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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of type I interferon-mediated signaling pathway
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Accession:GO:0060339 term browser browse the term
Definition:Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.
Synonyms:exact_synonym: negative regulation of type I interferon-mediated signalling pathway


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negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific IEA Ensembl GO_REF:0000107 NCBI chr 7:42,762,021...42,785,192
Ensembl chr 7:42,748,136...42,782,999
JBrowse link
G CACTIN cactin, spliceosome C complex subunit IEA Ensembl GO_REF:0000107 NCBI chr20:55,803,494...55,817,467
Ensembl chr20:55,803,530...55,816,549
JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 IEA Ensembl GO_REF:0000107 NCBI chr16:40,554,214...40,571,841
Ensembl chr16:40,555,565...40,571,720
JBrowse link
G DCST1 DC-STAMP domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:42,443,787...42,457,361
Ensembl chr 7:42,428,113...42,457,062
JBrowse link
G METTL3 methyltransferase like 3 IEA Ensembl GO_REF:0000107 NCBI chr15:18,528,755...18,546,303
Ensembl chr15:18,528,772...18,546,531
JBrowse link
G MMP12 matrix metallopeptidase 12 IEA Ensembl GO_REF:0000107 NCBI chr 5:28,918,626...28,933,404
Ensembl chr 5:28,918,594...28,933,309
JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:78,394,013...78,402,032
Ensembl chr 2:78,394,040...78,425,482
JBrowse link
G NLRC5 NLR family CARD domain containing 5 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 2:59,279,535...59,359,327
Ensembl chr 2:59,280,390...59,338,931
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719
JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 IEA Ensembl GO_REF:0000107 NCBI chr24:25,623,997...25,676,336
Ensembl chr24:25,626,134...25,680,902
JBrowse link
G TREX1 three prime repair exonuclease 1 IEA Ensembl GO_REF:0000107 NCBI chr20:40,624,845...40,626,840
Ensembl chr20:40,624,891...40,626,906
JBrowse link
G TTLL12 tubulin tyrosine ligase like 12 IEA Ensembl GO_REF:0000107 NCBI chr10:22,367,590...22,385,167
Ensembl chr10:22,367,367...22,386,617
JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein 2 IEA Ensembl GO_REF:0000107 NCBI chr 2:71,760,232...71,791,420
Ensembl chr 2:71,760,312...71,792,527
JBrowse link
G YTHDF3 YTH N6-methyladenosine RNA binding protein 3 IEA Ensembl GO_REF:0000107 NCBI chr29:13,239,900...13,280,035
Ensembl chr29:13,239,966...13,277,051
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16186
    cellular process 15465
      signal transduction 5450
        negative regulation of signal transduction 1215
          negative regulation of cytokine-mediated signaling pathway 54
            negative regulation of type I interferon-mediated signaling pathway 14
              suppression by virus of host type I interferon-mediated signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 16186
    response to stimulus 8555
      response to biotic stimulus 1424
        response to external biotic stimulus 1391
          response to other organism 1387
            defense response to other organism 819
              innate immune response 555
                response to type I interferon 48
                  cellular response to type I interferon 42
                    type I interferon signaling pathway 38
                      regulation of type I interferon-mediated signaling pathway 26
                        negative regulation of type I interferon-mediated signaling pathway 14
                          suppression by virus of host type I interferon-mediated signaling pathway 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.