Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:digestive system development
go back to main search page
Accession:GO:0055123 term browser browse the term
Definition:The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.


show annotations for term's descendants       view all columns           Sort by:
 
digestive system development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Barx1 BARX homeobox 1 JBrowse link NW_004937000 88,529 96,794 RGD:9068941
G Gip gastric inhibitory polypeptide JBrowse link NW_004936490 12,487,025 12,492,214 RGD:9068941
G Hip1r huntingtin interacting protein 1 related JBrowse link NW_004936558 1,778,862 1,804,071 RGD:9068941
G Wdpcp WD repeat containing planar cell polarity effector JBrowse link NW_004936491 8,238,644 8,749,172 RGD:9068941
G Wdr19 WD repeat domain 19 JBrowse link NW_004936482 6,863,592 6,937,810 RGD:9068941
cloaca development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahi1 Abelson helper integration site 1 JBrowse link NW_004936560 2,881,631 3,057,256 RGD:9068941
cloacal septation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link NW_004936697 1,054,237 1,061,468 RGD:9068941
G Tp63 tumor protein p63 JBrowse link NW_004936578 492,267 705,282 RGD:9068941
G Wnt11 Wnt family member 11 JBrowse link NW_004936498 4,909,041 4,927,482 RGD:9068941
determination of digestive tract left/right asymmetry term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccdc103 coiled-coil domain containing 103 JBrowse link NW_004936541 1,259,422 1,263,885 RGD:9068941
G Ccdc39 coiled-coil domain containing 39 JBrowse link NW_004936566 2,610,756 2,663,657 RGD:9068941
G Ccdc40 coiled-coil domain containing 40 JBrowse link NW_004936594 4,075,105 4,124,850 RGD:9068941
G Dnaaf1 dynein axonemal assembly factor 1 JBrowse link NW_004936641 3,656,331 3,674,907 RGD:9068941
G Megf8 multiple EGF like domains 8 JBrowse link NW_004936706 157,167 198,071 RGD:9068941
G Zic3 Zic family member 3 JBrowse link NW_004936513 9,780,895 9,792,865 RGD:9068941
determination of intestine left/right asymmetry term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nphp3 nephrocystin 3 JBrowse link NW_004936529 6,013,321 6,048,249 RGD:9068941
determination of stomach left/right asymmetry term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nphp3 nephrocystin 3 JBrowse link NW_004936529 6,013,321 6,048,249 RGD:9068941
digestive tract development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alx4 ALX homeobox 4 JBrowse link NW_004936562 4,316,550 4,326,022 RGD:9068941
G Cckbr cholecystokinin B receptor JBrowse link NW_004936842 329,551 341,491 RGD:9068941
G Ccnb1 cyclin B1 JBrowse link NW_004936480 400,287 407,677 RGD:9068941
G Chd8 chromodomain helicase DNA binding protein 8 JBrowse link NW_004936880 546,250 608,061 RGD:9068941
G Cldn18 claudin 18 JBrowse link NW_004936540 373,889 401,535 RGD:9068941
G Clmp CXADR like membrane protein JBrowse link NW_004936542 7,591,223 7,685,040 RGD:9068941
G Cobl cordon-bleu WH2 repeat protein JBrowse link NW_004936686 621,502 872,824 RGD:9068941
G Col3a1 collagen type III alpha 1 chain JBrowse link NW_004936506 8,886,494 8,923,921 RGD:9068941
G Dchs1 dachsous cadherin-related 1 JBrowse link NW_004936842 677,416 697,013 RGD:9068941
G Fat4 FAT atypical cadherin 4 JBrowse link NW_004936662 3,537,917 3,704,012 RGD:9068941
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link NW_004936486 10,506,680 10,606,272 RGD:9068941
G Foxf1 forkhead box F1 JBrowse link NW_004943883 4 1,756 RGD:9068941
G Hrh2 histamine receptor H2 JBrowse link NW_004936609 624,446 664,049 RGD:9068941
G Kit KIT proto-oncogene, receptor tyrosine kinase JBrowse link NW_004936482 17,162,854 17,238,319 RGD:9068941
G Lgr4 leucine rich repeat containing G protein-coupled receptor 4 JBrowse link NW_004936540 5,752,319 5,846,074 RGD:9068941
G LOC101969148 cytochrome P450 1A1 JBrowse link NW_004936471 33,682,730 33,688,332 RGD:9068941
G Mixl1 Mix paired-like homeobox JBrowse link NW_004936526 2,984,900 2,989,494 RGD:9068941
G Myocd myocardin JBrowse link NW_004936595 5,256,615 5,356,563 RGD:9068941
G Nipbl NIPBL cohesin loading factor JBrowse link NW_004936518 4,870,686 5,041,099 RGD:9068941
G Nkx2-2 NK2 homeobox 2 JBrowse link NW_004936620 3,961,106 3,962,910 RGD:9068941
G Nkx2-6 NK2 homeobox 6 JBrowse link NW_004936555 7,111,678 7,114,944 RGD:9068941
G Oxtr oxytocin receptor JBrowse link NW_004936602 4,241,743 4,259,866 RGD:9068941
G Pdgfc platelet derived growth factor C JBrowse link NW_004936576 3,357,399 3,555,828 RGD:9068941
G Pdx1 pancreatic and duodenal homeobox 1 JBrowse link NW_004936472 23,102,534 23,107,127 RGD:9068941
G Pkd1 polycystin 1, transient receptor potential channel interacting JBrowse link NW_004936694 1,923,383 1,958,160 RGD:9068941
G Rb1 RB transcriptional corepressor 1 JBrowse link NW_004936565 1,596,227 1,746,706 RGD:9068941
G Slc4a2 solute carrier family 4 member 2 JBrowse link NW_004936527 6,485,566 6,499,901 RGD:9068941
G Tgfb1 transforming growth factor beta 1 JBrowse link NW_004936661 3,742,080 3,758,266 RGD:9068941
G Tgfb3 transforming growth factor beta 3 JBrowse link NW_004936488 4,986,712 5,008,728 RGD:9068941
G Tgfbr2 transforming growth factor beta receptor 2 JBrowse link NW_004936473 21,324,669 21,409,430 RGD:9068941
digestive tract morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agr2 anterior gradient 2, protein disulphide isomerase family member JBrowse link NW_004936546 3,316,622 3,328,317 RGD:9068941
G Bbs7 Bardet-Biedl syndrome 7 JBrowse link NW_004936662 1,081,237 1,116,719 RGD:9068941
G Bcl2 BCL2 apoptosis regulator JBrowse link NW_004936497 2,209,136 2,373,580 RGD:9068941
G Egfr epidermal growth factor receptor JBrowse link NW_004936678 365,005 560,546 RGD:9068941
G Ephb3 EPH receptor B3 JBrowse link NW_004936578 5,286,580 5,297,369 RGD:9068941
G Gli1 GLI family zinc finger 1 JBrowse link NW_004936646 1,622,308 1,629,787 RGD:9068941
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link NW_004936495 5,770,988 5,816,157 RGD:9068941
G Nodal nodal growth differentiation factor JBrowse link NW_004936521 8,171,146 8,178,802 RGD:9068941
G Percc1 proline and glutamate rich with coiled coil 1 JBrowse link NW_004936694 2,475,981 2,479,716 RGD:9068941
G Sfrp1 secreted frizzled related protein 1 JBrowse link NW_004936785 1,276,478 1,320,397 RGD:9068941
G Sfrp2 secreted frizzled related protein 2 JBrowse link NW_004936576 604,174 612,440 RGD:9068941
G Sox10 SRY-box transcription factor 10 JBrowse link NW_004936492 3,173,770 3,183,423 RGD:9068941
G Stra6 signaling receptor and transporter of retinol STRA6 JBrowse link NW_004936471 33,224,174 33,245,076 RGD:9068941
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link NW_004936740 228,377 242,318 RGD:9068941
embryonic digestive tract development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh1a2 aldehyde dehydrogenase 1 family member A2 JBrowse link NW_004936471 19,175,997 19,263,335 RGD:9068941
G Cxcl8 C-X-C motif chemokine ligand 8 JBrowse link NW_004936598 1,779,471 1,781,353 RGD:9068941
G Fgf9 fibroblast growth factor 9 JBrowse link NW_004936720 282,291 316,629 RGD:9068941
G Foxf2 forkhead box F2 JBrowse link NW_004936633 2,538,209 2,543,649 RGD:9068941
G Gli2 GLI family zinc finger 2 JBrowse link NW_004936469 49,616,552 49,788,760 RGD:9068941
G Gli3 GLI family zinc finger 3 JBrowse link NW_004936478 17,129,922 17,403,630 RGD:9068941
G Pcsk5 proprotein convertase subtilisin/kexin type 5 JBrowse link NW_004936503 11,466,955 11,896,887 RGD:9068941
G Pkdcc protein kinase domain containing, cytoplasmic JBrowse link NW_004936508 9,550,201 9,559,493 RGD:9068941
G Rarb retinoic acid receptor beta JBrowse link NW_004936473 16,983,829 17,146,517 RGD:9068941
G Rarres2 retinoic acid receptor responder 2 JBrowse link NW_004936527 5,949,161 5,952,367 RGD:9068941
G Sall1 spalt like transcription factor 1 JBrowse link NW_004936475 4,106,663 4,121,356 RGD:9068941
G Sct secretin JBrowse link NW_004936888 459,168 459,919 RGD:9068941
G Stra6 signaling receptor and transporter of retinol STRA6 JBrowse link NW_004936471 33,224,174 33,245,076 RGD:9068941
G Tgfb2 transforming growth factor beta 2 JBrowse link NW_004936628 310,720 394,002 RGD:9068941
G Tnf tumor necrosis factor JBrowse link NW_004936727 1,936,066 1,937,766 RGD:9068941
embryonic digestive tract morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgf10 fibroblast growth factor 10 JBrowse link NW_004936480 18,114,231 18,195,884 RGD:9068941
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link NW_004936486 10,506,680 10,606,272 RGD:9068941
G Foxf1 forkhead box F1 JBrowse link NW_004943883 4 1,756 RGD:9068941
G Gli3 GLI family zinc finger 3 JBrowse link NW_004936478 17,129,922 17,403,630 RGD:9068941
G Hlx H2.0 like homeobox JBrowse link NW_004936650 1,416,825 1,422,595 RGD:9068941
G Hnf1b HNF1 homeobox B JBrowse link NW_004936490 649,551 702,448 RGD:9068941
G Id2 inhibitor of DNA binding 2 JBrowse link NW_004936532 5,236,175 5,238,689 RGD:9068941
G Ihh Indian hedgehog signaling molecule JBrowse link NW_004936569 1,474,693 1,480,562 RGD:9068941
G Nipbl NIPBL cohesin loading factor JBrowse link NW_004936518 4,870,686 5,041,099 RGD:9068941
G Ovol2 ovo like zinc finger 2 JBrowse link NW_004936485 2,096,495 2,128,002 RGD:9068941
G Pdgfra platelet derived growth factor receptor alpha JBrowse link NW_004936482 16,804,129 16,853,539 RGD:9068941
G Rbpms2 RNA binding protein, mRNA processing factor 2 JBrowse link NW_004936471 25,103,766 25,128,289 RGD:9068941
G Shh sonic hedgehog signaling molecule JBrowse link NW_004936527 10,033,095 10,042,713 RGD:9068941
G Shox2 short stature homeobox 2 JBrowse link NW_004936519 4,810,777 4,818,733 RGD:9068941
G Six2 SIX homeobox 2 JBrowse link NW_004936508 7,047,563 7,051,129 RGD:9068941
G Sox11 SRY-box transcription factor 11 JBrowse link NW_004937107 203,120 207,185 RGD:9068941
G Tcf21 transcription factor 21 JBrowse link NW_004936560 1,733,903 1,736,895 RGD:9068941
G Tcf7 transcription factor 7 JBrowse link NW_004936647 1,096,726 1,125,753 RGD:9068941
embryonic ectodermal digestive tract development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vps52 VPS52 subunit of GARP complex JBrowse link NW_004936476 25,594,168 25,612,044 RGD:9068941
embryonic ectodermal digestive tract morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxf1 forkhead box F1 JBrowse link NW_004943883 4 1,756 RGD:9068941
embryonic foregut morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr2b activin A receptor type 2B JBrowse link NW_004936473 27,816,366 27,822,555 RGD:9068941
G Ctnnb1 catenin beta 1 JBrowse link NW_004936473 29,999,542 30,034,610 RGD:9068941
G Epb41l5 erythrocyte membrane protein band 4.1 like 5 JBrowse link NW_004936469 50,329,564 50,443,532 RGD:9068941
G Foxf1 forkhead box F1 JBrowse link NW_004943883 4 1,756 RGD:9068941
G Gata4 GATA binding protein 4 JBrowse link NW_004936675 3,408,549 3,420,828 RGD:9068941
G Shh sonic hedgehog signaling molecule JBrowse link NW_004936527 10,033,095 10,042,713 RGD:9068941
G Smad2 SMAD family member 2 JBrowse link NW_004936497 14,723,199 14,812,160 RGD:9068941
G Smad3 SMAD family member 3 JBrowse link NW_004936471 27,080,662 27,185,861 RGD:9068941
G Sox17 SRY-box transcription factor 17 JBrowse link NW_004936496 1,248,582 1,251,406 RGD:9068941
embryonic hindgut morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dact1 dishevelled binding antagonist of beta catenin 1 JBrowse link NW_004936495 3,017,029 3,026,759 RGD:9068941
G Hoxd13 homeobox D13 JBrowse link NW_004936509 5,579,846 5,581,651 RGD:9068941
G Tcf7 transcription factor 7 JBrowse link NW_004936647 1,096,726 1,125,753 RGD:9068941
endodermal digestive tract morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Id2 inhibitor of DNA binding 2 JBrowse link NW_004936532 5,236,175 5,238,689 RGD:9068941
G Sox17 SRY-box transcription factor 17 JBrowse link NW_004936496 1,248,582 1,251,406 RGD:9068941
enteric smooth muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ednrb endothelin receptor type B JBrowse link NW_004936511 3,446,864 3,478,434 RGD:9068941
exocrine pancreas development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cela1 chymotrypsin like elastase 1 JBrowse link NW_004936512 8,901,674 8,919,819 RGD:9068941
G Igf2 insulin like growth factor 2 JBrowse link NW_004936816 972,902 981,232 RGD:9068941
G Insr insulin receptor JBrowse link NW_004936588 4,345,306 4,453,380 RGD:9068941
G Pdx1 pancreatic and duodenal homeobox 1 JBrowse link NW_004936472 23,102,534 23,107,127 RGD:9068941
G Ptf1a pancreas associated transcription factor 1a JBrowse link NW_004936520 4,978,896 4,980,648 RGD:9068941
G Srp54 signal recognition particle 54 JBrowse link NW_004936494 9,183,620 9,220,510 RGD:9068941
G Wls Wnt ligand secretion mediator JBrowse link NW_004936591 3,537,981 3,639,774 RGD:9068941
G Xbp1 X-box binding protein 1 JBrowse link NW_004936657 2,891,171 2,895,409 RGD:9068941
foregut morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Notch1 notch receptor 1 JBrowse link NW_004936669 1,292,016 1,334,061 RGD:9068941
hindgut development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ift172 intraflagellar transport 172 JBrowse link NW_004936493 5,108,437 5,145,160 RGD:9068941
hindgut morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gli2 GLI family zinc finger 2 JBrowse link NW_004936469 49,616,552 49,788,760 RGD:9068941
G Gli3 GLI family zinc finger 3 JBrowse link NW_004936478 17,129,922 17,403,630 RGD:9068941
G Shh sonic hedgehog signaling molecule JBrowse link NW_004936527 10,033,095 10,042,713 RGD:9068941
G Wnt5a Wnt family member 5A JBrowse link NW_004936473 6,031,627 6,052,211 RGD:9068941
intestinal epithelial cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1galt1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 JBrowse link NW_004936585 2,650,868 2,682,152 RGD:9068941
G Klf5 Kruppel like factor 5 JBrowse link NW_004936511 7,806,714 7,824,833 RGD:9068941
G Nkx3-2 NK3 homeobox 2 JBrowse link NW_004936477 13,999,045 14,001,659 RGD:9068941
G Prdm1 PR/SET domain 1 JBrowse link NW_004936564 2,594,362 2,690,680 RGD:9068941
G Spdef SAM pointed domain containing ETS transcription factor JBrowse link NW_004936476 24,563,591 24,571,739 RGD:9068941
G Tigar TP53 induced glycolysis regulatory phosphatase JBrowse link NW_004936606 4,518,525 4,540,109 RGD:9068941
G Yipf6 Yip1 domain family member 6 JBrowse link NW_004936777 169,794 193,155 RGD:9068941
intestinal epithelial cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbfa2t2 CBFA2/RUNX1 partner transcriptional co-repressor 2 JBrowse link NW_004936561 6,926,856 6,971,062 RGD:9068941
G Cdx2 caudal type homeobox 2 JBrowse link NW_004936472 23,137,936 23,141,205 RGD:9068941
G Gata4 GATA binding protein 4 JBrowse link NW_004936675 3,408,549 3,420,828 RGD:9068941
G Gata5 GATA binding protein 5 JBrowse link NW_004936514 10,061,675 10,070,541 RGD:9068941
G Gata6 GATA binding protein 6 JBrowse link NW_004936550 1,814,336 1,844,399 RGD:9068941
G Npy neuropeptide Y JBrowse link NW_004936478 1,289,437 1,296,819 RGD:9068941
G Ptk6 protein tyrosine kinase 6 JBrowse link NW_004936514 10,826,013 10,833,170 RGD:9068941
G Pyy peptide YY JBrowse link NW_004936541 470,806 471,518 RGD:9068941
G Sav1 salvador family WW domain containing protein 1 JBrowse link NW_004936495 14,955,234 14,977,720 RGD:9068941
intestinal epithelial cell maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn1a cyclin dependent kinase inhibitor 1A JBrowse link NW_004936476 22,717,308 22,725,127 RGD:9068941
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link NW_004936495 5,770,988 5,816,157 RGD:9068941
G Hoxa5 homeobox A5 JBrowse link NW_004936478 3,768,757 3,771,850 RGD:9068941
G Tyms thymidylate synthetase JBrowse link NW_004936550 33,797 42,233 RGD:9068941
midgut development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh1a2 aldehyde dehydrogenase 1 family member A2 JBrowse link NW_004936471 19,175,997 19,263,335 RGD:9068941
G Ass1 argininosuccinate synthase 1 JBrowse link NW_004936487 17,482,307 17,527,407 RGD:9068941
G Cps1 carbamoyl-phosphate synthase 1 JBrowse link NW_004936586 5,739,038 5,850,317 RGD:9068941
G Dab1 DAB adaptor protein 1 JBrowse link NW_004936522 3,498,395 4,612,560 RGD:9068941
G Egfr epidermal growth factor receptor JBrowse link NW_004936678 365,005 560,546 RGD:9068941
G Foxf1 forkhead box F1 JBrowse link NW_004943883 4 1,756 RGD:9068941
G Otc ornithine carbamoyltransferase JBrowse link NW_004936502 5,234,253 5,291,891 RGD:9068941
G Reg1a regenerating family member 1 alpha JBrowse link NW_004936556 4,873,331 4,875,608 RGD:9068941
G Smo smoothened, frizzled class receptor JBrowse link NW_004936579 5,893,064 5,917,021 RGD:9068941
G Wnt5a Wnt family member 5A JBrowse link NW_004936473 6,031,627 6,052,211 RGD:9068941
negative regulation of stomach neuroendocrine cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hes1 hes family bHLH transcription factor 1 JBrowse link NW_004936711 640,002 642,580 RGD:9068941
negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sfrp5 secreted frizzled related protein 5 JBrowse link NW_004936636 1,968,410 1,973,885 RGD:9068941
pharynx development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link NW_004936619 2,447,686 2,479,589 RGD:9068941
G Foxe1 forkhead box E1 JBrowse link NW_004936524 6,619,128 6,620,278 RGD:9068941
G Tbx2 T-box transcription factor 2 JBrowse link NW_004936490 2,769,264 2,778,342 RGD:9068941
post-embryonic digestive tract morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nkx2-3 NK2 homeobox 3 JBrowse link NW_004936636 529,669 532,237 RGD:9068941
posterior midgut development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ednrb endothelin receptor type B JBrowse link NW_004936511 3,446,864 3,478,434 RGD:9068941
G Ret ret proto-oncogene JBrowse link NW_004936617 2,927,185 2,980,594 RGD:9068941
stomach neuroendocrine cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ascl1 achaete-scute family bHLH transcription factor 1 JBrowse link NW_004936492 11,315,929 11,317,166 RGD:9068941
visceral mesoderm-endoderm interaction involved in midgut development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxl1 forkhead box L1 JBrowse link NW_004936641 2,226,489 2,227,613 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14835
    multicellular organismal process 6804
      multicellular organism development 5074
        system development 4548
          digestive system development 142
            digestive tract development + 130
            exocrine pancreas development 8
Path 2
Term Annotations click to browse term
  biological_process 14835
    developmental process 5955
      anatomical structure development 5521
        multicellular organism development 5074
          system development 4548
            digestive system development 142
              digestive tract development + 130
              exocrine pancreas development 8
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.