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ONTOLOGY REPORT - ANNOTATIONS


Term:epithelial tube branching involved in lung morphogenesis
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Accession:GO:0060441 term browser browse the term
Definition:The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
Synonyms:exact_synonym: lung branching morphogenesis


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epithelial tube branching involved in lung morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:2306315
RGD:1624291
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:1624291
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:1624291
G Ctsz cathepsin Z JBrowse link 3 172,527,107 172,537,877 RGD:1624291
G Dag1 dystroglycan 1 JBrowse link 8 116,980,501 116,993,182 RGD:1624291
G Dlg5 discs large MAGUK scaffold protein 5 JBrowse link 15 120,213 230,312 RGD:1624291
G Esrp1 epithelial splicing regulatory protein 1 JBrowse link 5 24,576,988 24,631,758 RGD:1624291
G Esrp2 epithelial splicing regulatory protein 2 JBrowse link 19 38,113,412 38,120,578 RGD:1624291
RGD:1600115
G Fgf10 fibroblast growth factor 10 JBrowse link 2 51,673,480 51,747,533 RGD:1624291
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:1624291
G Foxa1 forkhead box A1 JBrowse link 6 78,516,579 78,549,669 RGD:1624291
RGD:1600115
G Foxa2 forkhead box A2 JBrowse link 3 142,383,084 142,387,493 RGD:1624291
G Foxf1 forkhead box F1 JBrowse link 19 53,012,306 53,016,100 RGD:1624291
G Hhip Hedgehog-interacting protein JBrowse link 19 31,525,134 31,614,487 RGD:1624291
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
G Hoxa5 homeo box A5 RGD:1624291
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:1624291
G Lama1 laminin subunit alpha 1 JBrowse link 9 115,916,907 116,042,123 RGD:1624291
G Nkx2-1 NK2 homeobox 1 JBrowse link 6 77,418,096 77,423,383 RGD:1600115
RGD:1624291
G Rspo2 R-spondin 2 JBrowse link 7 81,919,911 82,059,659 RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:2306315
RGD:1624291
G Sox2 SRY-box transcription factor 2 JBrowse link 2 121,165,137 121,167,545 RGD:1624291
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:1624291
bud dilation involved in lung branching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
bud elongation involved in lung branching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Fgf10 fibroblast growth factor 10 JBrowse link 2 51,673,480 51,747,533 RGD:1624291
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:1624291
G Rdh10 retinol dehydrogenase 10 JBrowse link 5 2,605,265 2,631,905 RGD:1624291
G Spry1 sprouty RTK signaling antagonist 1 JBrowse link 2 124,400,689 124,405,331 RGD:1624291
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:1624291
G Yap1 Yes1 associated transcriptional regulator JBrowse link 8 6,133,014 6,204,240 RGD:1624291
bud outgrowth involved in lung branching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgf10 fibroblast growth factor 10 JBrowse link 2 51,673,480 51,747,533 RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 JBrowse link 7 40,171,957 40,217,056 RGD:1624291
G Tnc tenascin C JBrowse link 5 79,789,686 79,874,555 RGD:4889612
dichotomous subdivision of terminal units involved in lung branching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctsh cathepsin H JBrowse link 8 97,439,155 97,458,293 RGD:1624291
RGD:1600115
lateral sprouting involved in lung morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 JBrowse link 7 126,774,010 126,914,085 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
lung induction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1600115
RGD:1624291
G Wnt2 Wnt family member 2 JBrowse link 4 45,286,845 45,332,899 RGD:1624291
G Wnt2b Wnt family member 2B JBrowse link 2 207,433,771 207,457,094 RGD:1624291
negative regulation of branching involved in lung morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 JBrowse link 7 126,774,010 126,914,085 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 JBrowse link 7 126,774,010 126,914,085 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
positive regulation of branching involved in lung morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1600115
RGD:1624291
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:11087558
primary lung bud formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hhex hematopoietically expressed homeobox JBrowse link 1 256,101,994 256,107,581 RGD:1624291
G Rdh10 retinol dehydrogenase 10 JBrowse link 5 2,605,265 2,631,905 RGD:1624291
regulation of branching involved in lung morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    multicellular organismal process 8951
      morphogenesis of a branching structure 247
        morphogenesis of a branching epithelium 228
          branching morphogenesis of an epithelial tube 191
            epithelial tube branching involved in lung morphogenesis 38
              bud dilation involved in lung branching + 1
              bud elongation involved in lung branching 7
              bud outgrowth involved in lung branching + 4
              dichotomous subdivision of terminal units involved in lung branching + 3
              lateral sprouting involved in lung morphogenesis 2
              negative regulation of branching involved in lung morphogenesis + 1
              positive regulation of branching involved in lung morphogenesis + 5
              primary lung bud formation + 5
              regulation of branching involved in lung morphogenesis + 7
Path 2
Term Annotations click to browse term
  biological_process 19858
    developmental process 6734
      anatomical structure development 6180
        multicellular organism development 5638
          system development 5213
            animal organ development 3974
              respiratory tube development 261
                lung development 258
                  lung morphogenesis 70
                    epithelial tube branching involved in lung morphogenesis 38
                      bud dilation involved in lung branching + 1
                      bud elongation involved in lung branching 7
                      bud outgrowth involved in lung branching + 4
                      dichotomous subdivision of terminal units involved in lung branching + 3
                      lateral sprouting involved in lung morphogenesis 2
                      negative regulation of branching involved in lung morphogenesis + 1
                      positive regulation of branching involved in lung morphogenesis + 5
                      primary lung bud formation + 5
                      regulation of branching involved in lung morphogenesis + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.