Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:type I interferon signaling pathway
go back to main search page
Accession:GO:0060337 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: type I interferon-activated signaling pathway;   type I interferon-mediated signalling pathway
 related_synonym: type I interferon-mediated signaling pathway


show annotations for term's descendants           Sort by:
 
type I interferon signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFITM1 interferon-induced transmembrane protein 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:124,095...125,495 JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr13:196,925,731...196,951,398
Ensembl chr13:196,925,704...196,952,239
JBrowse link
G IFNAR2 interferon alpha and beta receptor subunit 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:196,765,915...196,852,640 JBrowse link
G IFNB1 interferon beta 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr  X:124,717,604...124,724,855
Ensembl chr  X:124,717,612...124,724,860
JBrowse link
G IRF3 interferon regulatory factor 3 IEA Ensembl GO_REF:0000107 NCBI chr 6:54,701,733...54,706,079
Ensembl chr 6:54,701,668...54,707,151
JBrowse link
G IRF7 interferon regulatory factor 7 IEA Ensembl GO_REF:0000107 NCBI chr 2:372,235...375,572
Ensembl chr 2:371,606...375,381
JBrowse link
G LOC100626247 interferon-induced transmembrane protein 1-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:133,896...135,271 JBrowse link
G LOC102161418 interferon-induced transmembrane protein 1-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:156,364...157,650 JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor IEA Ensembl GO_REF:0000107 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,964,071...22,983,109
JBrowse link
G OAS2 2'-5'-oligoadenylate synthetase 2 IEA Ensembl GO_REF:0000107 NCBI chr14:38,827,667...38,847,697
Ensembl chr14:38,827,660...38,860,820
JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISS
IEA
IBA
(PMID:21873635) UniProt
Ensembl
GO_Central
PMID:21873635 GO_REF:0000024, GO_REF:0000107 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260
JBrowse link
G STAT2 signal transducer and activator of transcription 2 ISS
IEA
IBA
(PMID:21873635) UniProt
Ensembl
GO_Central
PMID:21873635 GO_REF:0000024, GO_REF:0000107 NCBI chr 5:21,733,030...21,748,960
Ensembl chr 5:21,733,035...21,751,354
JBrowse link
G TREX1 three prime repair exonuclease 1 IEA Ensembl GO_REF:0000107 NCBI chr13:31,177,604...31,180,764
Ensembl chr13:31,178,601...31,180,592
JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific IEA Ensembl GO_REF:0000107 NCBI chr 4:95,154,230...95,197,308
Ensembl chr 4:95,154,358...95,197,305
JBrowse link
G CACTIN cactin, spliceosome C complex subunit IEA Ensembl GO_REF:0000107 NCBI chr 2:75,049,250...75,065,990
Ensembl chr 2:75,049,261...75,065,300
JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 IEA Ensembl GO_REF:0000107 NCBI chr17:4,934,379...4,950,093
Ensembl chr17:4,933,453...4,950,346
JBrowse link
G DCST1 DC-STAMP domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr 4:94,748,430...94,768,322
Ensembl chr 4:94,748,214...94,768,432
JBrowse link
G METTL3 methyltransferase like 3 IEA Ensembl GO_REF:0000107 NCBI chr 7:77,661,945...77,679,459
Ensembl chr 7:77,662,058...77,695,948
JBrowse link
G MMP12 matrix metallopeptidase 12 IEA Ensembl GO_REF:0000107 NCBI chr 9:33,473,625...33,483,630
Ensembl chr 9:33,473,085...33,483,679
JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:78,747,687...78,758,821
Ensembl chr 6:78,747,649...78,758,813
JBrowse link
G NLRC5 NLR family CARD domain containing 5 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 6:18,933,179...19,036,288
Ensembl chr 6:18,937,665...19,036,820
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,251...96,847,133
JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 IEA Ensembl GO_REF:0000107 NCBI chr17:40,117,348...40,171,935
Ensembl chr17:40,112,978...40,171,895
JBrowse link
G TREX1 three prime repair exonuclease 1 IEA Ensembl GO_REF:0000107 NCBI chr13:31,177,604...31,180,764
Ensembl chr13:31,178,601...31,180,592
JBrowse link
G TTLL12 tubulin tyrosine ligase like 12 IEA Ensembl GO_REF:0000107 NCBI chr 5:5,687,895...5,719,003
Ensembl chr 5:5,701,583...5,720,724
JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:85,717,147...85,756,750
Ensembl chr 6:85,716,917...85,751,583
JBrowse link
G YTHDF3 YTH N6-methyladenosine RNA binding protein 3 IEA Ensembl GO_REF:0000107 NCBI chr 4:70,887,101...70,928,839
Ensembl chr 4:70,887,103...70,928,808
JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FADD Fas associated via death domain IEA Ensembl GO_REF:0000107 NCBI chr 2:3,191,718...3,194,820
Ensembl chr 2:3,186,744...3,194,792
JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon IEA Ensembl GO_REF:0000107 NCBI chr 9:67,123,055...67,147,991
Ensembl chr 9:67,123,265...67,147,992
JBrowse link
G IRF3 interferon regulatory factor 3 IEA Ensembl GO_REF:0000107 NCBI chr 6:54,701,733...54,706,079
Ensembl chr 6:54,701,668...54,707,151
JBrowse link
G IRF7 interferon regulatory factor 7 IEA Ensembl GO_REF:0000107 NCBI chr 2:372,235...375,572
Ensembl chr 2:371,606...375,381
JBrowse link
G LOC100622028 tripartite motif-containing protein 6 IEA Ensembl GO_REF:0000107 NCBI chr 9:4,197,922...4,204,688
Ensembl chr 9:4,197,922...4,204,664
JBrowse link
G LSM14A LSM14A mRNA processing body assembly factor IEA Ensembl GO_REF:0000107 NCBI chr 6:43,847,882...43,901,697
Ensembl chr 6:43,847,700...43,903,604
JBrowse link
G MAVS mitochondrial antiviral signaling protein IEA Ensembl GO_REF:0000107 NCBI chr17:31,850,646...31,869,273
Ensembl chr17:31,850,155...31,869,187
JBrowse link
G MMP12 matrix metallopeptidase 12 IEA Ensembl GO_REF:0000107 NCBI chr 9:33,473,625...33,483,630
Ensembl chr 9:33,473,085...33,483,679
JBrowse link
G NLRC5 NLR family CARD domain containing 5 IEA Ensembl GO_REF:0000107 NCBI chr 6:18,933,179...19,036,288
Ensembl chr 6:18,937,665...19,036,820
JBrowse link
G TBK1 TANK binding kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:28,880,210...28,929,964
Ensembl chr 5:28,828,568...28,929,964
JBrowse link
G UBE2K ubiquitin conjugating enzyme E2 K IEA Ensembl GO_REF:0000107 NCBI chr 8:30,887,784...30,961,685
Ensembl chr 8:30,887,829...30,963,762
JBrowse link
G WNT5A Wnt family member 5A IEA Ensembl GO_REF:0000107 NCBI chr13:37,344,684...37,367,215
Ensembl chr13:37,344,699...37,367,207
JBrowse link
G ZBP1 Z-DNA binding protein 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:57,975,982...57,986,117
Ensembl chr17:57,973,096...57,986,136
JBrowse link
regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC37 cell division cycle 37, HSP90 cochaperone IEA Ensembl GO_REF:0000107 NCBI chr 2:69,202,695...69,212,909
Ensembl chr 2:69,201,579...69,225,994
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:39,237,299...39,250,479
Ensembl chr 7:39,244,458...39,254,002
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    cellular process 15775
      signal transduction 5925
        cell surface receptor signaling pathway 2486
          cytokine-mediated signaling pathway 391
            type I interferon signaling pathway 38
              negative regulation of type I interferon-mediated signaling pathway + 14
              positive regulation of type I interferon-mediated signaling pathway 13
              regulation of type I interferon-mediated signaling pathway + 27
Path 2
Term Annotations click to browse term
  biological_process 16545
    response to stimulus 8984
      response to biotic stimulus 1418
        response to external biotic stimulus 1384
          response to other organism 1380
            defense response to other organism 833
              innate immune response 555
                response to type I interferon 48
                  cellular response to type I interferon 42
                    type I interferon signaling pathway 38
                      negative regulation of type I interferon-mediated signaling pathway + 14
                      positive regulation of type I interferon-mediated signaling pathway 13
                      regulation of type I interferon-mediated signaling pathway + 27
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.