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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060315 term browser browse the term
Definition:Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


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negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 ISO
ISS
(PMID:26164367)
GO_REF:0000024
RGD
UniProt
PMID:26164367 GO_REF:0000024 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 ISS
ISO
GO_REF:0000024
(PMID:26164367)
UniProt
RGD
PMID:26164367 GO_REF:0000024 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Calm3 calmodulin 3 ISO
ISS
(PMID:26164367)
GO_REF:0000024
RGD
UniProt
PMID:26164367 GO_REF:0000024 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Casq2 calsequestrin 2 ISO
IEA
IMP
(PMID:16601229)
(PMID:15041652)
GO_REF:0000107
PMID:17569730
RGD
Ensembl
PMID:15041652, PMID:16601229, PMID:17569730 GO_REF:0000107, RGD:2314601 NCBI chr 2:204,512,361...204,568,643
Ensembl chr 2:204,512,302...204,568,656
JBrowse link
G Clic2 chloride intracellular channel 2 ISO (PMID:15147738), (PMID:15916532) RGD PMID:15147738, PMID:15916532 NCBI chr20:295,338...310,363
Ensembl chr20:295,250...310,380
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A NOT ISO (PMID:12443530) RGD PMID:12443530 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B ISO (PMID:12443530) RGD PMID:12443530 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Gstm2 glutathione S-transferase mu 2 ISO
IEA
(PMID:17023043), (PMID:22406107)
GO_REF:0000107
RGD
Ensembl
PMID:17023043, PMID:22406107 GO_REF:0000107 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm7 glutathione S-transferase, mu 7 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:210,720,719...210,726,179
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISO
IEA
(PMID:11035031)
GO_REF:0000107
RGD
Ensembl
PMID:11035031 GO_REF:0000107 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO (MGI:MGI:3708075|PMID:17404231) RGD PMID:17404231 MGI:MGI:3708075 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Sri sorcin ISO (PMID:17699613) RGD PMID:17699613 NCBI chr 4:23,004,657...23,029,233
Ensembl chr 4:23,006,243...23,018,983
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      negative regulation of cellular process 5156
        negative regulation of calcium ion transport into cytosol 22
          negative regulation of release of sequestered calcium ion into cytosol 18
            negative regulation of ryanodine-sensitive calcium-release channel activity 12
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological quality 4280
        homeostatic process 2077
          chemical homeostasis 1334
            ion homeostasis 887
              cellular ion homeostasis 730
                cellular cation homeostasis 717
                  cellular metal ion homeostasis 649
                    cellular calcium ion homeostasis 515
                      regulation of cytosolic calcium ion concentration 412
                        positive regulation of cytosolic calcium ion concentration 361
                          calcium ion transport into cytosol 176
                            calcium ion transmembrane import into cytosol 152
                              release of sequestered calcium ion into cytosol 127
                                regulation of release of sequestered calcium ion into cytosol 88
                                  negative regulation of release of sequestered calcium ion into cytosol 18
                                    negative regulation of ryanodine-sensitive calcium-release channel activity 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.