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ONTOLOGY REPORT - ANNOTATIONS


Term:type I interferon signaling pathway
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Accession:GO:0060337 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: type I interferon-activated signaling pathway;   type I interferon-mediated signalling pathway
 related_synonym: type I interferon-mediated signaling pathway


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type I interferon signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifi27 interferon, alpha-inducible protein 27 ISO (PMID:27777077) UniProt PMID:27777077 NCBI chr12:103,434,189...103,440,245
Ensembl chr12:103,434,211...103,440,239
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 7:140,967,429...140,969,827
Ensembl chr 7:140,967,221...140,969,825
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 7:140,954,837...140,959,686
Ensembl chr 7:140,954,837...140,955,987
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 IDA
IBA
(MGI:MGI:4431293|PMID:20064371)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:20064371, PMID:21873635 MGI:MGI:4431293, MGI:MGI:6201960 NCBI chr 7:141,009,590...141,010,744
Ensembl chr 7:141,009,586...141,010,770
JBrowse link
G Ifitm6 interferon induced transmembrane protein 6 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 7:141,015,812...141,016,892
Ensembl chr 7:141,015,699...141,017,924
JBrowse link
G Ifitm7 interferon induced transmembrane protein 7 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr16:13,981,702...13,986,867
Ensembl chr16:13,981,699...13,986,888
JBrowse link
G Ifna1 interferon alpha 1 IDA (MGI:MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:MGI:5583923 NCBI chr 4:88,850,087...88,850,656
Ensembl chr 4:88,850,087...88,850,656
JBrowse link
G Ifnar1 interferon (alpha and beta) receptor 1 IDA
IMP
ISO
(MGI:MGI:5562515|PMID:23872679)
(MGI:MGI:5705226|PMID:14532120), (MGI:MGI:5792628|PMID:27129230)
UniProtKB
UniProt
MGI
PMID:14532120, PMID:23872679, PMID:27129230 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5562515, MGI:MGI:5705226, MGI:MGI:5792628 NCBI chr16:91,485,032...91,510,523
Ensembl chr16:91,485,238...91,507,441
JBrowse link
G Ifnar2 interferon (alpha and beta) receptor 2 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr16:91,372,783...91,405,589
Ensembl chr16:91,372,783...91,405,589
JBrowse link
G Ifnb1 interferon beta 1, fibroblast ISO
IMP
(MGI:MGI:5792628|PMID:27129230) MGI
UniProt
PMID:27129230 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5792628 NCBI chr 4:88,522,025...88,522,794
Ensembl chr 4:88,522,025...88,522,774
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr  X:74,013,914...74,023,921
Ensembl chr  X:74,013,914...74,023,918
JBrowse link
G Irf3 interferon regulatory factor 3 IMP (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chr 7:44,997,648...45,002,848
Ensembl chr 7:44,997,648...45,002,848
JBrowse link
G Irf7 interferon regulatory factor 7 IMP (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chr 7:141,263,183...141,266,499
Ensembl chr 7:141,262,706...141,266,481
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:119,335,934...119,340,018
Ensembl chr 9:119,335,934...119,341,411
JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 IDA (MGI:MGI:6094812|PMID:29117179) UniProtKB PMID:29117179 MGI:MGI:6094812 NCBI chr 5:120,730,333...120,749,886
Ensembl chr 5:120,730,333...120,749,853
JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO
IBA
IMP
(MGI:MGI:6201960|PMID:21873635)
(MGI:MGI:5493216|PMID:12138178), (MGI:MGI:5619426|PMID:24598055)
MGI
GO_Central
CACAO
PMID:12138178, PMID:21873635, PMID:24598055 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5493216, MGI:MGI:5619426, MGI:MGI:6201960 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865
JBrowse link
G Stat2 signal transducer and activator of transcription 2 IMP
IBA
ISO
(MGI:MGI:5619426|PMID:24598055)
(MGI:MGI:6201960|PMID:21873635)
CACAO
GO_Central
MGI
PMID:21873635, PMID:24598055 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5619426, MGI:MGI:6201960 NCBI chr10:128,270,498...128,292,853
Ensembl chr10:128,270,559...128,292,849
JBrowse link
G Trex1 three prime repair exonuclease 1 IMP (MGI:MGI:5908297|PMID:28351661) MGI PMID:28351661 MGI:MGI:5908297 NCBI chr 9:109,057,932...109,059,723
Ensembl chr 9:109,057,933...109,059,734
JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific IMP (MGI:MGI:3821394|PMID:19060901) MGI PMID:19060901 MGI:MGI:3821394 NCBI chr 3:89,714,469...89,753,455
Ensembl chr 3:89,715,022...89,753,446
JBrowse link
G Cactin cactin, spliceosome C complex subunit ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:81,321,103...81,326,251
Ensembl chr10:81,321,103...81,326,242
JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 8:40,492,538...40,515,847
Ensembl chr 8:40,492,540...40,515,847
JBrowse link
G Dcst1 DC-STAMP domain containing 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 3:89,350,219...89,365,253
Ensembl chr 3:89,350,219...89,365,253
JBrowse link
G Mettl3 methyltransferase like 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr14:52,294,841...52,308,741
Ensembl chr14:52,294,841...52,305,128
JBrowse link
G Mmp12 matrix metallopeptidase 12 IMP (MGI:MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:MGI:5583923 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
JBrowse link
G Mul1 mitochondrial ubiquitin ligase activator of NFKB 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:138,434,660...138,442,265
Ensembl chr 4:138,434,671...138,442,265
JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 IDA
IBA
ISO
(MGI:MGI:4454346|PMID:20434986)
(MGI:MGI:6201960|PMID:21873635)
UniProtKB
GO_Central
MGI
PMID:20434986, PMID:21873635 GO_REF:0000096, MGI:MGI:4454346, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 8:94,434,335...94,527,272
Ensembl chr 8:94,434,356...94,527,272
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
IMP
(MGI:MGI:3691503|PMID:11909529), (MGI:MGI:5493216|PMID:12138178) MGI
UniProtKB
PMID:11909529, PMID:12138178 GO_REF:0000096, MGI:MGI:3691503, MGI:MGI:4834177, MGI:MGI:5493216 NCBI chr18:67,665,501...67,724,632
Ensembl chr18:67,665,511...67,724,595
JBrowse link
G Samhd1 SAM domain and HD domain, 1 IMP
ISO
(MGI:MGI:5521417|PMID:23972988) UniProtKB
MGI
PMID:23972988 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5521417 NCBI chr 2:157,097,534...157,135,096
Ensembl chr 2:157,097,533...157,135,265
JBrowse link
G Trex1 three prime repair exonuclease 1 IMP (MGI:MGI:3834787|PMID:18724932) MGI PMID:18724932 MGI:MGI:3834787 NCBI chr 9:109,057,932...109,059,723
Ensembl chr 9:109,057,933...109,059,734
JBrowse link
G Ttll12 tubulin tyrosine ligase-like family, member 12 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr15:83,575,094...83,595,157
Ensembl chr15:83,575,090...83,595,157
JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:132,184,916...132,212,256
Ensembl chr 4:132,184,912...132,212,303
JBrowse link
G Ythdf3 YTH N6-methyladenosine RNA binding protein 3 IMP (MGI:MGI:6316470|PMID:30591559) UniProt PMID:30591559 MGI:MGI:6316470 NCBI chr 3:16,183,148...16,217,037
Ensembl chr 3:16,183,212...16,217,037
JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas (TNFRSF6)-associated via death domain ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:144,578,323...144,582,441
Ensembl chr 7:144,577,318...144,582,463
JBrowse link
G Ikbke inhibitor of kappaB kinase epsilon IMP (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chr 1:131,254,600...131,279,601
Ensembl chr 1:131,254,343...131,279,606
JBrowse link
G Irf3 interferon regulatory factor 3 IMP (MGI:MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:MGI:3718275 NCBI chr 7:44,997,648...45,002,848
Ensembl chr 7:44,997,648...45,002,848
JBrowse link
G Irf7 interferon regulatory factor 7 IMP (MGI:MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:MGI:3718275 NCBI chr 7:141,263,183...141,266,499
Ensembl chr 7:141,262,706...141,266,481
JBrowse link
G Lsm14a LSM14A mRNA processing body assembly factor IDA (MGI:MGI:5432265|PMID:22745163) MGI PMID:22745163 MGI:MGI:5432265 NCBI chr 7:34,344,144...34,390,026
Ensembl chr 7:34,344,646...34,393,315
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:131,234,063...131,248,025
Ensembl chr 2:131,234,063...131,248,025
JBrowse link
G Mmp12 matrix metallopeptidase 12 IMP (MGI:MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:MGI:5583923 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 8:94,434,335...94,527,272
Ensembl chr 8:94,434,356...94,527,272
JBrowse link
G Tbk1 TANK-binding kinase 1 IMP (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chr10:121,546,455...121,586,794
Ensembl chr10:121,546,455...121,586,787
JBrowse link
G Trim6 tripartite motif-containing 6 IMP
ISO
(MGI:MGI:5645191|PMID:24882218) UniProtKB
MGI
PMID:24882218 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5645191 NCBI chr 7:104,218,795...104,235,152
Ensembl chr 7:104,218,793...104,235,152
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 5:65,537,245...65,598,989
Ensembl chr 5:65,537,233...65,598,988
JBrowse link
G Wnt5a wingless-type MMTV integration site family, member 5A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr14:28,504,543...28,527,448
Ensembl chr14:28,504,750...28,527,448
JBrowse link
G Zbp1 Z-DNA binding protein 1 IMP
IBA
(MGI:MGI:3718275|PMID:17618271)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:17618271, PMID:21873635 MGI:MGI:3718275, MGI:MGI:6201960 NCBI chr 2:173,206,612...173,218,959
Ensembl chr 2:173,206,612...173,218,923
JBrowse link
regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc37 cell division cycle 37 ISO (MGI:MGI:3621255|PMID:16280321) MGI PMID:16280321 MGI:MGI:3621255 NCBI chr 9:21,139,431...21,149,934
Ensembl chr 9:21,133,222...21,149,982
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 ISO (PMID:16280321) MGI PMID:16280321 NCBI chr17:45,567,778...45,573,261
Ensembl chr17:45,567,775...45,573,271
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23386
    cellular process 17413
      signal transduction 6323
        cell surface receptor signaling pathway 2730
          cytokine-mediated signaling pathway 391
            type I interferon signaling pathway 42
              negative regulation of type I interferon-mediated signaling pathway + 14
              positive regulation of type I interferon-mediated signaling pathway 13
              regulation of type I interferon-mediated signaling pathway + 27
Path 2
Term Annotations click to browse term
  biological_process 23386
    response to stimulus 10301
      response to biotic stimulus 1871
        response to external biotic stimulus 1838
          response to other organism 1835
            defense response to other organism 1196
              innate immune response 917
                response to type I interferon 50
                  cellular response to type I interferon 44
                    type I interferon signaling pathway 42
                      negative regulation of type I interferon-mediated signaling pathway + 14
                      positive regulation of type I interferon-mediated signaling pathway 13
                      regulation of type I interferon-mediated signaling pathway + 27
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.