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ONTOLOGY REPORT - ANNOTATIONS


Term:Wnt signaling pathway, planar cell polarity pathway
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Accession:GO:0060071 term browser browse the term
Definition:The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
Synonyms:exact_synonym: PCP pathway;   Wnt receptor signaling pathway, planar cell polarity pathway;   Wnt receptor signalling pathway, planar cell polarity pathway;   Wnt-activated signaling pathway, planar cell polarity pathway;   planar cell polarity pathway
 related_synonym: Wnt-JNK signaling pathway;   Wnt-PCP signaling pathway;   non-canonical Wnt signaling pathway


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Wnt signaling pathway, planar cell polarity pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cthrc1 collagen triple helix repeat containing 1 JBrowse link 7 77,966,722 77,977,004 RGD:1624291
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1624291
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:1624291
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:1624291
G Fzd6 frizzled class receptor 6 JBrowse link 7 77,898,329 77,931,034 RGD:1624291
G Med12 mediator complex subunit 12 JBrowse link X 71,174,653 71,197,812 RGD:1624291
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1624291
G Ror2 receptor tyrosine kinase-like orphan receptor 2 JBrowse link 17 11,953,552 12,134,386 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:8554067
RGD:1624291
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:1624291
G Wnt9b Wnt family member 9B JBrowse link 10 91,785,892 91,808,061 RGD:1624291
negative regulation of planar cell polarity pathway involved in axis elongation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:1624291
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
negative regulation of planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
planar cell polarity pathway involved in axis elongation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in axon guidance term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 JBrowse link 8 117,620,293 117,648,034 RGD:1624291
G Fzd3 frizzled class receptor 3 JBrowse link 15 48,601,259 48,670,257 RGD:1624291
G Ryk receptor-like tyrosine kinase JBrowse link 8 111,326,339 111,398,640 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1600115
RGD:1624291
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:1624291
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in cardiac right atrium morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in gastrula mediolateral intercalation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in heart morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 JBrowse link 7 126,774,010 126,914,085 RGD:1624291
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1624291
RGD:13792537
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:1624291
RGD:13792537
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:1624291
RGD:13792537
G Fzd1 frizzled class receptor 1 JBrowse link 4 26,470,864 26,475,262 RGD:1624291
RGD:1600115
G Fzd2 frizzled class receptor 2 JBrowse link 10 90,550,147 90,552,057 RGD:1624291
RGD:1600115
G Grhl3 grainyhead-like transcription factor 3 JBrowse link 5 153,893,039 153,925,045 RGD:1624291
G Ptk7 protein tyrosine kinase 7 JBrowse link 9 16,662,588 16,729,888 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in outflow tract morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in pericardium morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
planar cell polarity pathway involved in ventricular septum morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
positive regulation of Wnt signaling pathway, planar cell polarity pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:1624291
G Ankrd6 ankyrin repeat domain 6 JBrowse link 5 48,052,610 48,167,568 RGD:1624291
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1624291
RGD:1600115
G Gpc3 glypican 3 JBrowse link X 139,579,268 139,947,093 RGD:8554067
RGD:1600115
RGD:1624291
G Mllt3 MLLT3, super elongation complex subunit JBrowse link 5 106,103,498 106,202,559 RGD:1624291
G Nkd1 NKD inhibitor of WNT signaling pathway 1 JBrowse link 19 19,434,720 19,509,087 RGD:1624291
G Plekha4 pleckstrin homology domain containing A4 JBrowse link 1 101,517,702 101,540,802 RGD:1624291
regulation of Wnt signaling pathway, planar cell polarity pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dact1 dishevelled-binding antagonist of beta-catenin 1 JBrowse link 6 93,740,440 93,751,003 RGD:1624291
RGD:13792537
G Mks1 MKS transition zone complex subunit 1 JBrowse link 10 75,149,814 75,160,481 RGD:1624291
RGD:1600115
G Znrf3 zinc and ring finger 3 JBrowse link 14 85,527,099 85,586,294 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    signaling 7456
      cell-cell signaling 1888
        cell-cell signaling by wnt 433
          Wnt signaling pathway 430
            non-canonical Wnt signaling pathway 53
              Wnt signaling pathway, planar cell polarity pathway 37
                planar cell polarity pathway involved in axis elongation + 6
                planar cell polarity pathway involved in axon guidance 6
                planar cell polarity pathway involved in cardiac muscle cell fate commitment 0
                planar cell polarity pathway involved in gastrula mediolateral intercalation 2
                planar cell polarity pathway involved in heart morphogenesis + 3
                planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation 0
                planar cell polarity pathway involved in neural tube closure + 14
                positive regulation of Wnt signaling pathway, planar cell polarity pathway 8
                regulation of Wnt signaling pathway, planar cell polarity pathway + 15
                regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division 0
Path 2
Term Annotations click to browse term
  biological_process 19336
    developmental process 6638
      anatomical structure development 6107
        anatomical structure morphogenesis 2821
          tissue morphogenesis 701
            morphogenesis of an epithelium 571
              morphogenesis of a polarized epithelium 81
                establishment of planar polarity 55
                  regulation of establishment of planar polarity 39
                    Wnt signaling pathway, planar cell polarity pathway 37
                      planar cell polarity pathway involved in axis elongation + 6
                      planar cell polarity pathway involved in axon guidance 6
                      planar cell polarity pathway involved in cardiac muscle cell fate commitment 0
                      planar cell polarity pathway involved in gastrula mediolateral intercalation 2
                      planar cell polarity pathway involved in heart morphogenesis + 3
                      planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation 0
                      planar cell polarity pathway involved in neural tube closure + 14
                      positive regulation of Wnt signaling pathway, planar cell polarity pathway 8
                      regulation of Wnt signaling pathway, planar cell polarity pathway + 15
                      regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.