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ONTOLOGY REPORT - ANNOTATIONS


Term:membrane depolarization
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Accession:GO:0051899 term browser browse the term
Definition:The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.


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membrane depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora2a adenosine A2a receptor JBrowse link 20 14,265,251 14,282,873 RGD:1625443
G Best2 bestrophin 2 JBrowse link 19 26,122,869 26,129,619 RGD:1624291
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:1600115
RGD:1624291
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 JBrowse link 7 119,228,112 119,353,332 RGD:1624291
RGD:1600115
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
RGD:1600115
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit JBrowse link 3 176,533,182 176,547,965 RGD:1600115
RGD:1624291
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit JBrowse link 16 68,860,018 68,866,718 RGD:1624291
RGD:1600115
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 2 189,088,570 189,096,785 RGD:1624291
RGD:1600115
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 JBrowse link 14 38,155,771 38,171,107 RGD:6902904
G Cnga2 cyclic nucleotide gated channel subunit alpha 2 JBrowse link 16 69,878,513 69,899,075 RGD:6902904
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:1580292
G Grik1 glutamate ionotropic receptor kainate type subunit 1 JBrowse link 11 27,811,954 28,213,940 RGD:1624291
G Grm1 glutamate metabotropic receptor 1 JBrowse link 1 4,753,141 5,165,859 RGD:728711
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:2290591
G Kmt2a lysine methyltransferase 2A JBrowse link 8 49,110,407 49,185,872 RGD:9588219
G P2rx4 purinergic receptor P2X 4 JBrowse link 12 39,308,022 39,325,673 RGD:1624291
RGD:1600115
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
RGD:1600115
RGD:69918
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642699
G Scn1b sodium voltage-gated channel beta subunit 1 JBrowse link 1 89,550,738 89,560,469 RGD:1624291
G Scn3b sodium voltage-gated channel beta subunit 3 JBrowse link 8 44,136,413 44,159,011 RGD:1624291
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1600115
RGD:1624291
G Snap91 synaptosome associated protein 91 JBrowse link 8 94,447,558 94,564,772 RGD:70605
membrane depolarization during action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:13792537
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:13792537
G Cacna1i calcium voltage-gated channel subunit alpha1 I JBrowse link 7 121,521,787 121,619,300 RGD:13792537
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:1624291
RGD:1600115
G Scn10a sodium voltage-gated channel alpha subunit 10 JBrowse link 8 128,298,593 128,416,896 RGD:13792537
G Scn11a sodium voltage-gated channel alpha subunit 11 JBrowse link 8 128,450,793 128,527,510 RGD:13792537
G Scn1a sodium voltage-gated channel alpha subunit 1 JBrowse link 3 52,388,811 52,533,365 RGD:13792537
G Scn2a sodium voltage-gated channel alpha subunit 2 JBrowse link 3 51,687,910 51,822,008 RGD:13792537
G Scn3a sodium voltage-gated channel alpha subunit 3 JBrowse link 3 51,530,897 51,643,140 RGD:13792537
G Scn3b sodium voltage-gated channel beta subunit 3 JBrowse link 8 44,136,413 44,159,011 RGD:1624291
G Scn4a sodium voltage-gated channel alpha subunit 4 JBrowse link 10 94,505,026 94,557,803 RGD:13792537
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1600115
RGD:13792537
RGD:1624291
G Scn7a sodium voltage-gated channel alpha subunit 7 JBrowse link 3 52,775,779 52,877,365 RGD:13792537
G Scn8a sodium voltage-gated channel alpha subunit 8 JBrowse link 7 142,575,629 142,683,659 RGD:13792537
G Scn9a sodium voltage-gated channel alpha subunit 9 JBrowse link 3 52,583,953 52,664,209 RGD:13792537
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta JBrowse link 14 83,053,041 83,062,424 RGD:1624291
RGD:1600115
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:1624291
RGD:1600115
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 17 81,673,862 82,019,219 RGD:1624291
RGD:1600115
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1624291
membrane depolarization during AV node cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:1624291
RGD:1600115
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:1624291
RGD:1600115
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 17 81,673,862 82,019,219 RGD:1624291
RGD:1600115
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1624291
RGD:1600115
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 JBrowse link 1 101,293,300 101,323,484 RGD:1600115
RGD:1624291
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 JBrowse link 4 15,706,974 16,130,848 RGD:1600115
RGD:1624291
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1624291
RGD:1600115
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 JBrowse link 1 101,293,300 101,323,484 RGD:1600115
RGD:1624291
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:1624291
RGD:1600115
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:6767284
G Scn1b sodium voltage-gated channel beta subunit 1 JBrowse link 1 89,550,738 89,560,469 RGD:1624291
G Scn2b sodium voltage-gated channel beta subunit 2 JBrowse link 8 49,419,003 49,431,110 RGD:1624291
RGD:1600115
G Scn3b sodium voltage-gated channel beta subunit 3 JBrowse link 8 44,136,413 44,159,011 RGD:1624291
RGD:1600115
G Scn4b sodium voltage-gated channel beta subunit 4 JBrowse link 8 49,441,106 49,456,279 RGD:1624291
RGD:1600115
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1624291
RGD:1600115
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Scn1b sodium voltage-gated channel beta subunit 1 JBrowse link 1 89,550,738 89,560,469 RGD:1624291
RGD:1600115
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1624291
RGD:1600115
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 JBrowse link 1 101,293,300 101,323,484 RGD:1600115
RGD:1624291
membrane depolarization during SA node cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:1624291
RGD:1600115
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:1624291
RGD:1600115
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 JBrowse link 8 63,599,907 63,637,327 RGD:1600115
RGD:1624291
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1624291
RGD:1600115
mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp5if1 ATP synthase inhibitory factor subunit 1 JBrowse link 5 150,719,570 150,723,287 RGD:1624291
RGD:1600115
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:1624291
RGD:1600115
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291
RGD:1600115
negative regulation of mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
RGD:1600115
G Got1 glutamic-oxaloacetic transaminase 1 JBrowse link 1 263,246,248 263,269,762 RGD:13504824
G Hsh2d hematopoietic SH2 domain containing JBrowse link 16 19,336,400 19,349,868 RGD:1624291
RGD:1600115
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:5508731
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1624291
RGD:1600115
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ank3 ankyrin 3 JBrowse link 20 19,948,767 20,480,628 RGD:6767295
positive regulation of mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:2313870
G Cck cholecystokinin JBrowse link 8 130,120,525 130,127,515 RGD:625521
G Dcn decorin JBrowse link 7 38,742,250 38,782,282 RGD:1624291
RGD:1600115
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:1624291
RGD:1600115
G Mllt11 MLLT11, transcription factor 7 cofactor JBrowse link 2 196,392,936 196,402,106 RGD:1624291
RGD:1600115
G Myoc myocilin JBrowse link 13 80,517,531 80,527,928 RGD:1600115
RGD:1624291
G Oga O-GlcNAcase JBrowse link 1 265,506,752 265,542,452 RGD:2305938
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:10413888
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:1624291
G Tspo translocator protein JBrowse link 7 124,460,358 124,470,610 RGD:2317155
positive regulation of regulation of vascular smooth muscle cell membrane depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 JBrowse link 1 101,293,300 101,323,484 RGD:10003037
regulation of atrial cardiac muscle cell membrane depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:1624291
RGD:1600115
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:1624291
RGD:1600115
G Gja5 gap junction protein, alpha 5 JBrowse link 2 199,162,745 199,184,942 RGD:1624291
RGD:1600115
G Scn10a sodium voltage-gated channel alpha subunit 10 JBrowse link 8 128,298,593 128,416,896 RGD:1624291
RGD:1600115
G Scn1b sodium voltage-gated channel beta subunit 1 JBrowse link 1 89,550,738 89,560,469 RGD:1624291
RGD:1600115
G Scn2b sodium voltage-gated channel beta subunit 2 JBrowse link 8 49,419,003 49,431,110 RGD:1624291
RGD:1600115
G Scn3b sodium voltage-gated channel beta subunit 3 JBrowse link 8 44,136,413 44,159,011 RGD:1624291
RGD:1600115
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1600115
RGD:13792537
RGD:1624291
regulation of membrane depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:1624291
G Camk2d calcium/calmodulin-dependent protein kinase II delta JBrowse link 2 230,900,907 231,132,207 RGD:1624291
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:1624291
G Fgf12 fibroblast growth factor 12 JBrowse link 11 75,606,360 76,171,078 RGD:6484231
G Fhl1 four and a half LIM domains 1 JBrowse link X 159,112,516 159,172,528 RGD:1624291
RGD:1600115
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 JBrowse link 2 50,099,576 50,499,799 RGD:9686372
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 JBrowse link 8 63,599,907 63,637,327 RGD:1624291
RGD:1600115
G Nedd4l NEDD4 like E3 ubiquitin protein ligase JBrowse link 18 60,392,376 60,719,720 RGD:1624291
RGD:1600115
G Npff neuropeptide FF-amide peptide precursor JBrowse link 7 144,127,084 144,127,873 RGD:2316567
G Ntsr1 neurotensin receptor 1 JBrowse link 3 175,982,313 176,046,345 RGD:9743930
G Rangrf RAN guanine nucleotide release factor JBrowse link 10 55,559,049 55,560,420 RGD:1624291
regulation of membrane depolarization during action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 JBrowse link 5 74,248,996 74,368,167 RGD:1624291
RGD:1600115
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291
RGD:13792537
G Gja5 gap junction protein, alpha 5 JBrowse link 2 199,162,745 199,184,942 RGD:1624291
RGD:1600115
G Rangrf RAN guanine nucleotide release factor JBrowse link 10 55,559,049 55,560,420 RGD:1624291
RGD:1600115
G Slmap sarcolemma associated protein JBrowse link 16 2,112,271 2,227,336 RGD:1624291
regulation of mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcd1 ATP binding cassette subfamily D member 1 JBrowse link X 157,073,860 157,095,652 RGD:1600115
RGD:1624291
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:1624291
RGD:1600115
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:1624291
RGD:1600115
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:1600115
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma JBrowse link 6 76,056,585 76,079,755 RGD:1624291
RGD:1600115
regulation of ventricular cardiac muscle cell membrane depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291
RGD:1600115
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:1624291
RGD:1600115
G Gja5 gap junction protein, alpha 5 JBrowse link 2 199,162,745 199,184,942 RGD:1624291
RGD:1600115
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like JBrowse link 8 122,957,570 122,987,236 RGD:1624291
RGD:1600115
G Scn3b sodium voltage-gated channel beta subunit 3 JBrowse link 8 44,136,413 44,159,011 RGD:1624291
RGD:1600115
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1600115
RGD:1624291

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Term Annotations click to browse term
  biological_process 18166
    biological regulation 12793
      regulation of biological quality 4168
        regulation of membrane potential 467
          membrane depolarization 85
            membrane depolarization during action potential + 31
            mitochondrial depolarization + 24
            negative regulation of membrane depolarization + 6
            positive regulation of membrane depolarization + 13
            regulation of membrane depolarization + 46
            regulation of vascular smooth muscle cell membrane depolarization + 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.