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ONTOLOGY REPORT - ANNOTATIONS


Term:type I interferon signaling pathway
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Accession:GO:0060337 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: type I interferon-activated signaling pathway;   type I interferon-mediated signalling pathway
 related_synonym: type I interferon-mediated signaling pathway


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type I interferon signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFI27 interferon alpha inducible protein 27 ISO (PMID:27777077) UniProt PMID:27777077 NCBI chr14:74,742,775...74,748,820
Ensembl chr14:94,046,694...94,082,022
JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 ISO (MGI:MGI:5562515|PMID:23872679)
(MGI:MGI:5705226|PMID:14532120), (MGI:MGI:5792628|PMID:27129230)
(PMID:7665574)
UniProtKB
UniProt
PMID:7665574, PMID:14532120, PMID:23872679, PMID:27129230 MGI:MGI:5562515, MGI:MGI:5705226, MGI:MGI:5792628 NCBI chr21:19,683,496...19,719,034
Ensembl chr21:33,058,396...33,093,824
JBrowse link
G IFNAR2 interferon alpha and beta receptor subunit 2 ISO (PMID:26424569)
(PMID:7665574)
UniProtKB PMID:7665574, PMID:26424569 NCBI chr21:19,593,032...19,628,651 JBrowse link
G IFNB1 interferon beta 1 ISO (MGI:MGI:5792628|PMID:27129230)
(PMID:18035482)
UniProt
BHF-UCL
PMID:18035482, PMID:27129230 MGI:MGI:5792628 NCBI chr 9:20,884,742...20,886,317 JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chr  X:143,560,802...143,570,185
Ensembl chr  X:153,446,827...153,460,602
JBrowse link
G IRF3 interferon regulatory factor 3 ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chr19:46,674,193...46,680,464
Ensembl chr19:55,593,627...55,599,903
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chr 3:38,036,565...38,041,014
Ensembl chr 3:38,319,024...38,323,572
JBrowse link
G OAS2 2'-5'-oligoadenylate synthetase 2 ISO (MGI:MGI:6094812|PMID:29117179) UniProtKB PMID:29117179 MGI:MGI:6094812 NCBI chr12:110,583,668...110,616,727
Ensembl chr12:113,968,061...114,001,209
JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISO (MGI:MGI:5493216|PMID:12138178), (MGI:MGI:5619426|PMID:24598055)
(PMID:23386060)
CACAO
UniProtKB
PMID:12138178, PMID:23386060, PMID:24598055 MGI:MGI:5493216, MGI:MGI:5619426 NCBI chr2B:78,270,642...78,316,074
Ensembl chr2B:196,186,906...196,232,280
JBrowse link
G STAT2 signal transducer and activator of transcription 2 ISO (MGI:MGI:5619426|PMID:24598055)
(PMID:23391734)
CACAO
UniProtKB
PMID:23391734, PMID:24598055 MGI:MGI:5619426 NCBI chr12:32,555,523...32,574,137
Ensembl chr12:32,808,586...32,827,732
JBrowse link
G TREX1 three prime repair exonuclease 1 ISO (MGI:MGI:5908297|PMID:28351661) MGI PMID:28351661 MGI:MGI:5908297 NCBI chr 3:48,387,762...48,389,693
Ensembl chr 3:49,470,222...49,471,331
JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific ISO (MGI:MGI:3821394|PMID:19060901) MGI PMID:19060901 MGI:MGI:3821394 NCBI chr 1:129,937,993...129,983,747 JBrowse link
G CACTIN cactin, spliceosome C complex subunit ISO (PMID:20829348) UniProtKB PMID:20829348 NCBI chr19:2,636,129...2,652,332
Ensembl chr19:3,586,983...3,601,990
JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 ISO (PMID:23386060) UniProtKB PMID:23386060 NCBI chr 8:16,439,014...16,459,636
Ensembl chr 8:13,387,288...13,404,445
JBrowse link
G DCST1 DC-STAMP domain containing 1 ISO (PMID:27782195) UniProtKB PMID:27782195 NCBI chr 1:130,381,851...130,398,975
Ensembl chr 1:133,991,485...134,008,614
JBrowse link
G METTL3 methyltransferase like 3 ISO (PMID:30559377) UniProt PMID:30559377 NCBI chr14:2,315,868...2,329,460
Ensembl chr14:20,392,665...20,405,906
JBrowse link
G MMP12 matrix metallopeptidase 12 ISO (MGI:MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:MGI:5583923 NCBI chr11:97,809,644...97,822,063
Ensembl chr11:101,294,475...101,306,762
JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 ISO (PMID:23399697) UniProtKB PMID:23399697 NCBI chr 1:19,454,792...19,463,527
Ensembl chr 1:20,496,356...20,505,281
JBrowse link
G NLRC5 NLR family CARD domain containing 5 ISO (MGI:MGI:4454346|PMID:20434986)
(PMID:20434986)
UniProtKB PMID:20434986 MGI:MGI:4454346 NCBI chr16:37,267,541...37,361,369
Ensembl chr16:56,433,204...56,494,027
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 ISO (PMID:11909529)
(MGI:MGI:3691503|PMID:11909529), (MGI:MGI:5493216|PMID:12138178)
UniProtKB PMID:11909529, PMID:12138178 MGI:MGI:3691503, MGI:MGI:5493216 NCBI chr18:1,440,837...1,538,501
Ensembl chr18:16,562,052...16,659,570
JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 ISO (PMID:29670289)
(MGI:MGI:5521417|PMID:23972988)
UniProtKB PMID:23972988, PMID:29670289 MGI:MGI:5521417 NCBI chr20:33,224,200...33,282,018
Ensembl chr20:34,341,367...34,398,314
JBrowse link
G TREX1 three prime repair exonuclease 1 ISO (MGI:MGI:3834787|PMID:18724932) MGI PMID:18724932 MGI:MGI:3834787 NCBI chr 3:48,387,762...48,389,693
Ensembl chr 3:49,470,222...49,471,331
JBrowse link
G TTLL12 tubulin tyrosine ligase like 12 ISO (PMID:28011935) UniProt PMID:28011935 NCBI chr22:24,038,128...24,070,135
Ensembl chr22:42,249,660...42,271,318
JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein 2 ISO (PMID:30559377) UniProt PMID:30559377 NCBI chr 1:28,007,592...28,041,179
Ensembl chr 1:29,038,831...29,070,533
JBrowse link
G YTHDF3 YTH N6-methyladenosine RNA binding protein 3 ISO (MGI:MGI:6316470|PMID:30591559) UniProt PMID:30591559 MGI:MGI:6316470 NCBI chr 8:59,701,341...59,742,865
Ensembl chr 8:61,375,832...61,413,911
JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FADD Fas associated via death domain ISO (PMID:21109225) UniProtKB PMID:21109225 NCBI chr11:65,300,889...65,305,020 JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chr 1:182,070,565...182,096,797
Ensembl chr 1:186,351,807...186,377,971
JBrowse link
G IRF3 interferon regulatory factor 3 ISO (MGI:MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:MGI:3718275 NCBI chr19:46,674,193...46,680,464
Ensembl chr19:55,593,627...55,599,903
JBrowse link
G LSM14A LSM14A mRNA processing body assembly factor ISO (MGI:MGI:5432265|PMID:22745163) MGI PMID:22745163 MGI:MGI:5432265 NCBI chr19:31,099,211...31,159,930 JBrowse link
G MAVS mitochondrial antiviral signaling protein ISO (PMID:16127453), (PMID:20451243) BHF-UCL PMID:16127453, PMID:20451243 NCBI chr20:3,885,044...3,903,554
Ensembl chr20:3,659,559...3,701,089
JBrowse link
G MMP12 matrix metallopeptidase 12 ISO (MGI:MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:MGI:5583923 NCBI chr11:97,809,644...97,822,063
Ensembl chr11:101,294,475...101,306,762
JBrowse link
G NLRC5 NLR family CARD domain containing 5 ISO (PMID:20061403) UniProtKB PMID:20061403 NCBI chr16:37,267,541...37,361,369
Ensembl chr16:56,433,204...56,494,027
JBrowse link
G TBK1 TANK binding kinase 1 ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chr12:24,419,271...24,469,164
Ensembl chr12:24,917,246...24,968,587
JBrowse link
G TRIM6 tripartite motif containing 6 ISO (MGI:MGI:5645191|PMID:24882218)
(PMID:24882218)
UniProtKB PMID:24882218 MGI:MGI:5645191 NCBI chr11:5,731,256...5,748,057 JBrowse link
G UBE2K ubiquitin conjugating enzyme E2 K ISO (PMID:24882218) UniProtKB PMID:24882218 NCBI chr 4:34,026,942...34,111,923
Ensembl chr 4:39,877,966...39,960,397
JBrowse link
G WNT5A Wnt family member 5A ISO (PMID:19399181) BHF-UCL PMID:19399181 NCBI chr 3:55,396,279...55,418,579
Ensembl chr 3:56,621,380...56,638,051
JBrowse link
G ZBP1 Z-DNA binding protein 1 ISO (MGI:MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:MGI:3718275 NCBI chr20:53,944,224...53,961,362
Ensembl chr20:55,222,405...55,239,130
JBrowse link
regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC37 cell division cycle 37, HSP90 cochaperone ISO (PMID:16280321) MGI PMID:16280321 NCBI chr19:9,942,644...9,955,112
Ensembl chr19:10,606,246...10,618,702
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 ISO (PMID:16280321) MGI PMID:16280321 NCBI chr 6:43,842,796...43,849,637
Ensembl chr 6:45,125,773...45,133,872
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12564
    cellular process 11665
      signal transduction 3812
        cell surface receptor signaling pathway 2071
          cytokine-mediated signaling pathway 276
            type I interferon signaling pathway 35
              negative regulation of type I interferon-mediated signaling pathway + 14
              positive regulation of type I interferon-mediated signaling pathway 12
              regulation of type I interferon-mediated signaling pathway + 26
Path 2
Term Annotations click to browse term
  biological_process 12564
    response to stimulus 6737
      response to biotic stimulus 1230
        response to external biotic stimulus 1196
          response to other organism 1193
            defense response to other organism 691
              innate immune response 413
                response to type I interferon 42
                  cellular response to type I interferon 37
                    type I interferon signaling pathway 35
                      negative regulation of type I interferon-mediated signaling pathway + 14
                      positive regulation of type I interferon-mediated signaling pathway 12
                      regulation of type I interferon-mediated signaling pathway + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.