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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac muscle cell differentiation
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Accession:GO:0055007 term browser browse the term
Definition:The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
Synonyms:exact_synonym: cardiomyocyte differentiation
 related_synonym: heart muscle cell differentiation


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cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACADM acyl-CoA dehydrogenase medium chain JBrowse link 1 76,911,763 76,950,840 RGD:9068941
G AKAP13 A-kinase anchoring protein 13 JBrowse link 15 83,289,867 83,651,362 RGD:9068941
G BMP2 bone morphogenetic protein 2 JBrowse link 20 6,546,173 6,558,627 RGD:9068941
G BMP4 bone morphogenetic protein 4 JBrowse link 14 52,821,872 52,828,781 RGD:9068941
G CACYBP calcyclin binding protein JBrowse link 1 154,209,195 154,220,583 RGD:9068941
G CALR calreticulin JBrowse link 19 13,242,900 13,249,416 RGD:9068941
G CBY1 chibby family member 1, beta catenin antagonist JBrowse link 22 37,389,924 37,406,879 RGD:9068941
G GATA6 GATA binding protein 6 JBrowse link 18 19,046,132 19,078,398 RGD:9068941
G IFT20 intraflagellar transport 20 JBrowse link 17 28,941,303 28,948,129 RGD:9068941
G ITGB1 integrin subunit beta 1 JBrowse link 10 33,608,978 33,662,258 RGD:9068941
G KDM6B lysine demethylase 6B JBrowse link 17 7,858,734 7,876,220 RGD:9068941
G MESP1 mesoderm posterior bHLH transcription factor 1 JBrowse link 15 87,645,768 87,647,210 RGD:9068941
G MYOCD myocardin JBrowse link 17 43,578,967 43,681,659 RGD:9068941
G NKX2-5 NK2 homeobox 5 JBrowse link 5 175,492,288 175,495,514 RGD:9068941
G NOX4 NADPH oxidase 4 JBrowse link 11 87,911,335 88,171,535 RGD:9068941
G NRG1 neuregulin 1 JBrowse link 8 29,049,787 29,267,531 RGD:9068941
G SIK1 salt inducible kinase 1 JBrowse link 21 42,975,914 42,987,948 RGD:9068941
G SLC9A1 solute carrier family 9 member A1 JBrowse link 1 27,414,937 27,475,089 RGD:9068941
G SOX6 SRY-box transcription factor 6 JBrowse link 11 15,747,495 16,175,439 RGD:9068941
G TBX5 T-box transcription factor 5 JBrowse link 12 115,336,267 115,389,739 RGD:9068941
G TSC1 TSC complex subunit 1 JBrowse link 9 132,638,003 132,692,264 RGD:9068941
atrial cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FHL2 four and a half LIM domains 2 JBrowse link 2A 106,446,368 106,524,555 RGD:9068941
G NKX2-5 NK2 homeobox 5 JBrowse link 5 175,492,288 175,495,514 RGD:9068941
G NKX2-6 NK2 homeobox 6 JBrowse link 8 19,884,480 19,888,643 RGD:9068941
atrioventricular bundle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TBX3 T-box transcription factor 3 JBrowse link 12 115,618,420 115,632,327 RGD:9068941
atrioventricular node cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MAML1 mastermind like transcriptional coactivator 1 JBrowse link 5 182,203,371 182,242,296 RGD:9068941
G NKX2-5 NK2 homeobox 5 JBrowse link 5 175,492,288 175,495,514 RGD:9068941
atrioventricular node cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NKX2-5 NK2 homeobox 5 JBrowse link 5 175,492,288 175,495,514 RGD:9068941
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G WNT3A Wnt family member 3A JBrowse link 1 208,628,706 208,674,469 RGD:9068941
G WNT8A Wnt family member 8A JBrowse link 5 139,598,229 139,605,926 RGD:9068941
cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTN2 actinin alpha 2 JBrowse link 1 217,276,899 217,321,103 RGD:9068941
G ALPK2 alpha kinase 2 JBrowse link 18 55,205,337 55,352,100 RGD:9068941
G ALPK3 alpha kinase 3 JBrowse link 15 82,808,402 82,864,291 RGD:9068941
G CAV3 caveolin 3 JBrowse link 3 8,928,069 8,940,942 RGD:9068941
G HNRNPU heterogeneous nuclear ribonucleoprotein U JBrowse link 1 225,830,663 225,842,031 RGD:9068941
G LRRC10 leucine rich repeat containing 10 JBrowse link 12 69,905,608 69,908,200 RGD:9068941
G MTOR mechanistic target of rapamycin kinase JBrowse link 1 11,093,765 11,249,841 RGD:9068941
G SGCB sarcoglycan beta JBrowse link 4 78,481,591 78,494,417 RGD:9068941
G SLC8A1 solute carrier family 8 member A1 JBrowse link 2A 40,936,799 41,444,963 RGD:9068941
cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACVR1 activin A receptor type 1 JBrowse link 2B 162,234,823 162,372,533 RGD:9068941
G TBX3 T-box transcription factor 3 JBrowse link 12 115,618,420 115,632,327 RGD:9068941
G WT1 WT1 transcription factor JBrowse link 11 32,238,720 32,282,879 RGD:9068941
cardiac muscle fiber development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CXADR CXADR Ig-like cell adhesion molecule JBrowse link 21 17,637,510 17,693,324 RGD:9068941
G MYH11 myosin heavy chain 11 JBrowse link 16 16,006,840 16,091,058 RGD:9068941
G MYH6 myosin heavy chain 6 JBrowse link 14 22,294,965 22,321,331 RGD:9068941
G MYO18B myosin XVIIIB JBrowse link 22 24,529,348 24,816,779 RGD:9068941
G MYOM1 myomesin 1 JBrowse link 18 13,368,052 13,523,834 RGD:9068941
G MYOM2 myomesin 2 JBrowse link 8 1,924,662 2,054,706 RGD:9068941
G MYOM3 myomesin 3 JBrowse link 1 24,237,338 24,293,396 RGD:9068941
G SGCD sarcoglycan delta JBrowse link 5 157,119,158 158,148,016 RGD:9068941
G TCAP titin-cap JBrowse link 17 17,839,139 17,841,500 RGD:9068941
G TTN titin JBrowse link 2B 183,487,352 183,767,268 RGD:9068941
G VEGFA vascular endothelial growth factor A JBrowse link 6 44,651,855 44,666,353 RGD:9068941
G ZMPSTE24 zinc metallopeptidase STE24 JBrowse link 1 40,869,076 40,912,747 RGD:9068941
cardiac muscle thin filament assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NEB nebulin JBrowse link 2B 156,060,919 156,275,265 RGD:9068941
G NEBL nebulette JBrowse link 10 21,238,946 21,632,236 RGD:9068941
G NRAP nebulin related anchoring protein JBrowse link 10 113,616,060 113,691,114 RGD:9068941
cardiac myofibril assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTC1 actin alpha cardiac muscle 1 JBrowse link 15 31,966,278 31,971,782 RGD:9068941
G CSRP3 cysteine and glycine rich protein 3 JBrowse link 11 19,121,234 19,149,374 RGD:9068941
G FHOD3 formin homology 2 domain containing 3 JBrowse link 18 33,163,910 33,590,683 RGD:9068941
G MYH10 myosin heavy chain 10 JBrowse link 17 47,756,244 47,912,747 RGD:9068941
G MYL2 myosin light chain 2 JBrowse link 12 111,873,270 111,883,047 RGD:9068941
G MYLK3 myosin light chain kinase 3 JBrowse link 16 45,858,723 45,919,859 RGD:9068941
G MYOM1 myomesin 1 JBrowse link 18 13,368,052 13,523,834 RGD:9068941
G MYOM2 myomesin 2 JBrowse link 8 1,924,662 2,054,706 RGD:9068941
G MYOM3 myomesin 3 JBrowse link 1 24,237,338 24,293,396 RGD:9068941
G OBSL1 obscurin like cytoskeletal adaptor 1 JBrowse link 2B 225,402,614 225,419,008 RGD:9068941
G PDGFRA platelet derived growth factor receptor alpha JBrowse link 4 76,200,871 76,271,105 RGD:9068941
G PDGFRB platelet derived growth factor receptor beta JBrowse link 5 151,543,581 151,585,630 RGD:9068941
G SRF serum response factor JBrowse link 6 44,057,192 44,066,768 RGD:9068941
G TCAP titin-cap JBrowse link 17 17,839,139 17,841,500 RGD:9068941
G TTN titin JBrowse link 2B 183,487,352 183,767,268 RGD:9068941
cell growth involved in cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADRA1A adrenoceptor alpha 1A JBrowse link 8 22,930,296 23,043,595 RGD:9068941
G AGT angiotensinogen JBrowse link 1 211,279,015 211,291,044 RGD:9068941
G AGTR2 angiotensin II receptor type 2 JBrowse link X 115,670,022 115,674,287 RGD:9068941
G AKAP13 A-kinase anchoring protein 13 JBrowse link 15 83,289,867 83,651,362 RGD:9068941
G GATA4 GATA binding protein 4 RGD:9068941
G MAP2K4 mitogen-activated protein kinase kinase 4 JBrowse link 17 44,246,301 44,359,906 RGD:9068941
G NPPA natriuretic peptide A JBrowse link 1 11,825,072 11,827,452 RGD:9068941
G PDLIM5 PDZ and LIM domain 5 JBrowse link 4 97,486,566 97,702,060 RGD:9068941
G SORBS2 sorbin and SH3 domain containing 2 JBrowse link 4 189,965,729 190,335,930 RGD:9068941
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DKK1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 10 51,084,963 51,088,424 RGD:9068941
negative regulation of cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BMP2 bone morphogenetic protein 2 JBrowse link 20 6,546,173 6,558,627 RGD:9068941
G DKK1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 10 51,084,963 51,088,424 RGD:9068941
G DLL1 delta like canonical Notch ligand 1 JBrowse link 6 173,535,941 173,545,362 RGD:9068941
G FRS2 fibroblast growth factor receptor substrate 2 JBrowse link 12 69,767,526 69,878,293 RGD:9068941
G FZD7 frizzled class receptor 7 JBrowse link 2B 207,444,640 207,448,359 RGD:9068941
G SOX6 SRY-box transcription factor 6 JBrowse link 11 15,747,495 16,175,439 RGD:9068941
negative regulation of cardiac myofibril assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SMAD4 SMAD family member 4 JBrowse link 18 47,692,311 47,802,530 RGD:9068941
negative regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CAV3 caveolin 3 JBrowse link 3 8,928,069 8,940,942 RGD:9068941
G CTDP1 CTD phosphatase subunit 1 JBrowse link 18 76,646,641 76,720,928 RGD:9068941
G G6PD glucose-6-phosphate dehydrogenase JBrowse link X 153,843,092 153,860,675 RGD:9068941
G GSK3A glycogen synthase kinase 3 alpha JBrowse link 19 47,710,197 47,722,531 RGD:9068941
G PAK1 p21 (RAC1) activated kinase 1 JBrowse link 11 76,014,744 76,166,503 RGD:9068941
G PI16 peptidase inhibitor 16 JBrowse link 6 37,711,423 37,721,812 RGD:9068941
G PPARA peroxisome proliferator activated receptor alpha JBrowse link 22 45,218,364 45,302,970 RGD:9068941
G RGS2 regulator of G protein signaling 2 JBrowse link 1 172,566,701 172,569,955 RGD:9068941
G RGS4 regulator of G protein signaling 4 JBrowse link 1 142,284,040 142,292,225 RGD:9068941
G YY1 YY1 transcription factor JBrowse link 14 100,173,287 100,217,651 RGD:9068941
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RBPJ recombination signal binding protein for immunoglobulin kappa J region JBrowse link 4 25,996,223 26,107,683 RGD:9068941
positive regulation of cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARRB2 arrestin beta 2 JBrowse link 17 4,757,048 4,767,517 RGD:9068941
G EFNB2 ephrin B2 JBrowse link 13 106,770,296 106,815,542 RGD:9068941
G GREM1 gremlin 1, DAN family BMP antagonist JBrowse link 15 30,051,483 30,068,243 RGD:9068941
G KAT2A lysine acetyltransferase 2A JBrowse link 17 15,416,075 15,424,197 RGD:9068941
G MEF2C myocyte enhancer factor 2C JBrowse link 5 26,620,837 26,786,426 RGD:9068941
G MYOCD myocardin JBrowse link 17 43,578,967 43,681,659 RGD:9068941
G NRG1 neuregulin 1 JBrowse link 8 29,049,787 29,267,531 RGD:9068941
G TGFB1 transforming growth factor beta 1 JBrowse link 19 46,831,659 46,852,973 RGD:9068941
G WNT3A Wnt family member 3A JBrowse link 1 208,628,706 208,674,469 RGD:9068941
positive regulation of cardiac muscle fiber development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BMP4 bone morphogenetic protein 4 JBrowse link 14 52,821,872 52,828,781 RGD:9068941
positive regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKAP6 A-kinase anchoring protein 6 JBrowse link 14 31,290,939 31,792,166 RGD:9068941
G DDX39B DExD-box helicase 39B JBrowse link 6 32,081,210 32,093,135 RGD:9068941
G EDN1 endothelin 1 JBrowse link 6 12,405,538 12,503,545 RGD:9068941
G HAMP hepcidin antimicrobial peptide JBrowse link 19 40,964,445 40,968,861 RGD:9068941
G IGF1 insulin like growth factor 1 JBrowse link 12 103,385,911 103,463,264 RGD:9068941
G MTOR mechanistic target of rapamycin kinase JBrowse link 1 11,093,765 11,249,841 RGD:9068941
G PARP2 poly(ADP-ribose) polymerase 2 JBrowse link 14 19,268,986 19,282,960 RGD:9068941
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 19 10,053,733 10,067,343 RGD:9068941
Purkinje myocyte differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NKX2-5 NK2 homeobox 5 JBrowse link 5 175,492,288 175,495,514 RGD:9068941
sinoatrial node cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BVES blood vessel epicardial substance JBrowse link 6 106,784,465 106,822,050 RGD:9068941
G TBX3 T-box transcription factor 3 JBrowse link 12 115,618,420 115,632,327 RGD:9068941
sinoatrial node cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MESP1 mesoderm posterior bHLH transcription factor 1 JBrowse link 15 87,645,768 87,647,210 RGD:9068941
ventricular cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATG5 autophagy related 5 JBrowse link 6 107,871,201 108,027,064 RGD:9068941
G BMP10 bone morphogenetic protein 10 JBrowse link 2A 70,023,781 70,034,383 RGD:9068941
G CCNB1 cyclin B1 JBrowse link 5 46,394,362 46,405,332 RGD:9068941
G CDK1 cyclin dependent kinase 1 JBrowse link 10 59,647,993 59,664,434 RGD:9068941
G FHL2 four and a half LIM domains 2 JBrowse link 2A 106,446,368 106,524,555 RGD:9068941
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 JBrowse link 6 127,647,547 127,659,056 RGD:9068941
G LMNA lamin A/C JBrowse link 1 135,253,700 135,311,542 RGD:9068941
G MYH10 myosin heavy chain 10 JBrowse link 17 47,756,244 47,912,747 RGD:9068941
G NKX2-5 NK2 homeobox 5 JBrowse link 5 175,492,288 175,495,514 RGD:9068941
G NKX2-6 NK2 homeobox 6 JBrowse link 8 19,884,480 19,888,643 RGD:9068941
ventricular cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MEF2C myocyte enhancer factor 2C JBrowse link 5 26,620,837 26,786,426 RGD:9068941
G MYOCD myocardin JBrowse link 17 43,578,967 43,681,659 RGD:9068941
G NRG1 neuregulin 1 JBrowse link 8 29,049,787 29,267,531 RGD:9068941
G RARA retinoic acid receptor alpha JBrowse link 17 17,156,923 17,205,451 RGD:9068941
G RARB retinoic acid receptor beta JBrowse link 3 25,660,850 25,830,372 RGD:9068941
G RXRA retinoid X receptor alpha JBrowse link 9 134,082,865 134,144,704 RGD:9068941
ventricular cardiac myofibril assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MEF2A myocyte enhancer factor 2A JBrowse link 15 97,428,808 97,579,092 RGD:9068941
G NKX2-5 NK2 homeobox 5 JBrowse link 5 175,492,288 175,495,514 RGD:9068941
G PROX1 prospero homeobox 1 JBrowse link 1 194,412,980 194,466,170 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15679
    developmental process 6086
      cellular developmental process 4160
        cell differentiation 3977
          cardiocyte differentiation 143
            cardiac muscle cell differentiation 111
              His-Purkinje system cell differentiation + 2
              atrial cardiac muscle cell differentiation + 3
              cardiac muscle cell development + 75
              cardiac muscle cell fate commitment + 8
              cardiac pacemaker cell differentiation + 5
              negative regulation of cardiac muscle cell differentiation + 17
              positive regulation of cardiac muscle cell differentiation + 19
              regulation of cardiac muscle cell differentiation + 36
              ventricular cardiac muscle cell differentiation + 18
Path 2
Term Annotations click to browse term
  biological_process 15679
    developmental process 6086
      anatomical structure development 5636
        multicellular organism development 5165
          system development 4609
            animal organ development 3394
              heart development 555
                cardiac muscle tissue development 209
                  cardiac muscle cell differentiation 111
                    His-Purkinje system cell differentiation + 2
                    atrial cardiac muscle cell differentiation + 3
                    cardiac muscle cell development + 75
                    cardiac muscle cell fate commitment + 8
                    cardiac pacemaker cell differentiation + 5
                    negative regulation of cardiac muscle cell differentiation + 17
                    positive regulation of cardiac muscle cell differentiation + 19
                    regulation of cardiac muscle cell differentiation + 36
                    ventricular cardiac muscle cell differentiation + 18
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.