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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of protein kinase B signaling
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Accession:GO:0051896 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
Synonyms:related_synonym: regulation of AKT signaling cascade;   regulation of AKT signalling cascade;   regulation of PKB signaling cascade;   regulation of PKB signalling cascade;   regulation of protein kinase B signaling cascade;   regulation of protein kinase B signalling cascade


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regulation of protein kinase B signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291
G Gata4 GATA binding protein 4 JBrowse link 15 46,386,703 46,458,679 RGD:1624291
G Grm2 glutamate metabotropic receptor 2 JBrowse link 8 115,344,999 115,358,628 RGD:21201273
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:1624291
G Inpp4b inositol polyphosphate-4-phosphatase type II B JBrowse link 19 29,592,889 30,341,528 RGD:1624291
G Inpp5f inositol polyphosphate-5-phosphatase F JBrowse link 1 200,037,749 200,116,524 RGD:8554422
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1624291
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:13792537
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:1600115
RGD:13792537
RGD:1624291
G Ntrk3 neurotrophic receptor tyrosine kinase 3 JBrowse link 1 139,890,537 140,262,503 RGD:13792537
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:13792537
G Rcn3 reticulocalbin 3 JBrowse link 1 101,076,971 101,086,198 RGD:1600115
RGD:1624291
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 2 56,013,898 56,105,818 RGD:1624291
G Rnf41 ring finger protein 41 JBrowse link 7 2,827,242 2,854,230 RGD:1624291
G Rras RAS related JBrowse link 1 101,012,822 101,016,720 RGD:1624291
G Sesn1 sestrin 1 JBrowse link 20 46,667,116 46,758,306 RGD:1624291
G Sesn3 sestrin 3 JBrowse link 8 12,823,060 12,878,749 RGD:1624291
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1624291
RGD:1600115
G Tpte2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 JBrowse link 16 74,552,859 74,662,194 RGD:13792537
negative regulation of protein kinase B signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bank1 B-cell scaffold protein with ankyrin repeats 1 JBrowse link 2 241,273,763 241,545,527 RGD:1624291
RGD:13792537
G Btn2a2 butyrophilin, subfamily 2, member A2 JBrowse link 17 43,867,243 43,878,734 RGD:1624291
G Cavin3 caveolae associated protein 3 JBrowse link 1 170,317,099 170,318,688 RGD:1624291
G Cib1 calcium and integrin binding 1 JBrowse link 1 142,014,962 142,020,461 RGD:1624291
RGD:1600115
G Cryba1 crystallin, beta A1 JBrowse link 10 65,160,777 65,167,504 RGD:10059647
G Dag1 dystroglycan 1 JBrowse link 8 116,980,501 116,993,182 RGD:1624291
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:1624291
RGD:1600115
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:1624291
RGD:1600115
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1624291
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:1624291
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:1624291
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1624291
RGD:1600115
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:1624291
RGD:1600115
G Hyal2 hyaluronidase 2 JBrowse link 8 116,324,062 116,328,978 RGD:1600115
RGD:1624291
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:1624291
G Inpp5f inositol polyphosphate-5-phosphatase F JBrowse link 1 200,037,749 200,116,524 RGD:11059577
G Inpp5k inositol polyphosphate-5-phosphatase K JBrowse link 10 63,775,639 63,796,879 RGD:1624291
RGD:13792537
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:8553301
G Lemd2 LEM domain nuclear envelope protein 2 JBrowse link 20 5,779,742 5,786,213 RGD:1624291
G Lmbrd1 LMBR1 domain containing 1 JBrowse link 9 30,939,555 31,038,381 RGD:1624291
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 JBrowse link 4 10,995,241 12,472,423 RGD:1600115
RGD:1624291
G Mir143 microRNA 143 JBrowse link 18 56,971,273 56,971,377 RGD:1624291
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:1624291
G Mstn myostatin JBrowse link 9 53,310,977 53,315,804 RGD:1624291
G Mtm1 myotubularin 1 JBrowse link 6 18,821,821 18,840,449 RGD:1624291
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 5 156,855,105 156,864,517 RGD:1624291
G Nop53 NOP53 ribosome biogenesis factor JBrowse link 1 77,836,522 77,843,991 RGD:1624291
G Otud3 OTU deubiquitinase 3 JBrowse link 5 157,346,286 157,368,450 RGD:1624291
G Pdcd6 programmed cell death 6 JBrowse link 1 31,576,183 31,591,852 RGD:1624291
G Phlda3 pleckstrin homology-like domain, family A, member 3 JBrowse link 13 52,588,917 52,592,002 RGD:1624291
RGD:13792537
RGD:1600115
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 JBrowse link 13 26,145,989 26,394,505 RGD:8693633
RGD:1624291
RGD:1600115
G Pkhd1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin JBrowse link 9 26,164,969 26,736,704 RGD:1624291
G Plekha1 pleckstrin homology domain containing A1 JBrowse link 1 201,429,716 201,481,411 RGD:1624291
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:1624291
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:1624291
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:1624291
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
RGD:1600115
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Slc9a3r1 SLC9A3 regulator 1 JBrowse link 10 103,713,045 103,730,145 RGD:1624291
RGD:1600115
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1624291
RGD:13792537
G Tsc2_v1 TSC complex subunit 2, variant 1 RGD:13792537
G Tsc2_v2 TSC complex subunit 2, variant 2 RGD:13792537
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:1600115
RGD:1624291
positive regulation of protein kinase B signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam8 ADAM metallopeptidase domain 8 JBrowse link 1 212,317,510 212,332,895 RGD:1624291
G Akr1c2 aldo-keto reductase family 1, member C2 JBrowse link 17 69,388,337 69,435,160 RGD:1624291
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:1624291
G Angpt1 angiopoietin 1 JBrowse link 7 81,338,327 81,592,459 RGD:1600115
RGD:1624291
G Arfgef1 ADP ribosylation factor guanine nucleotide exchange factor 1 JBrowse link 5 8,666,046 8,760,458 RGD:10047159
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5510006
RGD:1624291
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:1624291
RGD:13792537
G Bag4 BAG cochaperone 4 JBrowse link 16 71,057,709 71,075,874 RGD:1624291
RGD:1600115
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G C1qtnf1 C1q and TNF related 1 JBrowse link 10 107,455,845 107,477,160 RGD:1624291
G C1qtnf12 C1q and TNF related 12 JBrowse link 5 173,390,901 173,395,276 RGD:1624291
G C1qtnf3 C1q and TNF related 3 JBrowse link 2 60,920,160 60,942,586 RGD:1624291
G Calcr calcitonin receptor JBrowse link 4 28,627,439 28,702,559 RGD:1624291
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:1624291
G Ccl21 C-C motif chemokine ligand 21 JBrowse link 5 58,197,678 58,198,782 RGD:1624291
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:1624291
G Cd28 Cd28 molecule JBrowse link 9 67,546,408 67,573,858 RGD:1624291
RGD:1600115
G Chi3l1 chitinase 3 like 1 JBrowse link 13 51,022,844 51,030,797 RGD:1624291
RGD:1600115
G Cpne1 copine 1 JBrowse link 3
3
151,617,733
152,150,143
151,625,448
152,192,936
RGD:1624291
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:1624291
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:1600115
RGD:1624291
RGD:13673777
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:4892026
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:1624291
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:1624291
RGD:1600115
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:1624291
RGD:1600115
G F7 coagulation factor VII JBrowse link 16 81,824,610 81,834,923 RGD:1624291
G Fam110c family with sequence similarity 110, member C JBrowse link 6 49,968,473 49,974,730 RGD:1624291
RGD:1600115
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:1624291
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:1624291
G Fpr2 formyl peptide receptor 2 JBrowse link 1 59,800,558 59,809,507 RGD:14695080
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:8554638
RGD:1624291
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:1624291
RGD:1600115
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) JBrowse link 17 21,634,546 21,677,477 RGD:1624291
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:1600115
RGD:1624291
G Gfral GDNF family receptor alpha like JBrowse link 8 83,235,647 83,282,635 RGD:1624291
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:1624291
RGD:1600115
G Hax1 HCLS1 associated protein X-1 JBrowse link 2 189,330,900 189,333,305 RGD:1624291
RGD:1600115
G Hbegf heparin-binding EGF-like growth factor JBrowse link 18 29,330,302 29,340,185 RGD:1624291
G Hcls1 hematopoietic cell specific Lyn substrate 1 JBrowse link 11 66,736,966 66,759,402 RGD:1624291
G Hpse heparanase JBrowse link 14 10,534,358 10,576,686 RGD:1600115
RGD:1624291
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:1624291
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:1624291
G Iapp islet amyloid polypeptide JBrowse link 4 176,509,863 176,517,903 RGD:1624291
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:1624291
RGD:13792537
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:1624291
RGD:1600115
G Igfbp5 insulin-like growth factor binding protein 5 JBrowse link 9 80,154,230 80,166,813 RGD:1624291
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:1600115
RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:5128677
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:2302063
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1624291
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:1624291
RGD:13792537
RGD:1600115
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1624291
RGD:1600115
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,633 RGD:1624291
G Itsn1 intersectin 1 JBrowse link 11 31,943,119 32,069,249 RGD:1624291
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:1624291
RGD:1600115
G Lin28a lin-28 homolog A JBrowse link 5 152,230,343 152,247,873 RGD:1624291
G LOC103694380 tumor necrosis factor-like JBrowse link 20 4,855,792 4,858,447 RGD:13673777
G LOC259246 alpha-2u globulin PGCL1 RGD:1600115
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:1600115
RGD:1624291
G Maz MYC associated zinc finger protein JBrowse link 1 198,456,699 198,460,126 RGD:1624291
G Mc1r melanocortin 1 receptor JBrowse link 19 56,215,420 56,219,987 RGD:1624291
G Meis3 Meis homeobox 3 JBrowse link 1 78,065,617 78,079,698 RGD:1624291
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:13792537
G Mfhas1 malignant fibrous histiocytoma amplified sequence 1 JBrowse link 16 60,120,457 60,208,550 RGD:1624291
G Mir205 microRNA 205 JBrowse link 13 112,233,283 112,233,390 RGD:1624291
G Mir494 microRNA 494 JBrowse link 6 133,864,370 133,864,452 RGD:1624291
G Mst1r macrophage stimulating 1 receptor JBrowse link 8 116,686,601 116,700,132 RGD:1624291
RGD:13792537
G Mtdh metadherin JBrowse link 7 72,771,018 72,830,599 RGD:1624291
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:2307383
G Mydgf myeloid-derived growth factor JBrowse link 9 10,885,521 10,892,744 RGD:1624291
G Myoc myocilin JBrowse link 13 80,517,531 80,527,928 RGD:1600115
RGD:1624291
G Myorg myogenesis regulating glycosidase JBrowse link 5 57,873,404 57,882,008 RGD:1624291
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:5508731
G Nox4 NADPH oxidase 4 JBrowse link 1 150,796,359 150,976,186 RGD:1624291
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:1624291
RGD:1600115
G Nrxn1 neurexin 1 JBrowse link 6 13,886,757 15,191,660 RGD:1624291
G Osbpl8 oxysterol binding protein-like 8 JBrowse link 7 53,878,906 54,030,110 RGD:1624291
G Osm oncostatin M JBrowse link 14 84,457,487 84,469,426 RGD:1624291
G P2rx4 purinergic receptor P2X 4 JBrowse link 12 39,308,022 39,325,673 RGD:13673751
G P2ry12 purinergic receptor P2Y12 JBrowse link 2 149,440,807 149,482,592 RGD:13673751
RGD:13673786
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:1600115
RGD:1624291
G Phb prohibitin JBrowse link 10 83,476,107 83,488,878 RGD:30309944
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 JBrowse link 13 26,145,989 26,394,505 RGD:8693633
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma JBrowse link 6 51,465,696 51,501,234 RGD:1624291
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:1624291
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:1600115
RGD:1624291
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
G Ramp3 receptor activity modifying protein 3 JBrowse link 14 86,922,223 86,939,722 RGD:1624291
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:8553301
G Rasd2 RASD family, member 2 JBrowse link 19 14,653,198 14,663,914 RGD:1304287
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:1600115
RGD:1624291
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 2 56,013,898 56,105,818 RGD:2307383
RGD:13792537
G Rtn4 reticulon 4 JBrowse link 14 114,126,931 114,174,459 RGD:1600115
RGD:1624291
G Sema5a semaphorin 5A JBrowse link 2 85,377,318 85,808,970 RGD:1624291
RGD:1600115
G Specc1l sperm antigen with calponin homology and coiled-coil domains 1-like JBrowse link 20 14,287,470 14,393,879 RGD:1624291
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:1624291
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1624291
G Stk3 serine/threonine kinase 3 JBrowse link 7 73,617,926 73,883,896 RGD:1624291
RGD:1600115
G Stox1 storkhead box 1 JBrowse link 20 32,276,857 32,353,677 RGD:1624291
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:1624291
G Tek TEK receptor tyrosine kinase JBrowse link 5 113,725,717 113,852,799 RGD:1624291
RGD:13792537
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1624291
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
G Thpo thrombopoietin JBrowse link 11 82,845,676 82,853,439 RGD:1624291
RGD:1600115
G Thpol1 thrombopoietin like 1 JBrowse link 11 83,867,549 83,874,670 RGD:1600115
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
RGD:13673777
G Tnfaip8l3 TNF alpha induced protein 8 like 3 JBrowse link 8 58,599,382 58,648,045 RGD:1624291
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:1624291
G Tspyl5 TSPY-like 5 JBrowse link 7 72,323,764 72,328,228 RGD:1624291
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1624291
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    signaling 7531
      signal transduction 6946
        intracellular signal transduction 2594
          regulation of intracellular signal transduction 1694
            regulation of protein kinase B signaling 173
              negative regulation of protein kinase B signaling 46
              positive regulation of protein kinase B signaling 116
Path 2
Term Annotations click to browse term
  biological_process 19678
    biological regulation 13599
      regulation of biological process 12921
        regulation of cellular process 12405
          signal transduction 6946
            regulation of signal transduction 2971
              regulation of intracellular signal transduction 1694
                regulation of protein kinase B signaling 173
                  negative regulation of protein kinase B signaling 46
                  positive regulation of protein kinase B signaling 116
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.