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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac muscle cell proliferation
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Accession:GO:0060038 term browser browse the term
Definition:The expansion of a cardiac muscle cell population by cell division.
Synonyms:exact_synonym: cardiac myocyte proliferation;   heart muscle cell proliferation
 related_synonym: cardiomyocyte proliferation


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cardiac muscle cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARID2 AT-rich interaction domain 2 IEA Ensembl GO_REF:0000107 NCBI chr12:45,729,706...45,908,037
Ensembl chr12:45,729,706...45,908,040
JBrowse link
G BMP10 bone morphogenetic protein 10 ISS UniProtKB GO_REF:0000024 NCBI chr 2:68,860,909...68,871,397
Ensembl chr 2:68,860,909...68,871,397
JBrowse link
G DIPK2A divergent protein kinase domain 2A IDA
IBA
(PMID:23784961)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:23784961 NCBI chr 3:143,971,798...143,992,368
Ensembl chr 3:143,971,798...144,048,719
Ensembl chr 3:143,971,798...144,048,719
JBrowse link
G FOXC1 forkhead box C1 IEA Ensembl GO_REF:0000107 NCBI chr 6:1,609,915...1,613,897
Ensembl chr 6:1,609,915...1,613,897
JBrowse link
G FOXC2 forkhead box C2 IEA Ensembl GO_REF:0000107 NCBI chr16:86,566,829...86,569,728
Ensembl chr16:86,566,829...86,569,728
JBrowse link
G NDRG4 NDRG family member 4 ISS BHF-UCL GO_REF:0000024 NCBI chr16:58,463,704...58,515,403
Ensembl chr16:58,462,846...58,513,628
JBrowse link
G NKX2-5 NK2 homeobox 5 IEA Ensembl GO_REF:0000107 NCBI chr 5:173,232,109...173,235,321
Ensembl chr 5:173,232,109...173,235,311
JBrowse link
G NOTCH1 notch receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha IEA Ensembl GO_REF:0000107 NCBI chr17:68,413,623...68,551,316
Ensembl chr17:68,511,780...68,551,319
JBrowse link
G RXRA retinoid X receptor alpha IEA Ensembl GO_REF:0000107 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G RXRB retinoid X receptor beta ISO (MGI:1101382|PMID:9428411) MGI PMID:9428411 MGI:1101382 NCBI chr 6:33,193,588...33,200,991
Ensembl chr 6:33,193,588...33,200,665
Ensembl chr 6:33,193,588...33,200,665
JBrowse link
G SMAD1 SMAD family member 1 IEA Ensembl GO_REF:0000107 NCBI chr 4:145,481,306...145,559,176
Ensembl chr 4:145,481,194...145,559,176
JBrowse link
G TENM4 teneurin transmembrane protein 4 IEA Ensembl GO_REF:0000107 NCBI chr11:78,652,829...79,441,030
Ensembl chr11:78,652,829...79,441,030
JBrowse link
G TGFB2 transforming growth factor beta 2 IDA (PMID:15896309) UniProtKB PMID:15896309 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TGFBR3 transforming growth factor beta receptor 3 ISS BHF-UCL GO_REF:0000024 NCBI chr 1:91,680,343...91,906,002
Ensembl chr 1:91,680,343...91,906,335
JBrowse link
negative regulation of cardiac muscle cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway ISO PMID:28948298 BHF-UCL PMID:28948298 RGD:13464260 NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,498...112,846,239
JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:139,371,807...139,374,648
Ensembl chr 6:139,371,807...139,374,648
JBrowse link
G CXADR CXADR Ig-like cell adhesion molecule IEA Ensembl GO_REF:0000107 NCBI chr21:17,513,016...17,636,213
Ensembl chr21:17,513,043...17,593,579
JBrowse link
G GJA1 gap junction protein alpha 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G HDAC2 histone deacetylase 2 ISO (MGI:3711360|PMID:17322895) MGI PMID:17322895 MGI:3711360 NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308
JBrowse link
G JARID2 jumonji and AT-rich interaction domain containing 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:15,245,975...15,522,042
Ensembl chr 6:15,246,069...15,522,042
JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 IEA Ensembl GO_REF:0000107 NCBI chr 1:215,002,920...215,237,093
Ensembl chr 1:215,005,775...215,237,090
Ensembl chr 1:215,005,775...215,237,090
JBrowse link
G MAPK11 mitogen-activated protein kinase 11 IEA Ensembl GO_REF:0000107 NCBI chr22:50,263,713...50,270,380
Ensembl chr22:50,263,713...50,270,767
JBrowse link
G MEIS1 Meis homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:66,435,125...66,573,869
Ensembl chr 2:66,433,452...66,573,869
JBrowse link
G MIR1-2 microRNA 1-2 ISO (MGI:5575655|PMID:17397913) MGI PMID:17397913 MGI:5575655 NCBI chr18:21,829,004...21,829,088
Ensembl chr18:21,829,004...21,829,088
JBrowse link
G NOG noggin ISS (PMID:10780858) BHF-UCL PMID:10780858 GO_REF:0000024 NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611
JBrowse link
G PTEN phosphatase and tensin homolog IEA Ensembl GO_REF:0000107 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G RBP4 retinol binding protein 4 ISS BHF-UCL GO_REF:0000024 NCBI chr10:93,591,694...93,601,744
Ensembl chr10:93,591,687...93,601,744
JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,991...3,115,187
JBrowse link
G SAV1 salvador family WW domain containing protein 1 IEA Ensembl GO_REF:0000107 NCBI chr14:50,633,104...50,668,306
Ensembl chr14:50,632,058...50,668,306
JBrowse link
G TBX5 T-box transcription factor 5 IDA (PMID:11161571) UniProtKB PMID:11161571 NCBI chr12:114,353,911...114,408,708
Ensembl chr12:114,353,931...114,408,442
Ensembl chr12:114,353,931...114,408,442
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 IEA Ensembl GO_REF:0000107 NCBI chr 3:30,606,472...30,694,142
Ensembl chr 3:30,606,601...30,694,142
Ensembl chr 3:30,606,601...30,694,142
JBrowse link
G TP73 tumor protein p73 IMP (PMID:18634800) MGI PMID:18634800 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201
JBrowse link
G VGLL4 vestigial like family member 4 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 3:11,556,067...11,720,715
Ensembl chr 3:11,556,069...11,771,350
JBrowse link
positive regulation of cardiac muscle cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP10 bone morphogenetic protein 10 ISS (PMID:10072785) BHF-UCL PMID:10072785 NCBI chr 2:68,860,909...68,871,397
Ensembl chr 2:68,860,909...68,871,397
JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A ISS BHF-UCL GO_REF:0000024 NCBI chr10:86,755,786...86,927,969
Ensembl chr10:86,756,601...86,932,838
Ensembl chr10:86,756,601...86,932,838
JBrowse link
G CCNB1 cyclin B1 IEA Ensembl GO_REF:0000107 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CDK1 cyclin dependent kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISS UniProtKB GO_REF:0000024 NCBI chr 2:211,375,717...212,538,802
Ensembl chr 2:211,375,717...212,538,841
JBrowse link
G FGF2 fibroblast growth factor 2 IDA (PMID:9553078) BHF-UCL PMID:9553078 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G FGF9 fibroblast growth factor 9 IEA Ensembl GO_REF:0000107 NCBI chr13:21,671,073...21,704,501
Ensembl chr13:21,671,073...21,704,498
JBrowse link
G FGFR1 fibroblast growth factor receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 ISS UniProtKB GO_REF:0000024 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,334...121,598,458
Ensembl chr10:121,478,334...121,598,458
JBrowse link
G GATA4 GATA binding protein 4 ISO (MGI:3833786|PMID:19084512) MGI PMID:19084512 MGI:3833786 NCBI chr 8:11,676,931...11,760,002
Ensembl chr 8:11,676,959...11,760,002
JBrowse link
G GATA6 GATA binding protein 6 IEA Ensembl GO_REF:0000107 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
JBrowse link
G GLI1 GLI family zinc finger 1 IDA (PMID:28583401) BHF-UCL PMID:28583401 NCBI chr12:57,459,785...57,472,451
Ensembl chr12:57,459,785...57,472,268
JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:125,747,639...125,762,243
Ensembl chr 6:125,747,664...125,761,269
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 IEA Ensembl GO_REF:0000107 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G MEF2C myocyte enhancer factor 2C ISS UniProtKB GO_REF:0000024 NCBI chr 5:88,717,117...88,904,105
Ensembl chr 5:88,717,117...88,904,257
JBrowse link
G NCAM1 neural cell adhesion molecule 1 ISO RGD PMID:19853610 RGD:2325979 NCBI chr11:112,961,420...113,278,436
Ensembl chr11:112,961,247...113,278,436
JBrowse link
G NOTCH1 notch receptor 1 ISS BHF-UCL GO_REF:0000024 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G NRG1 neuregulin 1 IDA (PMID:9553078) BHF-UCL PMID:9553078 NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666
JBrowse link
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase IDA (PMID:21474815) BHF-UCL PMID:21474815 NCBI chr 6:37,170,152...37,175,428
Ensembl chr 6:37,170,152...37,175,428
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region ISS BHF-UCL GO_REF:0000024 NCBI chr 4:26,163,458...26,435,131
Ensembl chr 4:26,163,455...26,435,131
JBrowse link
G TBX2 T-box transcription factor 2 ISS BHF-UCL GO_REF:0000024 NCBI chr17:61,399,843...61,409,466
Ensembl chr17:61,399,843...61,409,466
JBrowse link
G TBX20 T-box transcription factor 20 ISS BHF-UCL GO_REF:0000024 NCBI chr 7:35,199,936...35,254,100
Ensembl chr 7:35,202,430...35,254,100
JBrowse link
G TBX5 T-box transcription factor 5 IEA Ensembl GO_REF:0000107 NCBI chr12:114,353,911...114,408,708
Ensembl chr12:114,353,931...114,408,442
Ensembl chr12:114,353,931...114,408,442
JBrowse link
G TGFBR3 transforming growth factor beta receptor 3 ISS BHF-UCL GO_REF:0000024 NCBI chr 1:91,680,343...91,906,002
Ensembl chr 1:91,680,343...91,906,335
JBrowse link
G WNT2 Wnt family member 2 IEA Ensembl GO_REF:0000107 NCBI chr 7:117,275,451...117,323,058
Ensembl chr 7:117,275,451...117,323,152
JBrowse link
G YAP1 Yes1 associated transcriptional regulator IEA Ensembl GO_REF:0000107 NCBI chr11:102,109,957...102,233,424
Ensembl chr11:102,110,447...102,233,424
JBrowse link
G ZFPM2 zinc finger protein, FOG family member 2 ISS BHF-UCL GO_REF:0000024 NCBI chr 8:105,318,438...105,804,539
Ensembl chr 8:104,590,733...105,804,539
JBrowse link
regulation of cardiac muscle cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1A bone morphogenetic protein receptor type 1A ISS BHF-UCL GO_REF:0000024 NCBI chr10:86,755,786...86,927,969
Ensembl chr10:86,756,601...86,932,838
Ensembl chr10:86,756,601...86,932,838
JBrowse link
G FGF20 fibroblast growth factor 20 IEA Ensembl GO_REF:0000107 NCBI chr 8:16,992,181...17,002,345
Ensembl chr 8:16,992,181...17,002,345
JBrowse link
G FOXP1 forkhead box P1 ISO (MGI:4829405|PMID:20713518) MGI PMID:20713518 MGI:4829405 NCBI chr 3:70,954,708...71,583,983
Ensembl chr 3:70,952,817...71,583,993
Ensembl chr 3:70,952,817...71,583,993
JBrowse link
G GATA4 GATA binding protein 4 ISO (MGI:3581473|PMID:15902305) MGI PMID:15902305 MGI:3581473 NCBI chr 8:11,676,931...11,760,002
Ensembl chr 8:11,676,959...11,760,002
JBrowse link
G MAPK11 mitogen-activated protein kinase 11 ISO (MGI:5288131|PMID:21768366) MGI PMID:21768366 MGI:5288131 NCBI chr22:50,263,713...50,270,380
Ensembl chr22:50,263,713...50,270,767
JBrowse link
G MIR133A1 microRNA 133a-1 ISO (MGI:3820745|PMID:19015276) MGI PMID:19015276 MGI:3820745 NCBI chr18:21,825,698...21,825,785
Ensembl chr18:21,825,698...21,825,785
JBrowse link
G MIR133A2 microRNA 133a-2 ISO (MGI:3820745|PMID:19015276) MGI PMID:19015276 MGI:3820745 NCBI chr20:62,564,912...62,565,013
Ensembl chr20:62,564,912...62,565,013
JBrowse link
G NKX2-5 NK2 homeobox 5 IEA Ensembl GO_REF:0000107 NCBI chr 5:173,232,109...173,235,321
Ensembl chr 5:173,232,109...173,235,311
JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ISS BHF-UCL GO_REF:0000024 NCBI chr 9:99,104,038...99,154,192
Ensembl chr 9:99,104,038...99,154,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18673
    developmental process 7467
      developmental growth 835
        cardiac muscle tissue growth 112
          cardiac muscle cell proliferation 63
            negative regulation of cardiac muscle cell proliferation 19
            positive regulation of cardiac muscle cell proliferation + 28
            regulation of cardiac muscle cell proliferation + 52
Path 2
Term Annotations click to browse term
  biological_process 18673
    developmental process 7467
      anatomical structure development 6874
        multicellular organism development 6347
          system development 5750
            circulatory system development 1281
              heart development 707
                cardiac muscle tissue development 257
                  cardiac muscle tissue growth 112
                    cardiac muscle cell proliferation 63
                      negative regulation of cardiac muscle cell proliferation 19
                      positive regulation of cardiac muscle cell proliferation + 28
                      regulation of cardiac muscle cell proliferation + 52
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.