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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of protein kinase B signaling
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Accession:GO:0051898 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
Synonyms:exact_synonym: negative regulation of AKT signalling cascade;   negative regulation of PKB signaling cascade
 narrow_synonym: inhibition of protein kinase B signaling cascade
 related_synonym: down regulation of protein kinase B signaling cascade;   downregulation of protein kinase B signaling cascade;   negative regulation of AKT signaling cascade;   negative regulation of PKB signalling cascade;   negative regulation of protein kinase B signaling cascade;   negative regulation of protein kinase B signalling cascade


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negative regulation of protein kinase B signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bank1 B-cell scaffold protein with ankyrin repeats 1 JBrowse link 2 241,273,763 241,545,527 RGD:1624291
RGD:13792537
G Btn2a2 butyrophilin, subfamily 2, member A2 JBrowse link 17 43,867,243 43,878,734 RGD:1624291
G Cavin3 caveolae associated protein 3 JBrowse link 1 170,317,099 170,318,688 RGD:1624291
G Cib1 calcium and integrin binding 1 JBrowse link 1 142,014,962 142,020,461 RGD:1624291
RGD:1600115
G Cryba1 crystallin, beta A1 JBrowse link 10 65,160,777 65,167,504 RGD:10059647
G Dag1 dystroglycan 1 JBrowse link 8 116,980,501 116,993,182 RGD:1624291
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:1624291
RGD:1600115
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:1624291
RGD:1600115
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1624291
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:1624291
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:1624291
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1624291
RGD:1600115
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:1624291
RGD:1600115
G Hyal2 hyaluronidase 2 JBrowse link 8 116,324,062 116,328,978 RGD:1600115
RGD:1624291
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:1624291
G Inpp5f inositol polyphosphate-5-phosphatase F JBrowse link 1 200,037,749 200,116,524 RGD:11059577
G Inpp5k inositol polyphosphate-5-phosphatase K JBrowse link 10 63,775,639 63,796,879 RGD:1624291
RGD:13792537
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:8553301
G Lemd2 LEM domain nuclear envelope protein 2 JBrowse link 20 5,779,742 5,786,213 RGD:1624291
G Lmbrd1 LMBR1 domain containing 1 JBrowse link 9 30,939,555 31,038,381 RGD:1624291
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 JBrowse link 4 10,995,241 12,472,423 RGD:1600115
RGD:1624291
G Mir143 microRNA 143 JBrowse link 18 56,971,273 56,971,377 RGD:1624291
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:1624291
G Mstn myostatin JBrowse link 9 53,310,977 53,315,804 RGD:1624291
G Mtm1 myotubularin 1 JBrowse link 6 18,821,821 18,840,449 RGD:1624291
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 5 156,855,105 156,864,517 RGD:1624291
G Nop53 NOP53 ribosome biogenesis factor JBrowse link 1 77,836,522 77,843,991 RGD:1624291
G Otud3 OTU deubiquitinase 3 JBrowse link 5 157,346,286 157,368,450 RGD:1624291
G Pdcd6 programmed cell death 6 JBrowse link 1 31,576,183 31,591,852 RGD:1624291
G Phlda3 pleckstrin homology-like domain, family A, member 3 JBrowse link 13 52,588,917 52,592,002 RGD:1624291
RGD:13792537
RGD:1600115
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 JBrowse link 13 26,145,989 26,394,505 RGD:8693633
RGD:1624291
RGD:1600115
G Pkhd1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin JBrowse link 9 26,164,969 26,736,704 RGD:1624291
G Plekha1 pleckstrin homology domain containing A1 JBrowse link 1 201,429,716 201,481,411 RGD:1624291
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:1624291
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:1624291
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:1624291
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
RGD:1600115
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Slc9a3r1 SLC9A3 regulator 1 JBrowse link 10 103,713,045 103,730,145 RGD:1624291
RGD:1600115
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1624291
RGD:13792537
G Tsc2_v1 TSC complex subunit 2, variant 1 RGD:13792537
G Tsc2_v2 TSC complex subunit 2, variant 2 RGD:13792537
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    negative regulation of biological process 5617
      negative regulation of signaling 1396
        negative regulation of signal transduction 1232
          negative regulation of intracellular signal transduction 546
            negative regulation of protein kinase B signaling 46
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            intracellular signal transduction 2597
              protein kinase B signaling 205
                regulation of protein kinase B signaling 173
                  negative regulation of protein kinase B signaling 46
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.