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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060315 term browser browse the term
Definition:Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


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negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chrNW_004955438:12,842,437...12,854,028
Ensembl chrNW_004955438:12,842,437...12,854,028
JBrowse link
G Calm2 calmodulin 2 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chrNW_004955441:13,973,147...13,988,665 JBrowse link
G Calm3 calmodulin 3 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chrNW_004955574:672,441...680,924
Ensembl chrNW_004955574:672,300...680,924
JBrowse link
G Casq2 calsequestrin 2 ISO (PMID:15041652)
PMID:17569730
(PMID:16601229)
BHF-UCL PMID:15041652, PMID:16601229, PMID:17569730 RGD:2314601 NCBI chrNW_004955435:18,941,975...18,996,027
Ensembl chrNW_004955435:18,941,936...18,996,200
JBrowse link
G Clic2 chloride intracellular channel 2 ISO (PMID:15147738), (PMID:15916532) BHF-UCL PMID:15147738, PMID:15916532 NCBI chrNW_004955594:374,332...393,802
Ensembl chrNW_004955594:374,208...393,389
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A NOT ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chrNW_004955596:580,106...606,210 JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chrNW_004955469:6,263,271...6,274,823
Ensembl chrNW_004955469:6,263,271...6,277,767
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO (MGI:MGI:3708075|PMID:17404231) MGI PMID:17404231 MGI:MGI:3708075 NCBI chrNW_004955474:1,831,221...1,868,170
Ensembl chrNW_004955474:1,833,701...1,868,817
JBrowse link
G Sri sorcin ISO (PMID:17699613) BHF-UCL PMID:17699613 NCBI chrNW_004955432:5,541,311...5,559,781
Ensembl chrNW_004955432:5,541,311...5,560,294
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11892
    cellular process 11094
      negative regulation of cellular process 4219
        negative regulation of calcium ion transport into cytosol 18
          negative regulation of release of sequestered calcium ion into cytosol 15
            negative regulation of ryanodine-sensitive calcium-release channel activity 9
Path 2
Term Annotations click to browse term
  biological_process 11892
    biological regulation 8722
      regulation of biological quality 3365
        homeostatic process 1718
          chemical homeostasis 1052
            ion homeostasis 688
              cellular ion homeostasis 547
                cellular cation homeostasis 535
                  cellular metal ion homeostasis 487
                    cellular calcium ion homeostasis 401
                      regulation of cytosolic calcium ion concentration 308
                        positive regulation of cytosolic calcium ion concentration 270
                          calcium ion transport into cytosol 155
                            calcium ion transmembrane import into cytosol 132
                              release of sequestered calcium ion into cytosol 108
                                regulation of release of sequestered calcium ion into cytosol 82
                                  negative regulation of release of sequestered calcium ion into cytosol 15
                                    negative regulation of ryanodine-sensitive calcium-release channel activity 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.