Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:type I interferon signaling pathway
go back to main search page
Accession:GO:0060337 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: type I interferon-activated signaling pathway;   type I interferon-mediated signalling pathway
 related_synonym: type I interferon-mediated signaling pathway


show annotations for term's descendants           Sort by:
 
type I interferon signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNAR2 interferon alpha and beta receptor subunit 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr31:27,860,094...27,891,361 JBrowse link
G IFNB1 interferon beta 1 IEA Ensembl GO_REF:0000107 NCBI chr11:40,668,295...40,668,855
Ensembl chr11:40,668,295...40,668,855
JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr  X:121,853,340...121,862,582
Ensembl chr  X:121,819,432...121,862,576
JBrowse link
G IRF3 interferon regulatory factor 3 ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chr 1:106,875,016...106,879,065
Ensembl chr 1:106,875,118...106,879,065
JBrowse link
G LOC475935 interferon-induced transmembrane protein 1-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:25,484,731...25,485,927 JBrowse link
G LOC483397 interferon-induced transmembrane protein 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:25,494,018...25,495,114 JBrowse link
G LOC487737 interferon alpha/beta receptor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr31:28,761,054...28,790,544 JBrowse link
G LOC609830 interferon alpha/beta receptor 1 ISO (MGI:MGI:5705226|PMID:14532120), (MGI:MGI:5792628|PMID:27129230)
(MGI:MGI:5562515|PMID:23872679)
(PMID:7665574)
UniProt
UniProtKB
PMID:7665574, PMID:14532120, PMID:23872679, PMID:27129230 MGI:MGI:5562515, MGI:MGI:5705226, MGI:MGI:5792628 NCBI chr31:28,854,765...28,876,399 JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor IEA Ensembl GO_REF:0000107 NCBI chr23:7,901,578...7,905,274
Ensembl chr23:7,901,250...7,904,534
JBrowse link
G OAS2 2'-5'-oligoadenylate synthetase 2 IEA Ensembl GO_REF:0000107 NCBI chr26:10,431,881...10,450,085
Ensembl chr26:10,432,042...10,449,009
JBrowse link
G STAT1 signal transducer and activator of transcription 1 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr37:1,513,438...1,549,837
Ensembl chr37:1,507,219...1,550,178
JBrowse link
G STAT2 signal transducer and activator of transcription 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:641,543...660,882
Ensembl chr10:642,718...658,546
JBrowse link
G TREX1 three prime repair exonuclease 1 IEA Ensembl GO_REF:0000107 NCBI chr20:40,624,845...40,626,840
Ensembl chr20:40,624,891...40,626,906
JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific IEA Ensembl GO_REF:0000107 NCBI chr 7:42,762,021...42,785,192
Ensembl chr 7:42,748,136...42,782,999
JBrowse link
G CACTIN cactin, spliceosome C complex subunit IEA Ensembl GO_REF:0000107 NCBI chr20:55,803,494...55,817,467
Ensembl chr20:55,803,530...55,816,549
JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 IEA Ensembl GO_REF:0000107 NCBI chr16:40,554,214...40,571,841
Ensembl chr16:40,555,565...40,571,720
JBrowse link
G DCST1 DC-STAMP domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:42,443,787...42,457,361
Ensembl chr 7:42,428,113...42,457,062
JBrowse link
G METTL3 methyltransferase like 3 IEA Ensembl GO_REF:0000107 NCBI chr15:18,528,755...18,546,303
Ensembl chr15:18,528,772...18,546,531
JBrowse link
G MMP12 matrix metallopeptidase 12 IEA Ensembl GO_REF:0000107 NCBI chr 5:28,918,626...28,933,404
Ensembl chr 5:28,918,594...28,933,309
JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:78,394,013...78,402,032
Ensembl chr 2:78,394,040...78,425,482
JBrowse link
G NLRC5 NLR family CARD domain containing 5 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 2:59,279,535...59,359,327
Ensembl chr 2:59,280,390...59,338,931
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719
JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 IEA Ensembl GO_REF:0000107 NCBI chr24:25,623,997...25,676,336
Ensembl chr24:25,626,134...25,680,902
JBrowse link
G TREX1 three prime repair exonuclease 1 IEA Ensembl GO_REF:0000107 NCBI chr20:40,624,845...40,626,840
Ensembl chr20:40,624,891...40,626,906
JBrowse link
G TTLL12 tubulin tyrosine ligase like 12 IEA Ensembl GO_REF:0000107 NCBI chr10:22,367,590...22,385,167
Ensembl chr10:22,367,367...22,386,617
JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein 2 IEA Ensembl GO_REF:0000107 NCBI chr 2:71,760,232...71,791,420
Ensembl chr 2:71,760,312...71,792,527
JBrowse link
G YTHDF3 YTH N6-methyladenosine RNA binding protein 3 IEA Ensembl GO_REF:0000107 NCBI chr29:13,239,900...13,280,035
Ensembl chr29:13,239,966...13,277,051
JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FADD Fas associated via death domain ISO (PMID:21109225) UniProtKB PMID:21109225 NCBI chr18:48,087,447...48,094,497 JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon IEA Ensembl GO_REF:0000107 NCBI chr38:2,747,303...2,772,574
Ensembl chr38:2,747,297...2,772,587
JBrowse link
G IRF3 interferon regulatory factor 3 ISO (MGI:MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:MGI:3718275 NCBI chr 1:106,875,016...106,879,065
Ensembl chr 1:106,875,118...106,879,065
JBrowse link
G LSM14A LSM14A mRNA processing body assembly factor IEA Ensembl GO_REF:0000107 NCBI chr 1:118,061,854...118,117,493
Ensembl chr 1:118,063,512...118,117,478
JBrowse link
G MAVS mitochondrial antiviral signaling protein IEA Ensembl GO_REF:0000107 NCBI chr24:17,510,209...17,529,286
Ensembl chr24:17,512,761...17,523,807
JBrowse link
G MMP12 matrix metallopeptidase 12 IEA Ensembl GO_REF:0000107 NCBI chr 5:28,918,626...28,933,404
Ensembl chr 5:28,918,594...28,933,309
JBrowse link
G NLRC5 NLR family CARD domain containing 5 IEA Ensembl GO_REF:0000107 NCBI chr 2:59,279,535...59,359,327
Ensembl chr 2:59,280,390...59,338,931
JBrowse link
G TBK1 TANK binding kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr10:7,169,664...7,208,890
Ensembl chr10:7,168,007...7,208,899
JBrowse link
G TRIM6 tripartite motif containing 6 IEA Ensembl GO_REF:0000107 NCBI chr21:28,595,887...28,611,562
Ensembl chr21:28,595,448...28,611,124
JBrowse link
G UBE2K ubiquitin conjugating enzyme E2 K IEA Ensembl GO_REF:0000107 NCBI chr 3:72,713,035...72,780,199
Ensembl chr 3:72,717,236...72,780,210
JBrowse link
G WNT5A Wnt family member 5A ISS UniProtKB GO_REF:0000024 NCBI chr20:34,756,430...34,790,937
Ensembl chr20:34,769,930...34,786,673
JBrowse link
G ZBP1 Z-DNA binding protein 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr24:42,583,674...42,589,857
Ensembl chr24:42,584,083...42,589,753
JBrowse link
regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC37 cell division cycle 37, HSP90 cochaperone IEA Ensembl GO_REF:0000107 NCBI chr20:50,727,702...50,738,197
Ensembl chr20:50,727,749...50,736,269
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 IEA Ensembl GO_REF:0000107 NCBI chr12:12,658,415...12,664,945
Ensembl chr12:12,660,008...12,664,940
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16187
    cellular process 15465
      signal transduction 5456
        cell surface receptor signaling pathway 2472
          cytokine-mediated signaling pathway 385
            type I interferon signaling pathway 37
              negative regulation of type I interferon-mediated signaling pathway + 14
              positive regulation of type I interferon-mediated signaling pathway 12
              regulation of type I interferon-mediated signaling pathway + 26
Path 2
Term Annotations click to browse term
  biological_process 16187
    response to stimulus 8559
      response to biotic stimulus 1419
        response to external biotic stimulus 1386
          response to other organism 1382
            defense response to other organism 815
              innate immune response 553
                response to type I interferon 47
                  cellular response to type I interferon 41
                    type I interferon signaling pathway 37
                      negative regulation of type I interferon-mediated signaling pathway + 14
                      positive regulation of type I interferon-mediated signaling pathway 12
                      regulation of type I interferon-mediated signaling pathway + 26
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.