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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac muscle cell differentiation
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Accession:GO:0055007 term browser browse the term
Definition:The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
Synonyms:exact_synonym: cardiomyocyte differentiation
 related_synonym: heart muscle cell differentiation


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cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARID1A AT-rich interaction domain 1A JBrowse link 6 84,049,729 84,124,302 RGD:14298760
G BMP2 bone morphogenetic protein 2 JBrowse link 17 15,750,487 15,762,982 RGD:14298760
G BMP4 bone morphogenetic protein 4 JBrowse link 1 183,415,989 183,422,888 RGD:14298760
G FOXP1 forkhead box P1 JBrowse link 13 52,346,844 52,974,358 RGD:14298760
G GATA6 GATA binding protein 6 JBrowse link 6 107,282,709 107,314,725 RGD:14298760
G IFT20 intraflagellar transport 20 JBrowse link 12 44,609,586 44,616,685 RGD:14298760
G ITGB1 integrin subunit beta 1 JBrowse link 10 56,078,393 56,130,608 RGD:14298760
G MYOCD myocardin JBrowse link 12 56,931,628 57,029,258 RGD:14298760
G NOX4 NADPH oxidase 4 JBrowse link 9 22,622,105 22,776,691 RGD:14298760
G SIK1 salt inducible kinase 1 JBrowse link 13 206,454,695 206,465,802 RGD:14298760
G SLC9A1 solute carrier family 9 member A1 JBrowse link 6 84,373,921 84,426,447 RGD:14298760
G SOX6 SRY-box transcription factor 6 JBrowse link 2 42,447,391 43,068,824 RGD:14298760
G TBX5 T-box transcription factor 5 JBrowse link 14 37,772,205 37,826,015 RGD:14298760
atrial cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FHL2 four and a half LIM domains 2 JBrowse link 3 49,389,900 49,448,459 RGD:14298760
G NKX2-6 NK2 homeobox 6 JBrowse link 14 7,811,200 7,815,553 RGD:14298760
atrioventricular bundle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TBX3 T-box transcription factor 3 JBrowse link 14 37,582,704 37,596,767 RGD:14298760
atrioventricular node cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MAML1 mastermind like transcriptional coactivator 1 JBrowse link 2 78,818,658 78,876,633 RGD:14298760
G NKX2-5 NK2 homeobox 5 JBrowse link 16 51,086,014 51,089,165 RGD:14298760
atrioventricular node cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NKX2-5 NK2 homeobox 5 JBrowse link 16 51,086,014 51,089,165 RGD:14298760
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G WNT3A Wnt family member 3A JBrowse link 2 51,153,978 51,203,678 RGD:14298760
cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ALPK2 alpha kinase 2 JBrowse link 1 162,175,241 162,308,074 RGD:14298760
G CAV3 caveolin 3 JBrowse link 13 65,117,868 65,130,886 RGD:14298760
G HNRNPU heterogeneous nuclear ribonucleoprotein U JBrowse link 10 17,475,266 17,497,060 RGD:14298760
G LRRC10 leucine rich repeat containing 10 JBrowse link 5 33,878,652 33,880,694 RGD:14298760
G MTOR mechanistic target of rapamycin kinase JBrowse link 6 71,286,989 71,412,913 RGD:14298760
cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACVR1 activin A receptor type 1 JBrowse link 15 64,749,478 64,891,653 RGD:14298760
G TBX3 T-box transcription factor 3 JBrowse link 14 37,582,704 37,596,767 RGD:14298760
cardiac muscle fiber development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ALPK3 alpha kinase 3 JBrowse link 7 52,667,342 52,718,775 RGD:14298760
G CXADR CXADR Ig-like cell adhesion molecule JBrowse link 13 182,134,416 182,185,977 RGD:14298760
G MYO18B myosin XVIIIB JBrowse link 14 43,467,823 43,687,729 RGD:14298760
G MYOM1 myomesin 1 JBrowse link 6 103,451,206 103,593,093 RGD:14298760
G MYOM2 myomesin 2 JBrowse link 15 33,529,559 33,606,928 RGD:14298760
G MYOM3 myomesin 3 JBrowse link 6 81,803,877 81,859,506 RGD:14298760
G SGCD sarcoglycan delta JBrowse link 16 66,447,982 67,481,709 RGD:14298760
G TCAP titin-cap JBrowse link 12 22,651,666 22,652,904 RGD:14298760
G ZMPSTE24 zinc metallopeptidase STE24 JBrowse link 6 96,008,307 96,057,131 RGD:14298760
cardiac muscle thin filament assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NEB nebulin JBrowse link 15 546,187 766,131 RGD:14298760
G NEBL nebulette JBrowse link 10 53,602,929 53,957,869 RGD:14298760
cardiac myofibril assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTC1 actin alpha cardiac muscle 1 JBrowse link 1 136,281,119 136,286,551 RGD:14298760
G ALPK3 alpha kinase 3 JBrowse link 7 52,667,342 52,718,775 RGD:14298760
G CSRP3 cysteine and glycine rich protein 3 JBrowse link 2 40,219,288 40,240,614 RGD:14298760
G FHOD3 formin homology 2 domain containing 3 JBrowse link 6 120,036,824 120,585,987 RGD:14298760
G MYL2 myosin light chain 2 JBrowse link 14 32,205,953 32,213,848 RGD:14298760
G MYLK3 myosin light chain kinase 3 JBrowse link 6 37,850,117 37,920,862 RGD:14298760
G MYOM1 myomesin 1 JBrowse link 6 103,451,206 103,593,093 RGD:14298760
G MYOM2 myomesin 2 JBrowse link 15 33,529,559 33,606,928 RGD:14298760
G MYOM3 myomesin 3 JBrowse link 6 81,803,877 81,859,506 RGD:14298760
G PDGFRA platelet derived growth factor receptor alpha JBrowse link 8 40,966,568 41,021,440 RGD:14298760
G PDGFRB platelet derived growth factor receptor beta JBrowse link 2 151,155,753 151,192,818 RGD:14298760
G SRF serum response factor JBrowse link 7 38,213,300 38,223,686 RGD:14298760
G TCAP titin-cap JBrowse link 12 22,651,666 22,652,904 RGD:14298760
cell growth involved in cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADRA1A adrenoceptor alpha 1A JBrowse link 14 10,623,391 10,733,378 RGD:14298760
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DKK1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 14 97,487,854 97,490,118 RGD:14298760
negative regulation of cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BMP2 bone morphogenetic protein 2 JBrowse link 17 15,750,487 15,762,982 RGD:14298760
G DLL1 delta like canonical Notch ligand 1 JBrowse link 1 198,815 211,346 RGD:14298760
G FRS2 fibroblast growth factor receptor substrate 2 JBrowse link 5 33,725,432 33,852,952 RGD:14298760
G FZD7 frizzled class receptor 7 JBrowse link 15 105,644,164 105,648,860 RGD:14298760
G SOX6 SRY-box transcription factor 6 JBrowse link 2 42,447,391 43,068,824 RGD:14298760
negative regulation of cardiac myofibril assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SMAD4 SMAD family member 4 JBrowse link 1 100,521,843 100,633,501 RGD:14298760
negative regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GSK3A glycogen synthase kinase 3 alpha JBrowse link 6 49,690,319 49,700,735 RGD:14298760
G PI16 peptidase inhibitor 16 JBrowse link 7 32,600,952 32,613,505 RGD:14298760
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RBPJ recombination signal binding protein for immunoglobulin kappa J region JBrowse link 8 19,933,035 20,166,746 RGD:14298760
positive regulation of cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EFNB2 ephrin B2 JBrowse link 11 74,188,337 74,232,768 RGD:14298760
G GREM1 gremlin 1, DAN family BMP antagonist JBrowse link 1 136,617,041 136,629,293 RGD:14298760
G MEF2C myocyte enhancer factor 2C JBrowse link 2 96,122,407 96,296,927 RGD:14298760
G MYOCD myocardin JBrowse link 12 56,931,628 57,029,258 RGD:14298760
G NRG1 neuregulin 1 JBrowse link 15 52,625,550 53,688,003 RGD:14298760
G TGFB1 transforming growth factor beta 1 JBrowse link 6 49,332,169 49,348,642 RGD:14298760
G WNT3A Wnt family member 3A JBrowse link 2 51,153,978 51,203,678 RGD:14298760
positive regulation of cardiac muscle fiber development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BMP4 bone morphogenetic protein 4 JBrowse link 1 183,415,989 183,422,888 RGD:14298760
positive regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EDN1 endothelin 1 JBrowse link 7 8,752,018 8,758,354 RGD:14298760
G IGF1 insulin like growth factor 1 JBrowse link 5 81,762,027 81,909,253 RGD:14298760
Purkinje myocyte differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NKX2-5 NK2 homeobox 5 JBrowse link 16 51,086,014 51,089,165 RGD:14298760
sinoatrial node cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BVES blood vessel epicardial substance JBrowse link 1 71,316,354 71,360,255 RGD:14298760
G TBX3 T-box transcription factor 3 JBrowse link 14 37,582,704 37,596,767 RGD:14298760
sinoatrial node cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MESP1 mesoderm posterior bHLH transcription factor 1 JBrowse link 7 55,322,016 55,327,600 RGD:14298760
ventricular cardiac muscle cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATG5 autophagy related 5 JBrowse link 1 72,343,950 72,520,402 RGD:14298760
G BMP10 bone morphogenetic protein 10 JBrowse link 3 73,519,904 73,530,448 RGD:14298760
G FHL2 four and a half LIM domains 2 JBrowse link 3 49,389,900 49,448,459 RGD:14298760
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 JBrowse link 1 37,219,887 37,231,321 RGD:14298760
G LMNA lamin A/C JBrowse link 4 93,899,019 93,927,255 RGD:14298760
G NKX2-6 NK2 homeobox 6 JBrowse link 14 7,811,200 7,815,553 RGD:14298760
ventricular cardiac muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MEF2C myocyte enhancer factor 2C JBrowse link 2 96,122,407 96,296,927 RGD:14298760
G RARA retinoic acid receptor alpha JBrowse link 12 22,047,449 22,085,759 RGD:14298760
G RXRA retinoid X receptor alpha JBrowse link 1 273,698,842 273,797,622 RGD:14298760
ventricular cardiac myofibril assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MEF2A myocyte enhancer factor 2A JBrowse link 1 138,398,270 138,508,639 RGD:14298760
G NKX2-5 NK2 homeobox 5 JBrowse link 16 51,086,014 51,089,165 RGD:14298760
G PROX1 prospero homeobox 1 JBrowse link 9 129,527,704 129,583,693 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14401
    developmental process 4177
      cellular developmental process 2851
        cell differentiation 2698
          cardiocyte differentiation 93
            cardiac muscle cell differentiation 70
              His-Purkinje system cell differentiation + 2
              atrial cardiac muscle cell differentiation + 2
              cardiac muscle cell development + 43
              cardiac muscle cell fate commitment + 6
              cardiac pacemaker cell differentiation + 5
              negative regulation of cardiac muscle cell differentiation + 9
              positive regulation of cardiac muscle cell differentiation + 11
              regulation of cardiac muscle cell differentiation + 20
              ventricular cardiac muscle cell differentiation + 12
Path 2
Term Annotations click to browse term
  biological_process 14401
    developmental process 4177
      anatomical structure development 3876
        multicellular organism development 3439
          system development 3140
            animal organ development 2282
              heart development 380
                cardiac muscle tissue development 138
                  cardiac muscle cell differentiation 70
                    His-Purkinje system cell differentiation + 2
                    atrial cardiac muscle cell differentiation + 2
                    cardiac muscle cell development + 43
                    cardiac muscle cell fate commitment + 6
                    cardiac pacemaker cell differentiation + 5
                    negative regulation of cardiac muscle cell differentiation + 9
                    positive regulation of cardiac muscle cell differentiation + 11
                    regulation of cardiac muscle cell differentiation + 20
                    ventricular cardiac muscle cell differentiation + 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.