425,967
Ensembl chr17:55,230,298...55,346,279
JBrowse link
G Twf1 twinfilin actin-binding protein 1 IBA
ISO
PMID:21873635
(MGI:3840765|PMID:18837697)
RGD PMID:18837697, PMID:21873635 MGI:3840765, RGD:13792537 NCBI chr 7:135,838,647...135,850,542
Ensembl chr 7:135,838,648...135,850,542
JBrowse link
G Twf2 twinfilin actin-binding protein 2 IBA
ISO
PMID:21873635
(MGI:3840765|PMID:18837697)
RGD PMID:18837697, PMID:21873635 MGI:3840765, RGD:13792537 NCBI chr 8:114,897,011...114,909,531
Ensembl chr 8:114,897,011...114,909,531
JBrowse link
G Vil1 villin 1 ISO
IBA
(PMID:15272027)
PMID:21873635
RGD PMID:15272027, PMID:21873635 RGD:13792537 NCBI chr 9:81,689,802...81,717,623
Ensembl chr 9:81,689,802...81,717,621
JBrowse link
G Vill villin-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:127,735,233...127,753,313
Ensembl chr 8:127,735,258...127,753,349
JBrowse link
negative regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carmil1 capping protein regulator and myosin 1 linker 1 ISO (MGI:3588909|PMID:16054028) RGD PMID:16054028 MGI:3588909 NCBI chr17:43,050,282...43,339,403
Ensembl chr17:43,050,789...43,339,403
JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 ISO (PMID:26466680) RGD PMID:26466680 NCBI chr19:37,652,383...37,665,333
Ensembl chr19:37,652,969...37,668,019
JBrowse link
G Cracd capping protein inhibiting regulator of actin dynamics ISO
IBA
(PMID:30361697)
PMID:21873635
RGD PMID:30361697, PMID:21873635 RGD:13792537 NCBI chr14:33,649,989...33,783,794
Ensembl chr14:33,649,637...33,677,031
JBrowse link
G Washc2c WASH complex subunit 2C ISO (PMID:20498093) RGD PMID:20498093 NCBI chr 4:148,139,512...148,197,363
Ensembl chr 4:148,139,528...148,197,365
JBrowse link
pointed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lmod1 leiomodin 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:52,147,099...52,189,835
Ensembl chr13:52,147,555...52,190,228
JBrowse link
G Lmod2 leiomodin 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:51,553,439...51,561,135
Ensembl chr 4:51,553,454...51,561,174
JBrowse link
G Lmod3 leiomodin 3 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:129,604,378...129,619,136
Ensembl chr 4:129,604,267...129,619,142
JBrowse link
G LOC100909784 leiomodin-2-like IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:51,661,538...51,669,306
Ensembl chr 4:51,661,654...51,671,203
JBrowse link
G Tmod1 tropomodulin 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:61,635,244...61,712,052
Ensembl chr 5:61,657,507...61,712,051
JBrowse link
G Tmod2 tropomodulin 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:82,505,947...82,547,450
Ensembl chr 8:82,506,934...82,533,689
JBrowse link
G Tmod3 tropomodulin 3 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:82,432,165...82,492,243
Ensembl chr 8:82,432,169...82,492,243
JBrowse link
G Tmod4 tropomodulin 4 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:196,294,990...196,299,896
Ensembl chr 2:196,295,069...196,299,896
JBrowse link
positive regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc2 actin related protein 2/3 complex, subunit 2 IMP RGD PMID:15252126 RGD:2306210 NCBI chr 9:81,518,163...81,548,871
Ensembl chr 9:81,518,176...81,548,871
JBrowse link
G Cfl1 cofilin 1 IMP RGD PMID:23704350 RGD:11570555 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtpn myotrophin ISO
IBA
ISS
(PMID:16895918)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:16895918, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 4:63,012,009...63,039,422
Ensembl chr 4:63,012,011...63,039,422
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      negative regulation of cellular process 5156
        negative regulation of cellular component organization 782
          negative regulation of supramolecular fiber organization 175
            negative regulation of actin filament depolymerization 52
              actin filament capping 46
                barbed-end actin filament capping + 29
                pointed-end actin filament capping 8
Path 2
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          organelle organization 4101
            cytoskeleton organization 1459
              actin cytoskeleton organization 747
                actin filament organization 466
                  actin polymerization or depolymerization 235
                    regulation of actin polymerization or depolymerization 202
                      regulation of actin filament depolymerization 62
                        negative regulation of actin filament depolymerization 52
                          actin filament capping 46
                            barbed-end actin filament capping + 29
                            pointed-end actin filament capping 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.