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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac muscle cell differentiation
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Accession:GO:0055007 term browser browse the term
Definition:The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
Synonyms:exact_synonym: cardiomyocyte differentiation
 related_synonym: heart muscle cell differentiation


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cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACADM acyl-CoA dehydrogenase medium chain JBrowse link 6 70,852,223 70,881,979 RGD:13508589
G AKAP13 A-kinase anchoring protein 13 JBrowse link 3 49,076,313 49,310,564 RGD:13508589
G ARID1A AT-rich interaction domain 1A JBrowse link 2 73,331,606 73,401,151 RGD:13508589
G BMP4 bone morphogenetic protein 4 JBrowse link 8 29,997,563 30,254,307 RGD:13508589
G IFT20 intraflagellar transport 20 JBrowse link 9 42,581,117 42,587,830 RGD:13508589
G ITGB1 integrin subunit beta 1 JBrowse link 2 3,728,472 3,757,696 RGD:13508589
G MYOCD myocardin JBrowse link 5 36,674,476 36,774,435 RGD:13508589
G NOX4 NADPH oxidase 4 JBrowse link 21 10,615,153 10,782,927 RGD:13508589
G SLC9A1 solute carrier family 9 member A1 JBrowse link 2 73,054,742 73,103,364 RGD:13508589
G TBX5 T-box transcription factor 5 JBrowse link 26 11,462,541 11,549,699 RGD:13508589
G TSC1 TSC complex subunit 1 JBrowse link 9 51,409,307 51,459,546 RGD:13508589
atrial cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FHL2 four and a half LIM domains 2 JBrowse link 10 37,997,912 38,065,633 RGD:13508589
G NKX2-6 NK2 homeobox 6 JBrowse link 25 33,781,294 33,787,460 RGD:13508589
atrioventricular bundle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TBX3 T-box transcription factor 3 JBrowse link 26 11,694,885 11,709,594 RGD:13508589
atrioventricular node cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MAML1 mastermind like transcriptional coactivator 1 JBrowse link 11 1,915,622 1,927,598 RGD:13508589
G NKX2-5 NK2 homeobox 5 JBrowse link 4 39,240,755 39,254,585 RGD:13508589
atrioventricular node cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NKX2-5 NK2 homeobox 5 JBrowse link 4 39,240,755 39,254,585 RGD:13508589
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G WNT3A Wnt family member 3A JBrowse link 14 864,393 899,698 RGD:13508589
cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTN2 actinin alpha 2 JBrowse link 4 3,348,529 3,415,275 RGD:13508589
G ALPK3 alpha kinase 3 JBrowse link 3 54,064,963 54,119,720 RGD:13508589
G CAV3 caveolin 3 JBrowse link 20 9,384,901 9,398,055 RGD:13508589
G HNRNPU heterogeneous nuclear ribonucleoprotein U JBrowse link 7 35,832,956 35,842,898 RGD:13508589
G LRRC10 leucine rich repeat containing 10 JBrowse link 10 11,582,160 11,585,381 RGD:13508589
G MTOR mechanistic target of rapamycin kinase JBrowse link 2 84,818,893 84,939,283 RGD:13508589
G SGCB sarcoglycan beta JBrowse link 13 44,969,483 44,987,274 RGD:13508589
cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TBX3 T-box transcription factor 3 JBrowse link 26 11,694,885 11,709,594 RGD:13508589
cardiac muscle fiber development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CXADR CXADR Ig-like cell adhesion molecule JBrowse link 31 14,021,292 14,079,049 RGD:13508589
G LOC491446 myomesin-2 RGD:13508589
G MYO18B myosin XVIIIB JBrowse link 26 19,520,287 19,776,007 RGD:13508589
G MYOM1 myomesin 1 JBrowse link 7 69,703,057 69,837,987 RGD:13508589
G MYOM3 myomesin 3 JBrowse link 2 75,481,191 75,529,559 RGD:13508589
G TCAP titin-cap JBrowse link 9 22,811,792 22,812,980 RGD:13508589
G TTN titin JBrowse link 36 22,146,870 22,417,858 RGD:13508589
G ZMPSTE24 zinc metallopeptidase STE24 JBrowse link 15 2,669,546 2,708,480 RGD:13508589
cardiac muscle thin filament assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NEB nebulin JBrowse link 19 52,720,427 52,921,064 RGD:13508589
G NEBL nebulette JBrowse link 2 11,892,132 12,234,421 RGD:13508589
G NRAP nebulin related anchoring protein JBrowse link 28 24,522,285 24,592,267 RGD:13508589
cardiac myofibril assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTC1 actin alpha cardiac muscle 1 JBrowse link 30 2,514,825 2,519,398 RGD:13508589
G CSRP3 cysteine and glycine rich protein 3 JBrowse link 21 41,300,277 41,318,788 RGD:13508589
G FHOD3 formin homology 2 domain containing 3 JBrowse link 7 53,477,273 53,933,532 RGD:13508589
G LOC491446 myomesin-2 RGD:13508589
G MYLK3 myosin light chain kinase 3 JBrowse link 15 8,382,436 8,416,740 RGD:13508589
G MYOM1 myomesin 1 JBrowse link 7 69,703,057 69,837,987 RGD:13508589
G MYOM3 myomesin 3 JBrowse link 2 75,481,191 75,529,559 RGD:13508589
G PDGFRA platelet derived growth factor receptor alpha JBrowse link 13 46,729,722 46,775,828 RGD:13508589
G PDGFRB platelet derived growth factor receptor beta JBrowse link 4 58,925,922 58,963,639 RGD:13508589
G SRF serum response factor JBrowse link 12 11,664,441 11,673,846 RGD:13508589
G TCAP titin-cap JBrowse link 9 22,811,792 22,812,980 RGD:13508589
G TTN titin JBrowse link 36 22,146,870 22,417,858 RGD:13508589
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DKK1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 26 35,697,428 35,701,596 RGD:13508589
negative regulation of cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BMP2 bone morphogenetic protein 2 JBrowse link 24 15,199,667 15,211,509 RGD:13508589
G DLL1 delta like canonical Notch ligand 1 JBrowse link 12 72,265,078 72,272,347 RGD:13508589
G FRS2 fibroblast growth factor receptor substrate 2 JBrowse link 10 11,445,843 11,552,325 RGD:13508589
negative regulation of cardiac myofibril assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SMAD4 SMAD family member 4 JBrowse link 1 23,875,989 23,930,027 RGD:13508589
negative regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GSK3A glycogen synthase kinase 3 alpha JBrowse link 1 112,129,116 112,138,714 RGD:13508589
G PI16 peptidase inhibitor 16 JBrowse link 12 6,017,312 6,027,048 RGD:13508589
positive regulation of cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GREM1 gremlin 1, DAN family BMP antagonist JBrowse link 30 2,219,535 2,231,868 RGD:13508589
G MEF2C myocyte enhancer factor 2C JBrowse link 3 19,778,997 19,948,203 RGD:13508589
G MYOCD myocardin JBrowse link 5 36,674,476 36,774,435 RGD:13508589
G NRG1 neuregulin 1 JBrowse link 16 31,697,958 32,771,888 RGD:13508589
G WNT3A Wnt family member 3A JBrowse link 14 864,393 899,698 RGD:13508589
positive regulation of cardiac muscle fiber development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BMP4 bone morphogenetic protein 4 JBrowse link 8 29,997,563 30,254,307 RGD:13508589
positive regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EDN1 endothelin 1 JBrowse link 35 11,808,892 11,815,383 RGD:13508589
Purkinje myocyte differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NKX2-5 NK2 homeobox 5 JBrowse link 4 39,240,755 39,254,585 RGD:13508589
sinoatrial node cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BVES blood vessel epicardial substance JBrowse link 12 62,542,274 62,581,110 RGD:13508589
G TBX3 T-box transcription factor 3 JBrowse link 26 11,694,885 11,709,594 RGD:13508589
sinoatrial node cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MESP1 mesoderm posterior bHLH transcription factor 1 JBrowse link 3 52,738,333 52,739,962 RGD:13508589
ventricular cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATG5 autophagy related 5 JBrowse link 12 63,565,859 63,692,383 RGD:13508589
G BMP10 bone morphogenetic protein 10 JBrowse link 10 67,717,047 67,724,778 RGD:13508589
G FHL2 four and a half LIM domains 2 JBrowse link 10 37,997,912 38,065,633 RGD:13508589
G LMNA lamin A/C JBrowse link 7 41,702,491 41,719,870 RGD:13508589
G NKX2-6 NK2 homeobox 6 JBrowse link 25 33,781,294 33,787,460 RGD:13508589
ventricular cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MEF2C myocyte enhancer factor 2C JBrowse link 3 19,778,997 19,948,203 RGD:13508589
G MYOCD myocardin JBrowse link 5 36,674,476 36,774,435 RGD:13508589
G RARA retinoic acid receptor alpha JBrowse link 9 22,254,803 22,298,614 RGD:13508589
G RARB retinoic acid receptor beta JBrowse link 23 18,207,253 18,931,128 RGD:13508589
ventricular cardiac myofibril assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MEF2A myocyte enhancer factor 2A JBrowse link 3 41,012,103 41,177,588 RGD:13508589
G NKX2-5 NK2 homeobox 5 JBrowse link 4 39,240,755 39,254,585 RGD:13508589
G PROX1 prospero homeobox 1 JBrowse link 7 11,996,282 12,047,693 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13645
    developmental process 3739
      cellular developmental process 2498
        cell differentiation 2362
          cardiocyte differentiation 82
            cardiac muscle cell differentiation 62
              His-Purkinje system cell differentiation + 2
              atrial cardiac muscle cell differentiation + 2
              cardiac muscle cell development + 41
              cardiac muscle cell fate commitment + 4
              cardiac pacemaker cell differentiation + 5
              negative regulation of cardiac muscle cell differentiation + 7
              positive regulation of cardiac muscle cell differentiation + 7
              regulation of cardiac muscle cell differentiation + 14
              ventricular cardiac muscle cell differentiation + 12
Path 2
Term Annotations click to browse term
  biological_process 13645
    developmental process 3739
      anatomical structure development 3455
        multicellular organism development 3068
          system development 2799
            animal organ development 1971
              heart development 343
                cardiac muscle tissue development 120
                  cardiac muscle cell differentiation 62
                    His-Purkinje system cell differentiation + 2
                    atrial cardiac muscle cell differentiation + 2
                    cardiac muscle cell development + 41
                    cardiac muscle cell fate commitment + 4
                    cardiac pacemaker cell differentiation + 5
                    negative regulation of cardiac muscle cell differentiation + 7
                    positive regulation of cardiac muscle cell differentiation + 7
                    regulation of cardiac muscle cell differentiation + 14
                    ventricular cardiac muscle cell differentiation + 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.