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ONTOLOGY REPORT - ANNOTATIONS


Term:growth hormone receptor signaling pathway
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Accession:GO:0060396 term browser browse the term
Definition:The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
Synonyms:exact_synonym: growth hormone receptor signalling pathway
 related_synonym: GH receptor signaling pathway;   cellular response to growth hormone


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growth hormone receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gh1 growth hormone 1 ISO
IBA
(PMID:8063815)
PMID:21873635
RGD PMID:8063815, PMID:21873635 RGD:13792537 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Ghr growth hormone receptor ISO
IBA
IDA
(PMID:7565946)
PMID:21873635
(PMID:8702683)
(MGI:MGI:82362|PMID:8702683)
PMID:8063815
RGD PMID:7565946, PMID:8702683, PMID:21873635, PMID:8063815 MGI:MGI:82362, RGD:13792537, RGD:8553732 NCBI chr 2:53,149,225...53,413,954
Ensembl chr 2:53,150,370...53,413,638
JBrowse link
G Jak2 Janus kinase 2 ISO (PMID:10925297) RGD PMID:10925297 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO
IEA
(PMID:7782332)
GO_REF:0000107
RGD
Ensembl
PMID:7782332 GO_REF:0000107 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO
IEA
(PMID:10925297)
GO_REF:0000107
RGD
Ensembl
PMID:10925297 GO_REF:0000107 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Pxn paxillin ISO (PMID:10925297) RGD PMID:10925297 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Socs2 suppressor of cytokine signaling 2 ISO
IEA
(PMID:12552091)
GO_REF:0000107
RGD
Ensembl
PMID:12552091 GO_REF:0000107 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO (PMID:10925297) RGD PMID:10925297 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
growth hormone receptor signaling pathway via JAK-STAT term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak2 Janus kinase 2 IDA
ISO
ISS
(MGI:MGI:3828422|PMID:8923468), (MGI:MGI:4457458|PMID:20304997)
GO_REF:0000024
RGD
UniProt
PMID:8923468, PMID:20304997, PMID:11244571 GO_REF:0000024, MGI:MGI:3828422, MGI:MGI:4457458, RGD:1624962 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
IBA
ISS
(PMID:12552091)
PMID:21873635
GO_REF:0000024
(MGI:MGI:3828422|PMID:8923468)
RGD
UniProt
PMID:8923468, PMID:12552091, PMID:21873635 GO_REF:0000024, MGI:MGI:3828422, RGD:13792537 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO
IBA
IEA
(MGI:MGI:82362|PMID:8702683)
PMID:21873635
GO_REF:0000002
RGD
InterPro
PMID:8702683, PMID:21873635 GO_REF:0000002, MGI:MGI:82362, RGD:13792537 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO
IEA
IBA
(PMID:12552091)
GO_REF:0000107
PMID:21873635
GO_REF:0000002
(MGI:MGI:3828422|PMID:8923468)
RGD
Ensembl
InterPro
PMID:8923468, PMID:12552091, PMID:21873635 GO_REF:0000002, GO_REF:0000107, MGI:MGI:3828422, RGD:13792537 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Stat6 signal transducer and activator of transcription 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
negative regulation of growth hormone receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdf15 growth differentiation factor 15 ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:6154425|PMID:28572090)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:28572090 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6154425 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Leprot leptin receptor overlapping transcript ISO
IBA
(PMID:19907080)
PMID:21873635
RGD PMID:19907080, PMID:21873635 RGD:13792537 NCBI chr 5:120,498,910...120,511,011
Ensembl chr 5:120,498,883...120,511,017
JBrowse link
positive regulation of growth hormone receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrm1 adhesion regulating molecule 1 ISO (MGI:MGI:4849324|PMID:21048919) RGD PMID:21048919 MGI:MGI:4849324 NCBI chr 3:175,548,181...175,552,943
Ensembl chr 3:175,548,174...175,552,947
JBrowse link
G Jak2 Janus kinase 2 ISO (MGI:MGI:3836108|PMID:17761766) RGD PMID:17761766 MGI:MGI:3836108 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Mbd5 methyl-CpG binding domain protein 5 ISO MGI:MGI:5466580 (MGI:MGI:5464176|PMID:23077600) RGD PMID:23077600 MGI:MGI:5464176 NCBI chr 3:33,364,812...33,504,144
Ensembl chr 3:33,440,191...33,504,238
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      signal transduction 7015
        cell surface receptor signaling pathway 2782
          enzyme linked receptor protein signaling pathway 963
            transmembrane receptor protein tyrosine kinase signaling pathway 605
              growth hormone receptor signaling pathway 15
                growth hormone receptor signaling pathway via JAK-STAT 5
                negative regulation of growth hormone receptor signaling pathway 2
                positive regulation of growth hormone receptor signaling pathway 3
                regulation of growth hormone receptor signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      response to chemical 6330
        response to organic substance 3853
          response to organonitrogen compound 1453
            cellular response to organonitrogen compound 848
              cellular response to peptide 462
                cellular response to peptide hormone stimulus 387
                  cellular response to growth hormone stimulus 21
                    growth hormone receptor signaling pathway 15
                      growth hormone receptor signaling pathway via JAK-STAT 5
                      negative regulation of growth hormone receptor signaling pathway 2
                      positive regulation of growth hormone receptor signaling pathway 3
                      regulation of growth hormone receptor signaling pathway + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.