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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, GABAergic
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Accession:GO:0051932 term browser browse the term
Definition:The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms:exact_synonym: synaptic transmission, GABA mediated;   synaptic transmission, gamma-aminobutyric acid mediated;   synaptic transmission, gamma-aminobutyric acid-ergic


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synaptic transmission, GABAergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CACNA1A calcium voltage-gated channel subunit alpha1 A JBrowse link 2 65,491,784 65,871,068 RGD:9068941
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 JBrowse link 15 402,801 455,691 RGD:9068941
G CLCN3 chloride voltage-gated channel 3 JBrowse link 14 20,037,628 20,127,160 RGD:9068941
G CLSTN3 calsyntenin 3 JBrowse link 5 63,572,062 63,612,177 RGD:14298760
G DNM1 dynamin 1 JBrowse link 1 268,653,045 268,702,233 RGD:9068941
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 JBrowse link 16 61,656,583 61,723,428 RGD:14298760
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 JBrowse link 8 36,344,633 36,474,840 RGD:14298760
G GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 JBrowse link X 123,456,952 123,684,814 RGD:14298760
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 JBrowse link 8 36,875,649 36,943,016 RGD:14298760
G GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 JBrowse link 1 140,486,107 140,568,204 RGD:14298760
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 16 61,855,698 61,872,503 RGD:14298760
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 JBrowse link 16 61,984,923 62,240,902 RGD:9068941
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 JBrowse link 1 140,566,443 140,906,516 RGD:9068941
G GABRE gamma-aminobutyric acid type A receptor subunit epsilon JBrowse link X 123,278,459 123,296,070 RGD:14298760
G GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 JBrowse link 8 36,198,056 36,262,492 RGD:14298760
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 JBrowse link 16 61,441,622 61,543,375 RGD:14298760
G GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 JBrowse link 1 139,855,461 140,464,592 RGD:14298760
G RAC1 Rac family small GTPase 1 JBrowse link 3 4,781,776 4,803,510 RGD:9068941
G RAC3 Rac family small GTPase 3 JBrowse link 12 981,072 984,222 RGD:14298760
gamma-aminobutyric acid secretion, neurotransmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NF1 neurofibromin 1 JBrowse link 12 43,487,098 43,754,205 RGD:14298760
G PAK1 p21 (RAC1) activated kinase 1 JBrowse link 9 11,830,095 11,973,074 RGD:9068941
negative regulation of synaptic transmission, GABAergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADORA1 adenosine A1 receptor JBrowse link 9 113,835,279 113,875,899 RGD:9068941
G BDNF brain derived neurotrophic factor JBrowse link 2 32,623,668 32,679,293 RGD:14298760
G CNR2 cannabinoid receptor 2 JBrowse link 6 81,659,162 81,692,550 RGD:9068941
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 JBrowse link 13 192,877,707 193,296,954 RGD:9068941
G HTR1B 5-hydroxytryptamine receptor 1B JBrowse link 1 88,597,510 88,598,682 RGD:9068941
G NPY5R neuropeptide Y receptor Y5 JBrowse link 8 52,173,906 52,183,336 RGD:9068941
G SLC6A1 solute carrier family 6 member 1 JBrowse link 13 67,156,786 67,199,092 RGD:9068941
G STXBP1 syntaxin binding protein 1 JBrowse link 1 268,116,124 268,205,805 RGD:14298760
positive regulation of synaptic transmission, GABAergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADORA2A adenosine A2a receptor JBrowse link 14 49,467,186 49,485,845 RGD:14298760
G ADRA1A adrenoceptor alpha 1A JBrowse link 14 10,623,391 10,733,378 RGD:9068941
G CA2 carbonic anhydrase 2 JBrowse link 4 51,194,686 51,211,436 RGD:14298760
G CA7 carbonic anhydrase 7 JBrowse link 6 27,548,647 27,563,966 RGD:14298760
G CCKBR cholecystokinin B receptor JBrowse link 9 3,409,222 3,419,513 RGD:9068941
G ERBB4 erb-b2 receptor tyrosine kinase 4 JBrowse link 15 113,966,573 115,096,984 RGD:9068941
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 JBrowse link 13 192,877,707 193,296,954 RGD:9068941
G HAP1 huntingtin associated protein 1 JBrowse link 12 20,938,463 20,950,053 RGD:9068941
G KIF5B kinesin family member 5B JBrowse link 10 42,637,105 42,693,551 RGD:14298760
G NLGN1 neuroligin 1 JBrowse link 13 111,851,007 112,727,202 RGD:9068941
G NPS neuropeptide S JBrowse link 14 136,835,630 136,839,511 RGD:14298760
G OXTR oxytocin receptor JBrowse link 13 65,134,055 65,155,543 RGD:9068941
G PRKCE protein kinase C epsilon JBrowse link 3 94,351,277 94,864,549 RGD:14298760
G TAC1 tachykinin precursor 1 JBrowse link 9 77,197,403 77,206,529 RGD:9068941
G TACR1 tachykinin receptor 1 JBrowse link 3 67,839,367 68,021,733 RGD:9068941
G ZDHHC3 zinc finger DHHC-type palmitoyltransferase 3 JBrowse link 13 28,100,529 28,176,733 RGD:14298760
regulation of synaptic transmission, GABAergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BAIAP3 BAI1 associated protein 3 JBrowse link 3 40,536,557 40,550,508 RGD:9068941
G CLN3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 3 18,433,564 18,450,296 RGD:14298760
G CNR1 cannabinoid receptor 1 JBrowse link 1 56,466,022 56,493,275 RGD:9068941
G CNTNAP4 contactin associated protein family member 4 JBrowse link 6 11,316,534 11,589,628 RGD:14298760
G DBI diazepam binding inhibitor, acyl-CoA binding protein JBrowse link 15 24,895,575 24,900,710 RGD:9068941
G DRD2 dopamine receptor D2 JBrowse link 9 41,068,618 41,135,262 RGD:14298760
G KRAS KRAS proto-oncogene, GTPase JBrowse link 5 48,508,774 48,546,260 RGD:14298760
G NF1 neurofibromin 1 JBrowse link 12 43,487,098 43,754,205 RGD:14298760
G NISCH nischarin JBrowse link 13 34,595,788 34,630,306 RGD:9068941
G NPAS4 neuronal PAS domain protein 4 JBrowse link 2 5,990,936 5,995,940 RGD:14298760
G PHF24 PHD finger protein 24 JBrowse link 1 235,757,499 235,783,053 RGD:14298760
G PLCL1 phospholipase C like 1 JBrowse link 15 101,602,336 102,424,225 RGD:14298760
G PLCL2 phospholipase C like 2 JBrowse link 13 3,992,230 4,201,574 RGD:14298760
G PTEN phosphatase and tensin homolog JBrowse link 14 99,929,590 100,021,619 RGD:9068941
G USP46 ubiquitin specific peptidase 46 JBrowse link 8 39,518,155 39,581,990 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16411
    signaling 6414
      cell-cell signaling 1681
        synaptic signaling 843
          trans-synaptic signaling 815
            anterograde trans-synaptic signaling 807
              chemical synaptic transmission 807
                synaptic transmission, GABAergic 58
                  gamma-aminobutyric acid secretion, neurotransmission 2
                  negative regulation of synaptic transmission, GABAergic 8
                  positive regulation of synaptic transmission, GABAergic 16
                  regulation of synaptic transmission, GABAergic + 38
Path 2
Term Annotations click to browse term
  biological_process 16411
    cellular process 15624
      cell communication 6485
        cell-cell signaling 1681
          synaptic signaling 843
            trans-synaptic signaling 815
              anterograde trans-synaptic signaling 807
                chemical synaptic transmission 807
                  synaptic transmission, GABAergic 58
                    gamma-aminobutyric acid secretion, neurotransmission 2
                    negative regulation of synaptic transmission, GABAergic 8
                    positive regulation of synaptic transmission, GABAergic 16
                    regulation of synaptic transmission, GABAergic + 38
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.