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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of calcidiol 1-monooxygenase activity
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Accession:GO:0060558 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.


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regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vdr vitamin D receptor ISO
IEA
(MGI:MGI:1097206|PMID:9295274)
GO_REF:0000107
RGD
Ensembl
PMID:9295274 GO_REF:0000107, MGI:MGI:1097206 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 ISO (PMID:16549446) RGD PMID:16549446 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor ISO (PMID:15947108) RGD PMID:15947108 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO
IEA
(PMID:15243130)
GO_REF:0000107
RGD
Ensembl
PMID:15243130 GO_REF:0000107 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
positive regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma ISO (PMID:9282826) RGD PMID:9282826 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta IEA
ISO
GO_REF:0000107
(PMID:16720713), (PMID:17023519)
Ensembl
RGD
PMID:16720713, PMID:17023519 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Tnf tumor necrosis factor ISO (PMID:1690216) RGD PMID:1690216 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    metabolic process 12259
      regulation of metabolic process 7010
        regulation of oxidoreductase activity 102
          regulation of monooxygenase activity 49
            regulation of calcidiol 1-monooxygenase activity 7
              negative regulation of calcidiol 1-monooxygenase activity 3
              positive regulation of calcidiol 1-monooxygenase activity 3
Path 2
Term Annotations click to browse term
  biological_process 20015
    biological regulation 13760
      regulation of biological process 13073
        regulation of metabolic process 7010
          regulation of primary metabolic process 6031
            regulation of lipid metabolic process 397
              regulation of lipid biosynthetic process 198
                regulation of steroid biosynthetic process 85
                  regulation of vitamin D biosynthetic process 9
                    regulation of calcidiol 1-monooxygenase activity 7
                      negative regulation of calcidiol 1-monooxygenase activity 3
                      positive regulation of calcidiol 1-monooxygenase activity 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.