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ONTOLOGY REPORT - ANNOTATIONS


Term:lung epithelial cell differentiation
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Accession:GO:0060487 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.
Synonyms:related_synonym: pulmonary epithelial cell differentiation


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lung epithelial cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 ISO MGI:MGI:107423|MGI:MGI:1917942|MGI:MGI:1923373|MGI:MGI:2443665 (MGI:MGI:4950299|PMID:21385765) RGD PMID:21385765 MGI:MGI:4950299 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G Foxa1 forkhead box A1 ISO
IEA
MGI:MGI:1347476 (MGI:MGI:3579763|PMID:15668254)
GO_REF:0000107
RGD
Ensembl
PMID:15668254 GO_REF:0000107, MGI:MGI:3579763 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Foxa2 forkhead box A2 ISO MGI:MGI:1347472 (MGI:MGI:3579763|PMID:15668254) RGD PMID:15668254 MGI:MGI:3579763 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Gpsm2 G-protein signaling modulator 2 ISO (MGI:MGI:4950299|PMID:21385765) RGD PMID:21385765 MGI:MGI:4950299 NCBI chr 2:211,480,120...211,528,096
Ensembl chr 2:211,480,400...211,527,919
JBrowse link
G Grhl2 grainyhead-like transcription factor 2 ISO (MGI:MGI:5613464|PMID:22955271) RGD PMID:22955271 MGI:MGI:5613464 NCBI chr 7:76,058,623...76,197,360
Ensembl chr 7:76,059,386...76,197,856
JBrowse link
G Insc INSC, spindle orientation adaptor protein ISO (MGI:MGI:4950299|PMID:21385765) RGD PMID:21385765 MGI:MGI:4950299 NCBI chr 1:184,299,200...184,407,487
Ensembl chr 1:184,299,250...184,407,480
JBrowse link
G Numa1 nuclear mitotic apparatus protein 1 ISO (MGI:MGI:4950299|PMID:21385765) RGD PMID:21385765 MGI:MGI:4950299 NCBI chr 1:167,044,544...167,091,453
Ensembl chr 1:167,051,209...167,091,453
JBrowse link
G Numb NUMB, endocytic adaptor protein ISO (MGI:MGI:4950299|PMID:21385765) RGD PMID:21385765 MGI:MGI:4950299 NCBI chr 6:107,279,917...107,325,345
Ensembl chr 6:107,279,920...107,325,345
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha ISO MGI:MGI:3044031 (MGI:MGI:3689244|PMID:16998587) RGD PMID:16998587 MGI:MGI:3689244 NCBI chr14:100,311,224...100,360,879
Ensembl chr14:100,311,173...100,360,879
JBrowse link
G Sav1 salvador family WW domain containing protein 1 ISO MGI:MGI:3790763 (MGI:MGI:3785211|PMID:18369314) RGD PMID:18369314 MGI:MGI:3785211 NCBI chr 6:92,376,470...92,398,678
Ensembl chr 6:92,376,093...92,398,525
JBrowse link
G Sox9 SRY-box transcription factor 9 ISO (MGI:MGI:5523731|PMID:24191021) RGD PMID:24191021 MGI:MGI:5523731 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Tmem38b transmembrane protein 38B ISO MGI:MGI:3716065 (MGI:MGI:3850579|PMID:19515693) RGD PMID:19515693 MGI:MGI:3850579 NCBI chr 5:70,639,156...70,675,055
Ensembl chr 5:70,639,156...70,675,054
JBrowse link
G Yap1 Yes1 associated transcriptional regulator ISO MGI:MGI:3053959|MGI:MGI:5316446 (MGI:MGI:5586932|PMID:25043473) RGD PMID:25043473 MGI:MGI:5586932 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
club cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 ISO
IEA
MGI:MGI:108067 (MGI:MGI:3695537|PMID:17164424)
GO_REF:0000107
RGD
Ensembl
PMID:17164424 GO_REF:0000107, MGI:MGI:3695537 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Nfib nuclear factor I/B ISO
ISS
(MGI:MGI:5049839|PMID:21513708)
GO_REF:0000024
RGD
UniProt
PMID:21513708 GO_REF:0000024, MGI:MGI:5049839 NCBI chr 5:100,436,343...100,647,962
Ensembl chr 5:100,439,082...100,647,727
JBrowse link
G Nkx2-1 NK2 homeobox 1 ISO
IEA
MGI:MGI:107516 (MGI:MGI:3695537|PMID:17164424)
GO_REF:0000107
RGD
Ensembl
PMID:17164424 GO_REF:0000107, MGI:MGI:3695537 NCBI chr 6:77,418,096...77,423,383
Ensembl chr 6:77,418,096...77,421,286
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO MGI:MGI:3583755 (MGI:MGI:5440802|PMID:22797898) RGD PMID:22797898 MGI:MGI:5440802 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
lung ciliated cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfib nuclear factor I/B ISO
ISS
(MGI:MGI:5049839|PMID:21513708)
GO_REF:0000024
RGD
UniProt
PMID:21513708 GO_REF:0000024, MGI:MGI:5049839 NCBI chr 5:100,436,343...100,647,962
Ensembl chr 5:100,439,082...100,647,727
JBrowse link
lung goblet cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member ISO (MGI:MGI:5429471|PMID:22675208) RGD PMID:22675208 MGI:MGI:5429471 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Hoxa5 homeo box A5 ISO MGI:MGI:2150397 (MGI:MGI:3665532|PMID:17003488) RGD PMID:17003488 MGI:MGI:3665532
G Spdef SAM pointed domain containing ets transcription factor ISO (MGI:MGI:3709719|PMID:17347682) RGD PMID:17347682 MGI:MGI:3709719 NCBI chr20:7,292,823...7,308,053
Ensembl chr20:7,292,824...7,307,284
JBrowse link
lung neuroendocrine cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 ISO MGI:MGI:1857470 (MGI:MGI:3664178|PMID:9126746) RGD PMID:9126746 MGI:MGI:3664178 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
lung secretory cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp1 forkhead box P1 ISO MGI:MGI:1921373 (MGI:MGI:5429471|PMID:22675208) RGD PMID:22675208 MGI:MGI:5429471 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
G Foxp4 forkhead box P4 ISO MGI:MGI:1914004 (MGI:MGI:5429471|PMID:22675208) RGD PMID:22675208 MGI:MGI:5429471 NCBI chr 9:15,068,378...15,124,962
Ensembl chr 9:15,068,399...15,125,318
JBrowse link
negative regulation of lung goblet cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp1 forkhead box P1 ISO MGI:MGI:1921373 (MGI:MGI:5429471|PMID:22675208) RGD PMID:22675208 MGI:MGI:5429471 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
G Foxp4 forkhead box P4 ISO MGI:MGI:1914004 (MGI:MGI:5429471|PMID:22675208) RGD PMID:22675208 MGI:MGI:5429471 NCBI chr 9:15,068,378...15,124,962
Ensembl chr 9:15,068,399...15,125,318
JBrowse link
positive regulation of lung ciliated cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj1 forkhead box J1 ISO (PMID:20539013) RGD PMID:20539013 NCBI chr10:105,282,090...105,289,396 JBrowse link
regulation of lung goblet cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp1 forkhead box P1 ISO MGI:MGI:1344405|MGI:MGI:1921373 (MGI:MGI:5429471|PMID:22675208) RGD PMID:22675208 MGI:MGI:5429471 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
G Foxp4 forkhead box P4 ISO MGI:MGI:1344405|MGI:MGI:1914004 (MGI:MGI:5429471|PMID:22675208) RGD PMID:22675208 MGI:MGI:5429471 NCBI chr 9:15,068,378...15,124,962
Ensembl chr 9:15,068,399...15,125,318
JBrowse link
type I pneumocyte differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 ISO MGI:MGI:4999627 (MGI:MGI:4950818|PMID:21408140) RGD PMID:21408140 MGI:MGI:4950818 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Igf1 insulin-like growth factor 1 ISO MGI:MGI:1926485 (MGI:MGI:3640953|PMID:16691571) RGD PMID:16691571 MGI:MGI:3640953 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Klf2 Kruppel-like factor 2 ISO (MGI:MGI:5297307|PMID:22001906) RGD PMID:22001906 MGI:MGI:5297307 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Lta4h leukotriene A4 hydrolase IEP RGD PMID:15805137 RGD:2316585 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO MGI:MGI:3829987|MGI:MGI:98742|MGI:MGI:98743 (MGI:MGI:5297307|PMID:22001906) RGD PMID:22001906 MGI:MGI:5297307 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Nfib nuclear factor I/B ISO
ISS
(MGI:MGI:5049839|PMID:21513708)
GO_REF:0000024
RGD
UniProt
PMID:21513708 GO_REF:0000024, MGI:MGI:5049839 NCBI chr 5:100,436,343...100,647,962
Ensembl chr 5:100,439,082...100,647,727
JBrowse link
G Thra thyroid hormone receptor alpha ISO
IEA
MGI:MGI:1337080|MGI:MGI:98743 (MGI:MGI:5297307|PMID:22001906)
GO_REF:0000107
RGD
Ensembl
PMID:22001906 GO_REF:0000107, MGI:MGI:5297307 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta ISO
IEA
MGI:MGI:1337080|MGI:MGI:98742 (MGI:MGI:5297307|PMID:22001906)
GO_REF:0000107
RGD
Ensembl
PMID:22001906 GO_REF:0000107, MGI:MGI:5297307 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
type II pneumocyte differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 ISO MGI:MGI:3497919 (MGI:MGI:2665161|PMID:12819782) RGD PMID:12819782 MGI:MGI:2665161 NCBI chr12:12,738,784...12,748,345
Ensembl chr12:12,738,812...12,748,345
JBrowse link
G Fgf10 fibroblast growth factor 10 ISO (MGI:MGI:3577664|PMID:15531758) RGD PMID:15531758 MGI:MGI:3577664 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Fndc3b fibronectin type III domain containing 3B ISO MGI:MGI:4822558 (MGI:MGI:5298325|PMID:21704616) RGD PMID:21704616 MGI:MGI:5298325 NCBI chr 2:113,109,949...113,415,171
Ensembl chr 2:113,112,902...113,345,577
JBrowse link
G Gata6 GATA binding protein 6 ISO
IEA
MGI:MGI:108067 (MGI:MGI:3695537|PMID:17164424)
GO_REF:0000107
RGD
Ensembl
PMID:17164424 GO_REF:0000107, MGI:MGI:3695537 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Igf1 insulin-like growth factor 1 ISO MGI:MGI:1926485 (MGI:MGI:3640953|PMID:16691571) RGD PMID:16691571 MGI:MGI:3640953 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Nfib nuclear factor I/B ISO
ISS
(MGI:MGI:5049839|PMID:21513708)
GO_REF:0000024
RGD
UniProt
PMID:21513708 GO_REF:0000024, MGI:MGI:5049839 NCBI chr 5:100,436,343...100,647,962
Ensembl chr 5:100,439,082...100,647,727
JBrowse link
G Nkx2-1 NK2 homeobox 1 ISO
IEA
MGI:MGI:107516 (MGI:MGI:3695537|PMID:17164424)
GO_REF:0000107
RGD
Ensembl
PMID:17164424 GO_REF:0000107, MGI:MGI:3695537 NCBI chr 6:77,418,096...77,423,383
Ensembl chr 6:77,418,096...77,421,286
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    cellular process 18791
      cellular developmental process 4444
        cell differentiation 4346
          epithelial cell differentiation 707
            lung epithelial cell differentiation 34
              club cell differentiation 4
              lung ciliated cell differentiation + 2
              lung secretory cell differentiation + 13
              type I pneumocyte differentiation 8
Path 2
Term Annotations click to browse term
  biological_process 20017
    developmental process 6813
      anatomical structure development 6256
        multicellular organism development 5735
          system development 5272
            animal organ development 4027
              respiratory tube development 264
                lung development 261
                  lung cell differentiation 35
                    lung epithelial cell differentiation 34
                      club cell differentiation 4
                      lung ciliated cell differentiation + 2
                      lung secretory cell differentiation + 13
                      type I pneumocyte differentiation 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.