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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060315 term browser browse the term
Definition:Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


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negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 IDA
ISS
(PMID:26164367) UniProtKB
BHF-UCL
PMID:26164367 GO_REF:0000024 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
JBrowse link
G CALM2 calmodulin 2 IDA
ISS
(PMID:26164367) UniProtKB
BHF-UCL
PMID:26164367 GO_REF:0000024 NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,083...47,176,921
JBrowse link
G CALM3 calmodulin 3 IDA
ISS
(PMID:26164367) UniProtKB
BHF-UCL
PMID:26164367 GO_REF:0000024 NCBI chr19:46,601,074...46,610,782
Ensembl chr19:46,601,074...46,610,782
JBrowse link
G CASQ2 calsequestrin 2 IDA
ISS
(PMID:16601229) BHF-UCL PMID:16601229 GO_REF:0000024 NCBI chr 1:115,700,021...115,768,714
Ensembl chr 1:115,700,021...115,768,714
Ensembl chr 1:115,700,021...115,768,714
JBrowse link
G CLIC2 chloride intracellular channel 2 IEA
IDA
(PMID:15147738), (PMID:15916532) InterPro
BHF-UCL
PMID:15147738, PMID:15916532 GO_REF:0000002 NCBI chr  X:155,276,211...155,334,614
Ensembl chr  X:155,276,211...155,334,657
JBrowse link
G FKBP1A FKBP prolyl isomerase 1A NOT IDA (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr20:1,368,977...1,393,172
Ensembl chr20:1,368,978...1,393,172
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B IDA (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr 2:24,033,205...24,067,743
Ensembl chr 2:24,049,701...24,063,681
JBrowse link
G GSTM2 glutathione S-transferase mu 2 IDA (PMID:17023043), (PMID:22406107) BHF-UCL PMID:17023043, PMID:22406107 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTO1 glutathione S-transferase omega 1 IDA (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459
JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel ISS BHF-UCL GO_REF:0000024 NCBI chr 4:88,007,635...88,077,779
Ensembl chr 4:88,007,635...88,077,777
JBrowse link
G SRI sorcin IDA (PMID:17699613) BHF-UCL PMID:17699613 NCBI chr 7:88,205,115...88,226,976
Ensembl chr 7:88,205,118...88,226,993
Ensembl chr 7:88,205,118...88,226,993
JBrowse link
G TRDN triadin TAS (PMID:17569730) BHF-UCL PMID:17569730 NCBI chr 6:123,216,339...123,636,950
Ensembl chr 6:123,216,339...123,637,093
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    cellular process 17686
      negative regulation of cellular process 5521
        negative regulation of calcium ion transport into cytosol 22
          negative regulation of release of sequestered calcium ion into cytosol 17
            negative regulation of ryanodine-sensitive calcium-release channel activity 12
Path 2
Term Annotations click to browse term
  biological_process 18670
    biological regulation 13308
      regulation of biological quality 4611
        homeostatic process 2208
          chemical homeostasis 1392
            ion homeostasis 931
              cellular ion homeostasis 768
                cellular cation homeostasis 755
                  cellular metal ion homeostasis 672
                    cellular calcium ion homeostasis 528
                      regulation of cytosolic calcium ion concentration 415
                        positive regulation of cytosolic calcium ion concentration 372
                          calcium ion transport into cytosol 190
                            calcium ion transmembrane import into cytosol 165
                              release of sequestered calcium ion into cytosol 136
                                regulation of release of sequestered calcium ion into cytosol 96
                                  negative regulation of release of sequestered calcium ion into cytosol 17
                                    negative regulation of ryanodine-sensitive calcium-release channel activity 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.