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ONTOLOGY REPORT - ANNOTATIONS


Term:type I interferon signaling pathway
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Accession:GO:0060337 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: type I interferon-activated signaling pathway;   type I interferon-mediated signalling pathway
 related_synonym: type I interferon-mediated signaling pathway


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type I interferon signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifnar1 interferon alpha and beta receptor subunit 1 ISO (PMID:7665574)
(MGI:MGI:5562515|PMID:23872679)
(MGI:MGI:5705226|PMID:14532120), (MGI:MGI:5792628|PMID:27129230)
UniProtKB
UniProt
PMID:7665574, PMID:14532120, PMID:23872679, PMID:27129230 MGI:MGI:5562515, MGI:MGI:5705226, MGI:MGI:5792628 NCBI chrNW_004955407:32,730,973...32,755,404
Ensembl chrNW_004955407:32,730,953...32,754,651
JBrowse link
G Ifnar2 interferon alpha and beta receptor subunit 2 ISO (PMID:26424569)
(PMID:7665574)
UniProtKB PMID:7665574, PMID:26424569 NCBI chrNW_004955407:32,601,862...32,637,852 JBrowse link
G Ifnb1 interferon beta 1 ISO (PMID:18035482)
(MGI:MGI:5792628|PMID:27129230)
BHF-UCL
UniProt
PMID:18035482, PMID:27129230 MGI:MGI:5792628 NCBI chrNW_004955434:23,301,623...23,302,304 JBrowse link
G Irak1 interleukin 1 receptor associated kinase 1 ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chrNW_004955580:663,651...668,622
Ensembl chrNW_004955580:661,609...668,622
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chrNW_004955559:1,223,986...1,228,671
Ensembl chrNW_004955559:1,224,874...1,228,624
JBrowse link
G Irf7 interferon regulatory factor 7 ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chrNW_004955476:11,442,781...11,445,706
Ensembl chrNW_004955476:11,443,272...11,445,657
JBrowse link
G Myd88 MYD88 innate immune signal transduction adaptor ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chrNW_004955427:25,553,589...25,557,654
Ensembl chrNW_004955427:25,553,589...25,559,138
JBrowse link
G Oas2 2'-5'-oligoadenylate synthetase 2 ISO (MGI:MGI:6094812|PMID:29117179) UniProtKB PMID:29117179 MGI:MGI:6094812 NCBI chrNW_004955482:9,365,400...9,386,314
Ensembl chrNW_004955482:9,364,516...9,386,852
JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO (MGI:MGI:5493216|PMID:12138178), (MGI:MGI:5619426|PMID:24598055)
(PMID:23386060)
CACAO
UniProtKB
PMID:12138178, PMID:23386060, PMID:24598055 MGI:MGI:5493216, MGI:MGI:5619426 NCBI chrNW_004955403:8,156,660...8,192,018
Ensembl chrNW_004955403:8,156,660...8,194,762
JBrowse link
G Stat2 signal transducer and activator of transcription 2 ISO (PMID:23391734)
(MGI:MGI:5619426|PMID:24598055)
UniProtKB
CACAO
PMID:23391734, PMID:24598055 MGI:MGI:5619426 NCBI chrNW_004955458:3,953,019...3,973,151
Ensembl chrNW_004955458:3,952,738...3,970,668
JBrowse link
G Trex1 three prime repair exonuclease 1 ISO (MGI:MGI:5908297|PMID:28351661) MGI PMID:28351661 MGI:MGI:5908297 NCBI chrNW_004955532:533,877...535,767
Ensembl chrNW_004955532:533,877...535,767
JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase RNA specific ISO (MGI:MGI:3821394|PMID:19060901) MGI PMID:19060901 MGI:MGI:3821394 NCBI chrNW_004955545:1,078,319...1,106,938
Ensembl chrNW_004955545:1,078,319...1,106,938
JBrowse link
G Cactin cactin, spliceosome C complex subunit ISO (PMID:20829348) UniProtKB PMID:20829348 NCBI chrNW_004955495:5,561,359...5,571,945
Ensembl chrNW_004955495:5,561,979...5,571,682
JBrowse link
G Cnot7 CCR4-NOT transcription complex subunit 7 ISO (PMID:23386060) UniProtKB PMID:23386060 NCBI chrNW_004955463:285,228...306,077
Ensembl chrNW_004955463:285,228...306,077
JBrowse link
G Dcst1 DC-STAMP domain containing 1 ISO (PMID:27782195) UniProtKB PMID:27782195 NCBI chrNW_004955545:1,529,926...1,545,459
Ensembl chrNW_004955545:1,530,062...1,545,139
JBrowse link
G Mettl3 methyltransferase like 3 ISO (PMID:30559377) UniProt PMID:30559377 NCBI chrNW_004955550:2,211,270...2,227,715
Ensembl chrNW_004955550:2,211,270...2,227,715
JBrowse link
G Mmp12 matrix metallopeptidase 12 ISO (MGI:MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:MGI:5583923 NCBI chrNW_004955412:6,045,146...6,057,112
Ensembl chrNW_004955412:6,045,100...6,057,262
JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 ISO (PMID:23399697) UniProtKB PMID:23399697 NCBI chrNW_004955452:1,059,168...1,066,096
Ensembl chrNW_004955452:1,058,930...1,066,096
JBrowse link
G Nlrc5 NLR family CARD domain containing 5 ISO (MGI:MGI:4454346|PMID:20434986)
(PMID:20434986)
UniProtKB PMID:20434986 MGI:MGI:4454346 NCBI chrNW_004955433:14,670,273...14,752,739
Ensembl chrNW_004955433:14,670,207...14,751,782
JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 ISO (MGI:MGI:3691503|PMID:11909529), (MGI:MGI:5493216|PMID:12138178)
(PMID:11909529)
UniProtKB PMID:11909529, PMID:12138178 MGI:MGI:3691503, MGI:MGI:5493216 NCBI chrNW_004955402:771,410...846,671 JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 ISO (PMID:29670289)
(MGI:MGI:5521417|PMID:23972988)
UniProtKB PMID:23972988, PMID:29670289 MGI:MGI:5521417 NCBI chrNW_004955422:24,714,103...24,780,672
Ensembl chrNW_004955422:24,735,161...24,778,830
JBrowse link
G Trex1 three prime repair exonuclease 1 ISO (MGI:MGI:3834787|PMID:18724932) MGI PMID:18724932 MGI:MGI:3834787 NCBI chrNW_004955532:533,877...535,767
Ensembl chrNW_004955532:533,877...535,767
JBrowse link
G Ttll12 tubulin tyrosine ligase like 12 ISO (PMID:28011935) UniProt PMID:28011935 NCBI chrNW_004955413:28,316,936...28,333,423
Ensembl chrNW_004955413:28,316,936...28,333,508
JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein 2 ISO (PMID:30559377) UniProt PMID:30559377 NCBI chrNW_004955452:7,783,398...7,815,468 JBrowse link
G Ythdf3 YTH N6-methyladenosine RNA binding protein 3 ISO (MGI:MGI:6316470|PMID:30591559) UniProt PMID:30591559 MGI:MGI:6316470 NCBI chrNW_004955444:15,758,596...15,789,979
Ensembl chrNW_004955444:15,758,596...15,789,979
JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain ISO (PMID:21109225) UniProtKB PMID:21109225 NCBI chrNW_004955422:16,026,323...16,035,808
Ensembl chrNW_004955422:16,031,280...16,036,281
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chrNW_004955406:42,056,014...42,077,701
Ensembl chrNW_004955406:42,056,014...42,077,701
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:MGI:3718275 NCBI chrNW_004955559:1,223,986...1,228,671
Ensembl chrNW_004955559:1,224,874...1,228,624
JBrowse link
G Irf7 interferon regulatory factor 7 ISO (MGI:MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:MGI:3718275 NCBI chrNW_004955476:11,442,781...11,445,706
Ensembl chrNW_004955476:11,443,272...11,445,657
JBrowse link
G Lsm14a LSM14A mRNA processing body assembly factor ISO (MGI:MGI:5432265|PMID:22745163) MGI PMID:22745163 MGI:MGI:5432265 NCBI chrNW_004955468:3,799,897...3,863,241 JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO (PMID:16127453), (PMID:20451243) BHF-UCL PMID:16127453, PMID:20451243 NCBI chrNW_004955415:14,691,918...14,704,782
Ensembl chrNW_004955415:14,695,438...14,703,672
JBrowse link
G Mmp12 matrix metallopeptidase 12 ISO (MGI:MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:MGI:5583923 NCBI chrNW_004955412:6,045,146...6,057,112
Ensembl chrNW_004955412:6,045,100...6,057,262
JBrowse link
G Nlrc5 NLR family CARD domain containing 5 ISO (PMID:20061403) UniProtKB PMID:20061403 NCBI chrNW_004955433:14,670,273...14,752,739
Ensembl chrNW_004955433:14,670,207...14,751,782
JBrowse link
G Tbk1 TANK binding kinase 1 ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chrNW_004955458:11,210,120...11,263,632
Ensembl chrNW_004955458:11,211,398...11,263,867
JBrowse link
G Trim6 tripartite motif containing 6 ISO (MGI:MGI:5645191|PMID:24882218)
(PMID:24882218)
UniProtKB PMID:24882218 MGI:MGI:5645191 NCBI chrNW_004955414:21,495,593...21,513,703
Ensembl chrNW_004955414:21,481,129...21,514,548
JBrowse link
G Ube2k ubiquitin conjugating enzyme E2 K ISO (PMID:24882218) UniProtKB PMID:24882218 NCBI chrNW_004955443:7,618,379...7,655,542
Ensembl chrNW_004955443:7,618,379...7,656,305
JBrowse link
G Wnt5a Wnt family member 5A ISO (PMID:19399181) BHF-UCL PMID:19399181 NCBI chrNW_004955430:5,304,817...5,325,684
Ensembl chrNW_004955430:5,304,745...5,325,684
JBrowse link
G Zbp1 Z-DNA binding protein 1 ISO (MGI:MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:MGI:3718275 NCBI chrNW_004955445:1,867,436...1,878,132
Ensembl chrNW_004955445:1,866,376...1,881,948
JBrowse link
regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc37 cell division cycle 37, HSP90 cochaperone ISO (PMID:16280321) MGI PMID:16280321 NCBI chrNW_004955495:1,642,467...1,651,288
Ensembl chrNW_004955495:1,641,236...1,651,288
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO (PMID:16280321) MGI PMID:16280321 NCBI chrNW_004955437:9,872,649...9,878,459
Ensembl chrNW_004955437:9,873,908...9,878,459
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11892
    cellular process 11094
      signal transduction 3676
        cell surface receptor signaling pathway 1993
          cytokine-mediated signaling pathway 263
            type I interferon signaling pathway 35
              negative regulation of type I interferon-mediated signaling pathway + 14
              positive regulation of type I interferon-mediated signaling pathway 13
              regulation of type I interferon-mediated signaling pathway + 27
Path 2
Term Annotations click to browse term
  biological_process 11892
    response to stimulus 6365
      response to biotic stimulus 1081
        response to external biotic stimulus 1047
          response to other organism 1044
            defense response to other organism 583
              innate immune response 355
                response to type I interferon 42
                  cellular response to type I interferon 36
                    type I interferon signaling pathway 35
                      negative regulation of type I interferon-mediated signaling pathway + 14
                      positive regulation of type I interferon-mediated signaling pathway 13
                      regulation of type I interferon-mediated signaling pathway + 27
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.