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ONTOLOGY REPORT - ANNOTATIONS


Term:interferon-gamma-mediated signaling pathway
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Accession:GO:0060333 term browser browse the term
Definition:A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
Synonyms:exact_synonym: immune interferon signaling pathway;   interferon-gamma-mediated signalling pathway;   type II interferon-mediated signaling pathway
 related_synonym: type II IFN-mediated signaling pathway


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interferon-gamma-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma ISO (MGI:MGI:5490676|PMID:23629966)
(PMID:22504299), (PMID:23629966)
RGD PMID:22504299, PMID:23629966 MGI:MGI:5490676 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Irf1 interferon regulatory factor 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5317515|PMID:21909274)
Ensembl
UniProt
RGD
PMID:21909274 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5317515 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Jak2 Janus kinase 2 IDA PMID:11536325 BHF-UCL PMID:11536325 RGD:8553830 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Nmi N-myc (and STAT) interactor IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:37,458,891...37,480,984
Ensembl chr 3:37,458,890...37,480,984
JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO (MGI:MGI:5493216|PMID:12138178)
(PMID:21268089), (PMID:26479788)
RGD PMID:12138178, PMID:21268089, PMID:26479788 MGI:MGI:5493216 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tp53 tumor protein p53 ISO (MGI:MGI:5490676|PMID:23629966) RGD PMID:23629966 MGI:MGI:5490676 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
negative regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 ISO (PMID:16709924) RGD PMID:16709924 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 ISO (PMID:11679576) RGD PMID:11679576 NCBI chr10:11,059,701...11,085,186
Ensembl chr10:11,060,313...11,085,210
JBrowse link
G Otop1 otopetrin 1 ISS
ISO
GO_REF:0000024
(MGI:MGI:5750846|PMID:24379350)
UniProt
RGD
PMID:24379350 GO_REF:0000024, MGI:MGI:5750846 NCBI chr14:77,236,278...77,263,729
Ensembl chr14:77,236,278...77,263,729
JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 ISO (PMID:27796300)
(MGI:MGI:5905929|PMID:27796300)
RGD PMID:27796300 MGI:MGI:5905929 NCBI chr11:68,105,442...68,137,509
Ensembl chr11:68,105,369...68,137,535
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO (PMID:21268089) RGD PMID:21268089 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(MGI:MGI:5493216|PMID:12138178)
GO_REF:0000024
RGD
UniProt
PMID:12138178 GO_REF:0000024, MGI:MGI:5493216 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
positive regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpx hemopexin ISO MGI:MGI:2447193 (MGI:MGI:3807609|PMID:18641331) RGD PMID:18641331 MGI:MGI:3807609 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Irgm immunity-related GTPase M ISO (PMID:16888103)
(MGI:MGI:3656111|PMID:16888103)
RGD PMID:16888103 MGI:MGI:3656111 NCBI chr10:34,213,885...34,221,968
Ensembl chr10:34,213,936...34,221,928
JBrowse link
G Med1 mediator complex subunit 1 ISO MGI:MGI:2176946|MGI:MGI:3511276 (MGI:MGI:3798012|PMID:18339625) RGD PMID:18339625 MGI:MGI:3798012 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 ISO (PMID:20061403), (PMID:20639463) RGD PMID:20061403, PMID:20639463 NCBI chr19:10,904,381...11,006,202
Ensembl chr19:10,905,542...10,976,396
JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 ISO
IBA
(PMID:27796300)
PMID:21873635
(MGI:MGI:5905929|PMID:27796300)
RGD PMID:27796300, PMID:21873635 MGI:MGI:5905929, RGD:13792537 NCBI chr11:67,724,071...67,758,027
Ensembl chr11:67,724,076...67,756,799
JBrowse link
G Txk TXK tyrosine kinase ISO (PMID:11859127) RGD PMID:11859127 NCBI chr14:38,029,809...38,085,822
Ensembl chr14:38,030,189...38,085,919
JBrowse link
regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc37 cell division cycle 37, HSP90 cochaperone ISO
IEA
(PMID:16280321)
GO_REF:0000107
RGD
Ensembl
PMID:16280321 GO_REF:0000107 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO (PMID:16280321) RGD PMID:16280321 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Socs1 suppressor of cytokine signaling 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          cytokine-mediated signaling pathway 406
            interferon-gamma-mediated signaling pathway 21
              negative regulation of interferon-gamma-mediated signaling pathway 6
              positive regulation of interferon-gamma-mediated signaling pathway 6
              regulation of interferon-gamma-mediated signaling pathway + 15
Path 2
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to biotic stimulus 1743
        response to external biotic stimulus 1710
          response to other organism 1706
            defense response to other organism 1117
              innate immune response 835
                response to interferon-gamma 160
                  cellular response to interferon-gamma 129
                    interferon-gamma-mediated signaling pathway 21
                      negative regulation of interferon-gamma-mediated signaling pathway 6
                      positive regulation of interferon-gamma-mediated signaling pathway 6
                      regulation of interferon-gamma-mediated signaling pathway + 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.