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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060315 term browser browse the term
Definition:Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


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negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chr 8:61,398,231...61,408,874
Ensembl chr 8:61,398,244...61,406,195
JBrowse link
G CALM2 calmodulin 2 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chr10:49,299,698...49,314,533 JBrowse link
G CALM3 calmodulin 3 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chr 1:109,284,729...109,294,491
Ensembl chr 1:109,286,155...109,294,391
JBrowse link
G CASQ2 calsequestrin 2 IDA
IEA
(PMID:15041652) BHF-UCL
Ensembl
PMID:15041652 GO_REF:0000107 NCBI chr17:53,233,966...53,299,093
Ensembl chr17:53,224,438...53,299,708
JBrowse link
G CLIC2 chloride intracellular channel 2 IEA Ensembl GO_REF:0000107 NCBI chr  X:123,268,867...123,291,467
Ensembl chr  X:123,268,867...123,291,467
JBrowse link
G FKBP1A FKBP prolyl isomerase 1A NOT ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr24:19,618,581...19,643,685
Ensembl chr24:19,618,558...19,643,046
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B IEA Ensembl GO_REF:0000107 NCBI chr17:18,534,295...18,544,973
Ensembl chr17:18,534,741...18,544,943
JBrowse link
G GSTO1 glutathione S-transferase omega 1 IEA Ensembl GO_REF:0000107 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880
JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel IEA Ensembl GO_REF:0000107 NCBI chr32:11,383,441...11,437,603
Ensembl chr32:11,383,424...11,435,438
JBrowse link
G SRI sorcin ISO (PMID:17699613) BHF-UCL PMID:17699613 NCBI chr14:14,257,375...14,274,816
Ensembl chr14:14,260,052...14,274,801
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16187
    cellular process 15463
      negative regulation of cellular process 4876
        negative regulation of calcium ion transport into cytosol 20
          negative regulation of release of sequestered calcium ion into cytosol 16
            negative regulation of ryanodine-sensitive calcium-release channel activity 10
Path 2
Term Annotations click to browse term
  biological_process 16187
    biological regulation 11555
      regulation of biological quality 4007
        homeostatic process 1960
          chemical homeostasis 1249
            ion homeostasis 831
              cellular ion homeostasis 673
                cellular cation homeostasis 660
                  cellular metal ion homeostasis 594
                    cellular calcium ion homeostasis 484
                      regulation of cytosolic calcium ion concentration 384
                        positive regulation of cytosolic calcium ion concentration 335
                          calcium ion transport into cytosol 174
                            calcium ion transmembrane import into cytosol 150
                              release of sequestered calcium ion into cytosol 122
                                regulation of release of sequestered calcium ion into cytosol 84
                                  negative regulation of release of sequestered calcium ion into cytosol 16
                                    negative regulation of ryanodine-sensitive calcium-release channel activity 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.