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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac epithelial to mesenchymal transition
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Accession:GO:0060317 term browser browse the term
Definition:A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
Synonyms:exact_synonym: heart epithelial to mesenchymal transition


show annotations for term's descendants       view all columns           Sort by:
 
cardiac epithelial to mesenchymal transition term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam15 ADAM metallopeptidase domain 15 JBrowse link 2 188,661,831 188,672,337 RGD:1624291
RGD:1600115
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
RGD:1600115
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1624291
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 JBrowse link 1 29,191,170 29,201,257 RGD:1624291
G Heyl hes-related family bHLH transcription factor with YRPW motif-like JBrowse link 5 140,923,914 140,940,905 RGD:1624291
G LOC103690035 TGF-beta receptor type-1-like JBrowse link 5 64,565,358 64,585,219 RGD:1600115
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
G Olfm1 olfactomedin 1 JBrowse link 3 6,761,031 6,798,739 RGD:1600115
G Rtn4 reticulon 4 JBrowse link 14 114,126,931 114,174,459 RGD:1624291
RGD:1600115
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
RGD:1600115
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1600115
G Tgfbr3 transforming growth factor beta receptor 3 JBrowse link 14 3,506,416 3,680,508 RGD:1624291
RGD:1600115
G Wnt16 Wnt family member 16 JBrowse link 4 49,369,246 49,388,156 RGD:1624291
RGD:1600115
G Wnt2 Wnt family member 2 JBrowse link 4 45,286,845 45,332,899 RGD:1624291
RGD:1600115
endocardial cushion to mesenchymal transition term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvrl1 activin A receptor like type 1 JBrowse link 7 142,769,942 142,787,336 RGD:1624291
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:1624291
RGD:1600115
endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:1624291
RGD:1600115
G Erg ETS transcription factor ERG JBrowse link 11 35,645,317 35,749,637 RGD:1624291
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1624291
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 JBrowse link 1 29,191,170 29,201,257 RGD:1624291
RGD:1600115
epithelial to mesenchymal transition involved in cardiac fibroblast development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:10400865
G Spry1 sprouty RTK signaling antagonist 1 JBrowse link 2 124,400,689 124,405,331 RGD:10400865
epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Fgf8 fibroblast growth factor 8 JBrowse link 1 265,492,949 265,498,965 RGD:1624291
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1624291
G Heyl hes-related family bHLH transcription factor with YRPW motif-like JBrowse link 5 140,923,914 140,940,905 RGD:1624291
RGD:1600115
G Msx1 msh homeobox 1 JBrowse link 14 77,712,262 77,716,061 RGD:1624291
RGD:1600115
G Msx2 msh homeobox 2 JBrowse link 17 11,683,862 11,689,527 RGD:1624291
RGD:1600115
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
RGD:1600115
G Rbpj recombination signal binding protein for immunoglobulin kappa J region JBrowse link 14 59,657,738 59,865,427 RGD:1624291
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1624291
RGD:1600115
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:1624291
RGD:1600115
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:1624291
G Tmem100 transmembrane protein 100 JBrowse link 10 77,537,340 77,543,710 RGD:1624291
RGD:1600115
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
positive regulation of cardiac epithelial to mesenchymal transition term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Jag1 jagged canonical Notch ligand 1 JBrowse link 3 130,079,361 130,114,781 RGD:13601997
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:13601997
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
RGD:1600115
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:1624291
RGD:1600115
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1624291
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:1624291
RGD:1600115
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18157
    developmental process 6524
      anatomical structure morphogenesis 2762
        animal organ morphogenesis 1117
          heart morphogenesis 279
            cardiac epithelial to mesenchymal transition 37
              endocardial cushion to mesenchymal transition + 8
              epithelial to mesenchymal transition involved in cardiac fibroblast development 2
              epithelial to mesenchymal transition involved in coronary vasculature morphogenesis 0
              epithelial to mesenchymal transition involved in endocardial cushion formation + 20
              negative regulation of cardiac epithelial to mesenchymal transition + 2
              positive regulation of cardiac epithelial to mesenchymal transition + 8
              regulation of cardiac epithelial to mesenchymal transition + 11
Path 2
Term Annotations click to browse term
  biological_process 18157
    developmental process 6524
      anatomical structure development 6010
        multicellular organism development 5489
          system development 5038
            animal organ development 3855
              mesenchyme development 279
                mesenchymal cell differentiation 219
                  epithelial to mesenchymal transition 142
                    cardiac epithelial to mesenchymal transition 37
                      endocardial cushion to mesenchymal transition + 8
                      epithelial to mesenchymal transition involved in cardiac fibroblast development 2
                      epithelial to mesenchymal transition involved in coronary vasculature morphogenesis 0
                      epithelial to mesenchymal transition involved in endocardial cushion formation + 20
                      negative regulation of cardiac epithelial to mesenchymal transition + 2
                      positive regulation of cardiac epithelial to mesenchymal transition + 8
                      regulation of cardiac epithelial to mesenchymal transition + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.