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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060314 term browser browse the term
Definition:Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


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regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 IDA
ISS
ISO
GO_REF:0000024
(PMID:22067155)
UniProt
RGD
PMID:22067155, PMID:15628869 GO_REF:0000024, RGD:7241270 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 IDA
ISO
ISS
(PMID:22067155)
GO_REF:0000024
RGD
UniProt
PMID:22067155, PMID:15628869 GO_REF:0000024, RGD:7241270 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Calm3 calmodulin 3 IDA
ISS
ISO
GO_REF:0000024
(PMID:22067155)
UniProt
RGD
PMID:22067155, PMID:15628869 GO_REF:0000024, RGD:7241270 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Dmd dystrophin ISO (MGI:MGI:4420848|PMID:20080623) RGD PMID:20080623 MGI:MGI:4420848 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO (PMID:7592869)
(MGI:MGI:1195585|PMID:9461216)
RGD PMID:7592869, PMID:9461216 MGI:MGI:1195585 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B NOT ISO (PMID:17921453)
(PMID:20431056), (PMID:7592869)
(MGI:MGI:3836106|PMID:17921453)
(MGI:MGI:3621834|PMID:12837242)
RGD PMID:7592869, PMID:12837242, PMID:17921453, PMID:20431056 MGI:MGI:3621834, MGI:MGI:3836106 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Hrc histidine rich calcium binding protein ISO UniProtKB:B9EIW1 (PMID:24125847) RGD PMID:24125847 NCBI chr 1:101,324,788...101,328,391
Ensembl chr 1:101,324,652...101,328,435
JBrowse link
G Jph3 junctophilin 3 ISO (MGI:MGI:3654871|PMID:16809425) RGD PMID:16809425 MGI:MGI:3654871 NCBI chr19:54,553,419...54,613,477
Ensembl chr19:54,553,419...54,613,477
JBrowse link
G Jsrp1 junctional sarcoplasmic reticulum protein 1 ISO
IBA
(MGI:MGI:3625379|PMID:16638807)
PMID:21873635
RGD PMID:16638807, PMID:21873635 MGI:MGI:3625379, RGD:13792537 NCBI chr 7:11,769,950...11,774,373
Ensembl chr 7:11,769,400...11,774,387
JBrowse link
G Pde4d phosphodiesterase 4D ISO
IEA
(MGI:MGI:3690823|PMID:16213210)
GO_REF:0000107
RGD
Ensembl
PMID:16213210 GO_REF:0000107, MGI:MGI:3690823 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pln phospholamban ISO MGI:MGI:2158357 (MGI:MGI:1352171|PMID:10603936) RGD PMID:10603936 MGI:MGI:1352171 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904
JBrowse link
G Selenon selenoprotein N ISO (PMID:18713863) RGD PMID:18713863 NCBI chr 5:152,748,497...152,765,489
Ensembl chr 5:152,750,284...152,762,165
JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 ISO
ISS
(PMID:26164367)
GO_REF:0000024
RGD
UniProt
PMID:26164367 GO_REF:0000024 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 ISS
ISO
GO_REF:0000024
(PMID:26164367)
UniProt
RGD
PMID:26164367 GO_REF:0000024 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Calm3 calmodulin 3 ISO
ISS
(PMID:26164367)
GO_REF:0000024
RGD
UniProt
PMID:26164367 GO_REF:0000024 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Casq2 calsequestrin 2 ISO
IEA
IMP
(PMID:16601229)
(PMID:15041652)
GO_REF:0000107
PMID:17569730
RGD
Ensembl
PMID:15041652, PMID:16601229, PMID:17569730 GO_REF:0000107, RGD:2314601 NCBI chr 2:204,512,361...204,568,643
Ensembl chr 2:204,512,302...204,568,656
JBrowse link
G Clic2 chloride intracellular channel 2 ISO (PMID:15147738), (PMID:15916532) RGD PMID:15147738, PMID:15916532 NCBI chr20:295,338...310,363
Ensembl chr20:295,250...310,380
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A NOT ISO (PMID:12443530) RGD PMID:12443530 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B ISO (PMID:12443530) RGD PMID:12443530 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Gstm2 glutathione S-transferase mu 2 ISO
IEA
(PMID:17023043), (PMID:22406107)
GO_REF:0000107
RGD
Ensembl
PMID:17023043, PMID:22406107 GO_REF:0000107 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm7 glutathione S-transferase, mu 7 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:210,720,719...210,726,179
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISO
IEA
(PMID:11035031)
GO_REF:0000107
RGD
Ensembl
PMID:11035031 GO_REF:0000107 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO (MGI:MGI:3708075|PMID:17404231) RGD PMID:17404231 MGI:MGI:3708075 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Sri sorcin ISO (PMID:17699613) RGD PMID:17699613 NCBI chr 4:23,004,657...23,029,233
Ensembl chr 4:23,006,243...23,018,983
JBrowse link
positive regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap6 A-kinase anchoring protein 6 IDA PMID:12709444 BHF-UCL PMID:12709444 RGD:8554839 NCBI chr 6:73,553,111...73,991,992
Ensembl chr 6:73,553,210...73,990,534
JBrowse link
G Calm1 calmodulin 1 ISO (PMID:20226167) RGD PMID:20226167 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 ISO (PMID:20226167) RGD PMID:20226167 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Calm3 calmodulin 3 ISO (PMID:20226167) RGD PMID:20226167 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Gstm2 glutathione S-transferase mu 2 ISO
IEA
(PMID:17023043)
GO_REF:0000107
RGD
Ensembl
PMID:17023043 GO_REF:0000107 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm7 glutathione S-transferase, mu 7 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:210,720,719...210,726,179
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISO
IEA
(PMID:11035031)
GO_REF:0000107
RGD
Ensembl
PMID:11035031 GO_REF:0000107 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Jph2 junctophilin 2 ISO (PMID:20095964) RGD PMID:20095964 NCBI chr 3:159,709,998...159,776,536
Ensembl chr 3:159,712,325...159,775,643
JBrowse link
G Trdn triadin ISO
IBA
(PMID:15041652), (PMID:15731460)
PMID:21873635
RGD PMID:15041652, PMID:15731460, PMID:21873635 RGD:13792537 NCBI chr 1:25,403,390...25,787,664
Ensembl chr 1:25,403,390...25,839,345
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological quality 4284
        regulation of calcium ion transport into cytosol 117
          regulation of release of sequestered calcium ion into cytosol 88
            regulation of ryanodine-sensitive calcium-release channel activity 22
              negative regulation of ryanodine-sensitive calcium-release channel activity 12
              positive regulation of ryanodine-sensitive calcium-release channel activity 9
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological quality 4284
        homeostatic process 2090
          chemical homeostasis 1328
            ion homeostasis 882
              cellular ion homeostasis 724
                cellular cation homeostasis 711
                  cellular metal ion homeostasis 644
                    cellular calcium ion homeostasis 512
                      regulation of cytosolic calcium ion concentration 409
                        positive regulation of cytosolic calcium ion concentration 360
                          calcium ion transport into cytosol 176
                            calcium ion transmembrane import into cytosol 152
                              release of sequestered calcium ion into cytosol 127
                                regulation of release of sequestered calcium ion into cytosol 88
                                  regulation of ryanodine-sensitive calcium-release channel activity 22
                                    negative regulation of ryanodine-sensitive calcium-release channel activity 12
                                    positive regulation of ryanodine-sensitive calcium-release channel activity 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.