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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac muscle cell proliferation
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Accession:GO:0060038 term browser browse the term
Definition:The expansion of a cardiac muscle cell population by cell division.
Synonyms:exact_synonym: cardiac myocyte proliferation;   heart muscle cell proliferation
 related_synonym: cardiomyocyte proliferation


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cardiac muscle cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARID2 AT-rich interaction domain 2 IEA Ensembl GO_REF:0000107 NCBI chr 5:76,637,385...76,800,155
Ensembl chr 5:76,637,202...76,847,316
JBrowse link
G BMP10 bone morphogenetic protein 10 IEA Ensembl GO_REF:0000107 NCBI chr 3:73,519,904...73,530,448
Ensembl chr 3:73,519,934...73,529,977
JBrowse link
G DIPK2A divergent protein kinase domain 2A IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:84,634,716...84,656,112
Ensembl chr13:84,634,030...84,657,371
JBrowse link
G FOXC1 forkhead box C1 IEA Ensembl GO_REF:0000107 NCBI chr 7:837,088...840,593
Ensembl chr 7:837,171...838,805
JBrowse link
G FOXC2 forkhead box C2 IEA Ensembl GO_REF:0000107 NCBI chr 6:2,552,141...2,555,041
Ensembl chr 6:2,552,862...2,554,367
JBrowse link
G NKX2-5 NK2 homeobox 5 IEA Ensembl GO_REF:0000107 NCBI chr16:51,086,014...51,089,165
Ensembl chr16:51,086,011...51,089,165
JBrowse link
G NOTCH1 notch receptor 1 IEA Ensembl GO_REF:0000107
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha IEA Ensembl GO_REF:0000107 NCBI chr12:11,662,344...11,681,490
Ensembl chr12:11,662,347...11,681,202
JBrowse link
G RXRA retinoid X receptor alpha IEA Ensembl GO_REF:0000107 NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,503...273,797,622
JBrowse link
G RXRB retinoid X receptor beta ISO (MGI:1101382|PMID:9428411) MGI PMID:9428411 MGI:1101382 NCBI chr 7:25,236,005...25,242,842
Ensembl chr 7:25,236,007...25,242,875
JBrowse link
G SMAD1 SMAD family member 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:82,907,557...82,987,909
Ensembl chr 8:82,908,527...82,968,994
JBrowse link
G TENM4 teneurin transmembrane protein 4 ISO (MGI:5429684|PMID:17350578) MGI PMID:17350578 MGI:5429684 NCBI chr 9:13,040,615...13,826,957 JBrowse link
G TGFB2 transforming growth factor beta 2 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,424...8,405,771
JBrowse link
G TGFBR3 transforming growth factor beta receptor 3 ISO (MGI:2663364|PMID:12773577) BHF-UCL PMID:12773577 MGI:2663364 NCBI chr 4:125,109,939...125,310,788
Ensembl chr 4:125,101,190...125,316,796
JBrowse link
negative regulation of cardiac muscle cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway ISO PMID:28948298 BHF-UCL PMID:28948298 RGD:13464260 NCBI chr 2:116,913,354...116,985,303
Ensembl chr 2:116,812,582...117,034,912
JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 ISO PMID:26240138 BHF-UCL PMID:26240138 RGD:13210532 NCBI chr 1:25,155,652...25,158,517
Ensembl chr 1:25,155,664...25,160,279
JBrowse link
G CXADR CXADR Ig-like cell adhesion molecule IEA Ensembl GO_REF:0000107 NCBI chr13:182,134,416...182,185,977
Ensembl chr13:182,134,566...182,193,681
JBrowse link
G GJA1 gap junction protein alpha 1 ISO RGD PMID:19377854 RGD:7207421 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,515...41,002,137
JBrowse link
G HDAC2 histone deacetylase 2 ISO (MGI:3711360|PMID:17322895) MGI PMID:17322895 MGI:3711360 NCBI chr 1:79,867,713...79,901,597
Ensembl chr 1:79,863,094...79,901,585
JBrowse link
G JARID2 jumonji and AT-rich interaction domain containing 2 ISO PMID:26298346 BHF-UCL PMID:26298346 RGD:11522645 NCBI chr 7:11,358,243...11,601,715
Ensembl chr 7:11,357,961...11,602,104
JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 ISO RGD PMID:24705172 RGD:9831164 NCBI chr 9:128,429,232...128,659,662
Ensembl chr 9:128,357,160...128,659,717
JBrowse link
G MAPK11 mitogen-activated protein kinase 11 IEA Ensembl GO_REF:0000107 NCBI chr 5:420,848...428,103
Ensembl chr 5:421,783...428,100
JBrowse link
G MEIS1 Meis homeobox 1 ISO PMID:28111633 BHF-UCL PMID:28111633 RGD:12911005 NCBI chr 3:75,485,024...75,625,855
Ensembl chr 3:75,485,022...75,625,040
JBrowse link
G NOG noggin ISS UniProt GO_REF:0000024 NCBI chr12:32,891,321...32,892,206
Ensembl chr12:32,891,321...32,892,206
JBrowse link
G PTEN phosphatase and tensin homolog ISO (MGI:5584062|PMID:23575307) BHF-UCL PMID:23575307 MGI:5584062 NCBI chr14:99,929,590...100,021,619 JBrowse link
G RBP4 retinol binding protein 4 ISO (MGI:2655947|PMID:12663486) BHF-UCL PMID:12663486 MGI:2655947 NCBI chr14:105,037,360...105,044,552
Ensembl chr14:105,036,770...105,044,765
JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,236...1,880,699
JBrowse link
G SAV1 salvador family WW domain containing protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:180,404,871...180,434,458
Ensembl chr 1:180,395,544...180,434,384
JBrowse link
G TBX5 T-box transcription factor 5 IEA Ensembl GO_REF:0000107 NCBI chr14:37,772,205...37,826,015
Ensembl chr14:37,773,605...37,824,400
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 ISO RGD PMID:15537505 RGD:1601597 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,491...16,878,165
JBrowse link
G TP73 tumor protein p73 IEA Ensembl GO_REF:0000107 NCBI chr 6:65,169,770...65,228,997
Ensembl chr 6:65,177,682...65,228,992
JBrowse link
G VGLL4 vestigial like family member 4 IEA Ensembl GO_REF:0000107 NCBI chr13:67,698,082...67,873,119
Ensembl chr13:67,698,082...67,876,257
JBrowse link
positive regulation of cardiac muscle cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP10 bone morphogenetic protein 10 IEA Ensembl GO_REF:0000107 NCBI chr 3:73,519,904...73,530,448
Ensembl chr 3:73,519,934...73,529,977
JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A IEA Ensembl GO_REF:0000107 NCBI chr14:87,743,270...87,891,790
Ensembl chr14:87,742,459...87,891,793
JBrowse link
G CCNB1 cyclin B1 ISO RGD PMID:15253691 RGD:2301353 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,381
JBrowse link
G CDK1 cyclin dependent kinase 1 ISO RGD PMID:15253691 RGD:2301353 NCBI chr14:64,233,945...64,255,290
Ensembl chr14:64,233,988...64,395,453
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 IEA Ensembl GO_REF:0000107 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,973,037...114,696,375
JBrowse link
G FGF2 fibroblast growth factor 2 ISO (PMID:9553078) BHF-UCL
RGD
PMID:8603495, PMID:9553078 RGD:8655650 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,878...101,343,916
JBrowse link
G FGF9 fibroblast growth factor 9 IEA Ensembl GO_REF:0000107 NCBI chr11:1,554,648...1,581,938
Ensembl chr11:1,554,763...1,582,408
JBrowse link
G FGFR1 fibroblast growth factor receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr15:48,053,895...48,106,634
Ensembl chr15:48,053,340...48,106,746
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 ISO (MGI:3527351|PMID:15621532) MGI PMID:15621532 MGI:3527351 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,710...131,579,703
JBrowse link
G GATA4 GATA binding protein 4 ISO (MGI:3833786|PMID:19084512) MGI PMID:19084512 MGI:3833786 NCBI chr14:14,858,470...14,938,156
Ensembl chr14:14,858,159...14,939,941
JBrowse link
G GATA6 GATA binding protein 6 IEA Ensembl GO_REF:0000107 NCBI chr 6:107,282,709...107,314,725
Ensembl chr 6:107,282,847...107,314,634
JBrowse link
G GLI1 GLI family zinc finger 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:22,736,325...22,747,421
Ensembl chr 5:22,732,516...22,747,421
JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 IEA Ensembl GO_REF:0000107 NCBI chr 1:37,219,887...37,231,321
Ensembl chr 1:37,219,883...37,231,385
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO RGD PMID:26884868 RGD:13800890 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 IEA Ensembl GO_REF:0000107 NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,104...31,862,038
JBrowse link
G MEF2C myocyte enhancer factor 2C ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 2:96,122,407...96,296,927
Ensembl chr 2:96,122,407...96,296,842
JBrowse link
G NCAM1 neural cell adhesion molecule 1 ISO RGD PMID:19853610 RGD:2325979 NCBI chr 9:40,628,602...40,960,605
Ensembl chr 9:40,628,750...40,960,608
JBrowse link
G NOTCH1 notch receptor 1 IEA Ensembl GO_REF:0000107
G NRG1 neuregulin 1 ISO (PMID:9553078) BHF-UCL PMID:9553078 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,627,334...53,688,332
JBrowse link
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase ISO (PMID:21474815) BHF-UCL PMID:21474815 NCBI chr 7:32,788,246...32,793,882
Ensembl chr 7:32,788,005...32,793,880
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region IEA Ensembl GO_REF:0000107 NCBI chr 8:19,933,035...20,166,746
Ensembl chr 8:19,922,779...20,166,755
JBrowse link
G TBX2 T-box transcription factor 2 IEA Ensembl GO_REF:0000107 NCBI chr12:36,878,662...36,887,513
Ensembl chr12:36,878,675...36,887,513
JBrowse link
G TBX20 T-box transcription factor 20 IEA Ensembl GO_REF:0000107 NCBI chr18:38,635,603...38,681,690
Ensembl chr18:38,635,617...38,677,208
JBrowse link
G TBX5 T-box transcription factor 5 IEA Ensembl GO_REF:0000107 NCBI chr14:37,772,205...37,826,015
Ensembl chr14:37,773,605...37,824,400
JBrowse link
G TGFBR3 transforming growth factor beta receptor 3 ISO (MGI:2663364|PMID:12773577) BHF-UCL PMID:12773577 MGI:2663364 NCBI chr 4:125,109,939...125,310,788
Ensembl chr 4:125,101,190...125,316,796
JBrowse link
G WNT2 Wnt family member 2 IEA Ensembl GO_REF:0000107 NCBI chr18:28,945,825...28,993,969
Ensembl chr18:28,946,277...29,028,107
JBrowse link
G YAP1 Yes1 associated transcriptional regulator IEA Ensembl GO_REF:0000107 NCBI chr 9:32,811,629...32,924,926
Ensembl chr 9:32,811,416...32,925,603
JBrowse link
G ZFPM2 zinc finger protein, FOG family member 2 IEA Ensembl GO_REF:0000107 NCBI chr 4:31,607,968...31,996,226
Ensembl chr 4:31,606,751...32,094,340
JBrowse link
regulation of cardiac muscle cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1A bone morphogenetic protein receptor type 1A ISO (MGI:3040576|PMID:15073157) BHF-UCL PMID:15073157 MGI:3040576 NCBI chr14:87,743,270...87,891,790
Ensembl chr14:87,742,459...87,891,793
JBrowse link
G FGF20 fibroblast growth factor 20 IEA Ensembl GO_REF:0000107 NCBI chr17:4,691,448...4,700,367
Ensembl chr17:4,691,448...4,700,367
JBrowse link
G FOXP1 forkhead box P1 IEA Ensembl GO_REF:0000107 NCBI chr13:52,346,844...52,974,358
Ensembl chr13:52,347,849...52,974,261
JBrowse link
G GATA4 GATA binding protein 4 ISO (MGI:3581473|PMID:15902305) MGI PMID:15902305 MGI:3581473 NCBI chr14:14,858,470...14,938,156
Ensembl chr14:14,858,159...14,939,941
JBrowse link
G MAPK11 mitogen-activated protein kinase 11 ISO (MGI:5288131|PMID:21768366) MGI PMID:21768366 MGI:5288131 NCBI chr 5:420,848...428,103
Ensembl chr 5:421,783...428,100
JBrowse link
G MIR133A-1 microRNA mir-133a-1 ISO (MGI:3820745|PMID:19015276) MGI PMID:19015276 MGI:3820745 NCBI chr17:61,904,781...61,904,883
Ensembl chr17:61,904,781...61,904,883
JBrowse link
G MIR133A-2 microRNA mir-133a-2 ISO (MGI:3820745|PMID:19015276) MGI PMID:19015276 MGI:3820745 NCBI chr 6:106,998,899...106,998,971
Ensembl chr 6:106,998,896...106,998,982
JBrowse link
G NKX2-5 NK2 homeobox 5 IEA Ensembl GO_REF:0000107 NCBI chr16:51,086,014...51,089,165
Ensembl chr16:51,086,011...51,089,165
JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:240,842,735...240,918,267
Ensembl chr 1:240,859,270...240,918,528
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16552
    developmental process 6306
      developmental growth 796
        cardiac muscle tissue growth 110
          cardiac muscle cell proliferation 61
            negative regulation of cardiac muscle cell proliferation 18
            positive regulation of cardiac muscle cell proliferation + 28
            regulation of cardiac muscle cell proliferation + 51
Path 2
Term Annotations click to browse term
  biological_process 16552
    developmental process 6306
      anatomical structure development 5846
        multicellular organism development 5344
          system development 4968
            circulatory system development 1183
              heart development 667
                cardiac muscle tissue development 250
                  cardiac muscle tissue growth 110
                    cardiac muscle cell proliferation 61
                      negative regulation of cardiac muscle cell proliferation 18
                      positive regulation of cardiac muscle cell proliferation + 28
                      regulation of cardiac muscle cell proliferation + 51
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.