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ONTOLOGY REPORT - ANNOTATIONS


Term:type I interferon signaling pathway
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Accession:GO:0060337 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: type I interferon-activated signaling pathway;   type I interferon-mediated signalling pathway
 related_synonym: type I interferon-mediated signaling pathway


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type I interferon signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifnar1 interferon alpha and beta receptor subunit 1 ISO (MGI:MGI:5705226|PMID:14532120), (MGI:MGI:5792628|PMID:27129230)
(PMID:7665574)
(MGI:MGI:5562515|PMID:23872679)
UniProt
UniProtKB
PMID:7665574, PMID:14532120, PMID:23872679, PMID:27129230 MGI:MGI:5562515, MGI:MGI:5705226, MGI:MGI:5792628 NCBI chrNW_004936500:8,953,809...8,975,261 JBrowse link
G Ifnar2 interferon alpha and beta receptor subunit 2 ISO (PMID:26424569)
(PMID:7665574)
UniProtKB PMID:7665574, PMID:26424569 NCBI chrNW_004936500:9,060,975...9,091,618 JBrowse link
G Irak1 interleukin 1 receptor associated kinase 1 ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chrNW_004936809:891,407...900,311 JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chrNW_004936664:3,477,750...3,482,489 JBrowse link
G Irf7 interferon regulatory factor 7 ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chrNW_004936888:445,340...448,801 JBrowse link
G LOC101968765 interferon beta ISO (MGI:MGI:5792628|PMID:27129230)
(PMID:18035482)
UniProt
BHF-UCL
PMID:18035482, PMID:27129230 MGI:MGI:5792628 NCBI chrNW_004936652:2,736,270...2,736,833 JBrowse link
G Myd88 MYD88 innate immune signal transduction adaptor ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chrNW_004936473:27,672,237...27,676,339 JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO (MGI:MGI:5493216|PMID:12138178), (MGI:MGI:5619426|PMID:24598055)
(PMID:23386060)
CACAO
UniProtKB
PMID:12138178, PMID:23386060, PMID:24598055 MGI:MGI:5493216, MGI:MGI:5619426 NCBI chrNW_004936506:7,196,860...7,235,854 JBrowse link
G Stat2 signal transducer and activator of transcription 2 ISO (MGI:MGI:5619426|PMID:24598055)
(PMID:23391734)
CACAO
UniProtKB
PMID:23391734, PMID:24598055 MGI:MGI:5619426 NCBI chrNW_004936646:747,178...763,449 JBrowse link
G Trex1 three prime repair exonuclease 1 ISO (MGI:MGI:5908297|PMID:28351661) MGI PMID:28351661 MGI:MGI:5908297 NCBI chrNW_004936529:264,535...266,451 JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase RNA specific ISO (MGI:MGI:3821394|PMID:19060901) MGI PMID:19060901 MGI:MGI:3821394 NCBI chrNW_004936580:4,183,016...4,208,341 JBrowse link
G Cactin cactin, spliceosome C complex subunit ISO (PMID:20829348) UniProtKB PMID:20829348 NCBI chrNW_004936588:2,051,636...2,061,651 JBrowse link
G Cnot7 CCR4-NOT transcription complex subunit 7 ISO (PMID:23386060) UniProtKB PMID:23386060 NCBI chrNW_004936573:6,288,397...6,305,984 JBrowse link
G Dcst1 DC-STAMP domain containing 1 ISO (PMID:27782195) UniProtKB PMID:27782195 NCBI chrNW_004936580:4,571,349...4,586,459 JBrowse link
G Mettl3 methyltransferase like 3 ISO (PMID:30559377) UniProt PMID:30559377 NCBI chrNW_004936880:646,835...661,312 JBrowse link
G Mmp12 matrix metallopeptidase 12 ISO (MGI:MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:MGI:5583923 NCBI chrNW_004936551:5,107,567...5,117,843 JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 ISO (PMID:23399697) UniProtKB PMID:23399697 NCBI chrNW_004936474:6,479,640...6,486,080 JBrowse link
G Nlrc5 NLR family CARD domain containing 5 ISO (PMID:20434986)
(MGI:MGI:4454346|PMID:20434986)
UniProtKB PMID:20434986 MGI:MGI:4454346 NCBI chrNW_004936475:9,137,929...9,218,682 JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 ISO (PMID:11909529)
(MGI:MGI:3691503|PMID:11909529), (MGI:MGI:5493216|PMID:12138178)
UniProtKB PMID:11909529, PMID:12138178 MGI:MGI:3691503, MGI:MGI:5493216 NCBI chrNW_004936626:2,390,004...2,472,039 JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 ISO (PMID:29670289)
(MGI:MGI:5521417|PMID:23972988)
UniProtKB PMID:23972988, PMID:29670289 MGI:MGI:5521417 NCBI chrNW_004936561:4,180,607...4,238,623 JBrowse link
G Trex1 three prime repair exonuclease 1 ISO (MGI:MGI:3834787|PMID:18724932) MGI PMID:18724932 MGI:MGI:3834787 NCBI chrNW_004936529:264,535...266,451 JBrowse link
G Ttll12 tubulin tyrosine ligase like 12 ISO (PMID:28011935) UniProt PMID:28011935 NCBI chrNW_004936718:996,758...1,013,372 JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein 2 ISO (PMID:30559377) UniProt PMID:30559377 NCBI chrNW_004936474:12,791,121...12,827,122 JBrowse link
G Ythdf3 YTH N6-methyladenosine RNA binding protein 3 ISO (MGI:MGI:6316470|PMID:30591559) UniProt PMID:30591559 MGI:MGI:6316470 NCBI chrNW_004936496:10,323,338...10,362,150 JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain ISO (PMID:21109225) UniProtKB PMID:21109225 NCBI chrNW_004936599:633,501...639,412 JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chrNW_004936557:6,066,207...6,090,767 JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:MGI:3718275 NCBI chrNW_004936664:3,477,750...3,482,489 JBrowse link
G Irf7 interferon regulatory factor 7 ISO (MGI:MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:MGI:3718275 NCBI chrNW_004936888:445,340...448,801 JBrowse link
G Lsm14a LSM14A mRNA processing body assembly factor ISO (MGI:MGI:5432265|PMID:22745163) MGI PMID:22745163 MGI:MGI:5432265 NCBI chrNW_004936570:1,723,966...1,791,784 JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO (PMID:16127453), (PMID:20451243) BHF-UCL PMID:16127453, PMID:20451243 NCBI chrNW_004936485:14,842,778...14,859,163 JBrowse link
G Mmp12 matrix metallopeptidase 12 ISO (MGI:MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:MGI:5583923 NCBI chrNW_004936551:5,107,567...5,117,843 JBrowse link
G Nlrc5 NLR family CARD domain containing 5 ISO (PMID:20061403) UniProtKB PMID:20061403 NCBI chrNW_004936475:9,137,929...9,218,682 JBrowse link
G Tbk1 TANK binding kinase 1 ISO (MGI:MGI:5792628|PMID:27129230) UniProt PMID:27129230 MGI:MGI:5792628 NCBI chrNW_004936545:2,763,755...2,809,229 JBrowse link
G Trim6 tripartite motif containing 6 ISO (MGI:MGI:5645191|PMID:24882218)
(PMID:24882218)
UniProtKB PMID:24882218 MGI:MGI:5645191 NCBI chrNW_004937097:23,695...31,673 JBrowse link
G Ube2k ubiquitin conjugating enzyme E2 K ISO (PMID:24882218) UniProtKB PMID:24882218 NCBI chrNW_004936482:7,244,972...7,323,263 JBrowse link
G Wnt5a Wnt family member 5A ISO (PMID:19399181) BHF-UCL PMID:19399181 NCBI chrNW_004936473:6,031,627...6,052,211 JBrowse link
G Zbp1 Z-DNA binding protein 1 ISO (MGI:MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:MGI:3718275 NCBI chrNW_004936530:398,980...408,798 JBrowse link
regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc37 cell division cycle 37, HSP90 cochaperone ISO (PMID:16280321) MGI PMID:16280321 NCBI chrNW_004936659:711,165...721,207 JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO (PMID:16280321) MGI PMID:16280321 NCBI chrNW_004936476:15,830,459...15,836,994 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12001
    cellular process 11174
      signal transduction 3699
        cell surface receptor signaling pathway 2023
          cytokine-mediated signaling pathway 262
            type I interferon signaling pathway 34
              negative regulation of type I interferon-mediated signaling pathway + 14
              positive regulation of type I interferon-mediated signaling pathway 13
              regulation of type I interferon-mediated signaling pathway + 27
Path 2
Term Annotations click to browse term
  biological_process 12001
    response to stimulus 6422
      response to biotic stimulus 1088
        response to external biotic stimulus 1054
          response to other organism 1051
            defense response to other organism 588
              innate immune response 356
                response to type I interferon 40
                  cellular response to type I interferon 34
                    type I interferon signaling pathway 34
                      negative regulation of type I interferon-mediated signaling pathway + 14
                      positive regulation of type I interferon-mediated signaling pathway 13
                      regulation of type I interferon-mediated signaling pathway + 27
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.