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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060315 term browser browse the term
Definition:Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


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negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G CALM2 calmodulin 2 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chr2A:47,274,722...47,290,861 JBrowse link
G CALM3 calmodulin 3 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G CASQ2 calsequestrin 2 ISO (PMID:15041652)
(PMID:16601229)
PMID:17569730
BHF-UCL PMID:15041652, PMID:16601229, PMID:17569730 RGD:2314601 NCBI chr 1:86,795,392...86,864,196
Ensembl chr 1:121,844,097...121,913,311
JBrowse link
G CLIC2 chloride intracellular channel 2 ISO (PMID:15147738), (PMID:15916532) BHF-UCL PMID:15147738, PMID:15916532 NCBI chr  X:144,742,839...144,851,524
Ensembl chr  X:154,581,649...154,641,515
JBrowse link
G FKBP1A FKBP prolyl isomerase 1A NOT ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr20:1,519,330...1,548,473 JBrowse link
G FKBP1B FKBP prolyl isomerase 1B ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr2A:24,047,287...24,065,765
Ensembl chr2A:24,145,893...24,159,082
JBrowse link
G GSTM2 glutathione S-transferase mu 2 ISO (PMID:17023043), (PMID:22406107) BHF-UCL PMID:17023043, PMID:22406107 NCBI chr 1:112,043,201...112,050,810 JBrowse link
G GSTO1 glutathione S-transferase omega 1 ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr10:100,853,682...100,866,892
Ensembl chr10:104,313,024...104,325,733
JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel ISO (MGI:MGI:3708075|PMID:17404231) MGI PMID:17404231 MGI:MGI:3708075 NCBI chr 4:80,295,243...80,365,271
Ensembl chr 4:91,019,734...91,086,775
JBrowse link
G SRI sorcin ISO (PMID:17699613) BHF-UCL PMID:17699613 NCBI chr 7:80,199,719...80,214,733
Ensembl chr 7:93,850,496...93,864,029
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12564
    cellular process 11665
      negative regulation of cellular process 4407
        negative regulation of calcium ion transport into cytosol 21
          negative regulation of release of sequestered calcium ion into cytosol 17
            negative regulation of ryanodine-sensitive calcium-release channel activity 11
Path 2
Term Annotations click to browse term
  biological_process 12564
    biological regulation 9168
      regulation of biological quality 3506
        homeostatic process 1794
          chemical homeostasis 1105
            ion homeostasis 723
              cellular ion homeostasis 575
                cellular cation homeostasis 563
                  cellular metal ion homeostasis 514
                    cellular calcium ion homeostasis 423
                      regulation of cytosolic calcium ion concentration 328
                        positive regulation of cytosolic calcium ion concentration 290
                          calcium ion transport into cytosol 165
                            calcium ion transmembrane import into cytosol 140
                              release of sequestered calcium ion into cytosol 116
                                regulation of release of sequestered calcium ion into cytosol 87
                                  negative regulation of release of sequestered calcium ion into cytosol 17
                                    negative regulation of ryanodine-sensitive calcium-release channel activity 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.