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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of type I interferon-mediated signaling pathway
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Accession:GO:0060338 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.
Synonyms:exact_synonym: regulation of type I interferon-mediated signalling pathway


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regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC37 cell division cycle 37, HSP90 cochaperone IEA Ensembl GO_REF:0000107 NCBI chr20:50,727,702...50,738,197
Ensembl chr20:50,727,749...50,736,269
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 IEA Ensembl GO_REF:0000107 NCBI chr12:12,658,415...12,664,945
Ensembl chr12:12,660,008...12,664,940
JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific IEA Ensembl GO_REF:0000107 NCBI chr 7:42,762,021...42,785,192
Ensembl chr 7:42,748,136...42,782,999
JBrowse link
G CACTIN cactin, spliceosome C complex subunit IEA Ensembl GO_REF:0000107 NCBI chr20:55,803,494...55,817,467
Ensembl chr20:55,803,530...55,816,549
JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 IEA Ensembl GO_REF:0000107 NCBI chr16:40,554,214...40,571,841
Ensembl chr16:40,555,565...40,571,720
JBrowse link
G DCST1 DC-STAMP domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:42,443,787...42,457,361
Ensembl chr 7:42,428,113...42,457,062
JBrowse link
G METTL3 methyltransferase like 3 IEA Ensembl GO_REF:0000107 NCBI chr15:18,528,755...18,546,303
Ensembl chr15:18,528,772...18,546,531
JBrowse link
G MMP12 matrix metallopeptidase 12 IEA Ensembl GO_REF:0000107 NCBI chr 5:28,918,626...28,933,404
Ensembl chr 5:28,918,594...28,933,309
JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:78,394,013...78,402,032
Ensembl chr 2:78,394,040...78,425,482
JBrowse link
G NLRC5 NLR family CARD domain containing 5 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 2:59,279,535...59,359,327
Ensembl chr 2:59,280,390...59,338,931
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719
JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 IEA Ensembl GO_REF:0000107 NCBI chr24:25,623,997...25,676,336
Ensembl chr24:25,626,134...25,680,902
JBrowse link
G TREX1 three prime repair exonuclease 1 IEA Ensembl GO_REF:0000107 NCBI chr20:40,624,845...40,626,840
Ensembl chr20:40,624,891...40,626,906
JBrowse link
G TTLL12 tubulin tyrosine ligase like 12 IEA Ensembl GO_REF:0000107 NCBI chr10:22,367,590...22,385,167
Ensembl chr10:22,367,367...22,386,617
JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein 2 IEA Ensembl GO_REF:0000107 NCBI chr 2:71,760,232...71,791,420
Ensembl chr 2:71,760,312...71,792,527
JBrowse link
G YTHDF3 YTH N6-methyladenosine RNA binding protein 3 IEA Ensembl GO_REF:0000107 NCBI chr29:13,239,900...13,280,035
Ensembl chr29:13,239,966...13,277,051
JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FADD Fas associated via death domain ISO (PMID:21109225) UniProtKB PMID:21109225 NCBI chr18:48,087,447...48,094,497 JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon IEA Ensembl GO_REF:0000107 NCBI chr38:2,747,303...2,772,574
Ensembl chr38:2,747,297...2,772,587
JBrowse link
G IRF3 interferon regulatory factor 3 ISO (MGI:3718275|PMID:17618271) MGI PMID:17618271 MGI:3718275 NCBI chr 1:106,875,016...106,879,065
Ensembl chr 1:106,875,118...106,879,065
JBrowse link
G LSM14A LSM14A mRNA processing body assembly factor IEA Ensembl GO_REF:0000107 NCBI chr 1:118,061,854...118,117,493
Ensembl chr 1:118,063,512...118,117,478
JBrowse link
G MAVS mitochondrial antiviral signaling protein IEA Ensembl GO_REF:0000107 NCBI chr24:17,510,209...17,529,286
Ensembl chr24:17,512,761...17,523,807
JBrowse link
G MMP12 matrix metallopeptidase 12 IEA Ensembl GO_REF:0000107 NCBI chr 5:28,918,626...28,933,404
Ensembl chr 5:28,918,594...28,933,309
JBrowse link
G NLRC5 NLR family CARD domain containing 5 IEA Ensembl GO_REF:0000107 NCBI chr 2:59,279,535...59,359,327
Ensembl chr 2:59,280,390...59,338,931
JBrowse link
G TBK1 TANK binding kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr10:7,169,664...7,208,890
Ensembl chr10:7,168,007...7,208,899
JBrowse link
G TRIM6 tripartite motif containing 6 IEA Ensembl GO_REF:0000107 NCBI chr21:28,595,887...28,611,562
Ensembl chr21:28,595,448...28,611,124
JBrowse link
G UBE2K ubiquitin conjugating enzyme E2 K IEA Ensembl GO_REF:0000107 NCBI chr 3:72,713,035...72,780,199
Ensembl chr 3:72,717,236...72,780,210
JBrowse link
G WNT5A Wnt family member 5A ISS UniProtKB GO_REF:0000024 NCBI chr20:34,756,430...34,790,937
Ensembl chr20:34,769,930...34,786,673
JBrowse link
G ZBP1 Z-DNA binding protein 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr24:42,583,674...42,589,857
Ensembl chr24:42,584,083...42,589,753
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16186
    cellular process 15465
      signal transduction 5450
        regulation of signal transduction 2787
          regulation of cytokine-mediated signaling pathway 109
            regulation of type I interferon-mediated signaling pathway 26
              negative regulation of type I interferon-mediated signaling pathway + 14
              positive regulation of type I interferon-mediated signaling pathway 12
Path 2
Term Annotations click to browse term
  biological_process 16186
    response to stimulus 8555
      response to external stimulus 2814
        response to external biotic stimulus 1391
          response to other organism 1387
            defense response to other organism 819
              innate immune response 555
                response to type I interferon 48
                  cellular response to type I interferon 42
                    type I interferon signaling pathway 38
                      regulation of type I interferon-mediated signaling pathway 26
                        negative regulation of type I interferon-mediated signaling pathway + 14
                        positive regulation of type I interferon-mediated signaling pathway 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.