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ONTOLOGY REPORT - ANNOTATIONS


Term:mammary gland duct morphogenesis
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Accession:GO:0060603 term browser browse the term
Definition:The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk.


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mammary gland duct morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO (MGI:2151643|PMID:11783999) MGI PMID:11783999 MGI:2151643 NCBI chrNW_004936469:49,616,552...49,788,760 JBrowse link
G Lrp5 LDL receptor related protein 5 ISO (MGI:3849913|PMID:19503830) MGI PMID:19503830 MGI:3849913 NCBI chrNW_004936599:1,746,309...1,814,471 JBrowse link
G Lrp6 LDL receptor related protein 6 ISO (MGI:3849913|PMID:19503830) MGI PMID:19503830 MGI:3849913 NCBI chrNW_004936587:5,065,200...5,143,029 JBrowse link
G Nr3c1 nuclear receptor subfamily 3 group C member 1 ISO (MGI:3758540|PMID:12198239) MGI PMID:12198239 MGI:3758540 NCBI chrNW_004936504:10,960,069...11,056,834 JBrowse link
G Ntn1 netrin 1 ISO (MGI:3617129|PMID:16439476) MGI PMID:16439476 MGI:3617129 NCBI chrNW_004936595:2,146,371...2,323,346 JBrowse link
G Ptch1 patched 1 ISO (MGI:1346456|PMID:10529434) MGI PMID:10529434 MGI:1346456 NCBI chrNW_004936626:4,241,993...4,301,919 JBrowse link
G Scrib scribble planar cell polarity protein ISO (MGI:4359580|PMID:19041750) UniProt PMID:19041750 MGI:4359580 NCBI chrNW_004936470:8,349,175...8,370,099 JBrowse link
G Slit2 slit guidance ligand 2 ISO (MGI:3617129|PMID:16439476) MGI PMID:16439476 MGI:3617129 NCBI chrNW_004936477:8,111,212...8,448,567 JBrowse link
branch elongation involved in mammary gland duct branching term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor beta 1 ISO (MGI:3814777|PMID:18614704) MGI PMID:18614704 MGI:3814777 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
branching involved in mammary gland duct morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase ISO (MGI:3054694|PMID:15340078) MGI PMID:15340078 MGI:3054694 NCBI chrNW_004936600:4,215,219...4,424,498 JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO (MGI:3640884|PMID:10804170) MGI PMID:10804170 MGI:3640884 NCBI chrNW_004936538:835,436...848,907 JBrowse link
G Csf1 colony stimulating factor 1 ISO (MGI:3640884|PMID:10804170) MGI PMID:10804170 MGI:3640884 NCBI chrNW_004936704:1,372,137...1,393,355 JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 ISO (MGI:1932625|PMID:11283268) MGI PMID:11283268 MGI:1932625 NCBI chrNW_004936837:523,227...538,799 JBrowse link
G Epha2 EPH receptor A2 ISO (MGI:5284750|PMID:19321667) UniProt PMID:19321667 MGI:5284750 NCBI chrNW_004936474:3,648,395...3,673,856 JBrowse link
G Etv4 ETS variant transcription factor 4 ISO (MGI:2667785|PMID:12871699)
(MGI:3828920|PMID:18977342)
MGI PMID:12871699, PMID:18977342 MGI:2667785, MGI:3828920 NCBI chrNW_004936541:120,533...138,463 JBrowse link
G Kdm5b lysine demethylase 5B ISO (MGI:5619178|PMID:24802759) MGI PMID:24802759 MGI:5619178 NCBI chrNW_004936567:1,782,056...1,860,861 JBrowse link
G Lrp5 LDL receptor related protein 5 ISO (MGI:3692480|PMID:16973609) MGI PMID:16973609 MGI:3692480 NCBI chrNW_004936599:1,746,309...1,814,471 JBrowse link
G Lrp6 LDL receptor related protein 6 ISO (MGI:3849913|PMID:19503830) MGI PMID:19503830 MGI:3849913 NCBI chrNW_004936587:5,065,200...5,143,029 JBrowse link
G Msx2 msh homeobox 2 ISO (MGI:1355063|PMID:10742104) MGI PMID:10742104 MGI:1355063 NCBI chrNW_004936609:1,216,436...1,221,528 JBrowse link
G Pml PML nuclear body scaffold ISO (MGI:3839212|PMID:19261859) MGI PMID:19261859 MGI:3839212 NCBI chrNW_004936471:33,135,186...33,173,218 JBrowse link
G Slc12a2 solute carrier family 12 member 2 ISO (MGI:2180693|PMID:8864124) MGI PMID:8864124 MGI:2180693 NCBI chrNW_004936504:1,378,812...1,465,463 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO (MGI:3589531|PMID:16007215) MGI PMID:16007215 MGI:3589531 NCBI chrNW_004936561:3,826,802...3,844,406 JBrowse link
G Tbx3 T-box transcription factor 3 ISO (MGI:3608166|PMID:16222716) MGI PMID:16222716 MGI:3608166 NCBI chrNW_004936558:7,230,361...7,243,651 JBrowse link
dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin ISO (MGI:3703920|PMID:17369357) MGI PMID:17369357 MGI:3703920 NCBI chrNW_004936598:1,276,599...1,283,612 JBrowse link
G Tfap2c transcription factor AP-2 gamma ISO (MGI:4422106|PMID:20131354) MGI PMID:20131354 MGI:4422106 NCBI chrNW_004936875:491,032...498,732 JBrowse link
epithelial cell proliferation involved in mammary gland duct elongation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin ISO (MGI:3703920|PMID:17369357) MGI PMID:17369357 MGI:3703920 NCBI chrNW_004936598:1,276,599...1,283,612 JBrowse link
G Esr1 estrogen receptor 1 ISO (MGI:3629536|PMID:12021201) MGI PMID:12021201 MGI:3629536 NCBI chrNW_004936489:4,616,839...4,887,179 JBrowse link
G Med1 mediator complex subunit 1 ISO (MGI:3576991|PMID:15647257) MGI PMID:15647257 MGI:3576991 NCBI chrNW_004936490:14,625,201...14,663,184 JBrowse link
G Tfap2c transcription factor AP-2 gamma ISO (MGI:4422106|PMID:20131354) MGI PMID:20131354 MGI:4422106 NCBI chrNW_004936875:491,032...498,732 JBrowse link
G Wnt5a Wnt family member 5A ISO (MGI:3761053|PMID:17898001) MGI PMID:17898001 MGI:3761053 NCBI chrNW_004936473:6,031,627...6,052,211 JBrowse link
lateral sprouting involved in mammary gland duct morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor ISO (MGI:2683859|PMID:14676301) MGI PMID:14676301 MGI:2683859 NCBI chrNW_004936635:485,903...647,820 JBrowse link
G Wnt5a Wnt family member 5A ISO (MGI:3761053|PMID:17898001) MGI PMID:17898001 MGI:3761053 NCBI chrNW_004936473:6,031,627...6,052,211 JBrowse link
mammary duct terminal end bud growth term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 ISO (MGI:3640884|PMID:10804170) MGI PMID:10804170 MGI:3640884 NCBI chrNW_004936538:835,436...848,907 JBrowse link
G Csf1 colony stimulating factor 1 ISO (MGI:3640884|PMID:10804170) MGI PMID:10804170 MGI:3640884 NCBI chrNW_004936704:1,372,137...1,393,355 JBrowse link
G Kdm5b lysine demethylase 5B ISO (MGI:5619178|PMID:24802759) MGI PMID:24802759 MGI:5619178 NCBI chrNW_004936567:1,782,056...1,860,861 JBrowse link
G Mst1 macrophage stimulating 1 ISO (MGI:5614192|PMID:25049204) MGI PMID:25049204 MGI:5614192 NCBI chrNW_004936529:1,298,853...1,306,088 JBrowse link
G Robo1 roundabout guidance receptor 1 ISO (MGI:3617129|PMID:16439476) MGI PMID:16439476 MGI:3617129 NCBI chrNW_004936505:4,329,428...4,711,310 JBrowse link
G Slc12a2 solute carrier family 12 member 2 ISO (MGI:2180453|PMID:12040017) MGI PMID:12040017 MGI:2180453 NCBI chrNW_004936504:1,378,812...1,465,463 JBrowse link
G Slit2 slit guidance ligand 2 ISO (MGI:3617129|PMID:16439476) MGI PMID:16439476 MGI:3617129 NCBI chrNW_004936477:8,111,212...8,448,567 JBrowse link
mammary gland branching involved in pregnancy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csmd1 CUB and Sushi multiple domains 1 ISO (MGI:6369467|PMID:31604923) MGI PMID:31604923 MGI:6369467 NCBI chrNW_004936615:1,677,845...2,063,781 JBrowse link
G Esr1 estrogen receptor 1 ISO (MGI:1926565|PMID:10919287) MGI PMID:10919287 MGI:1926565 NCBI chrNW_004936489:4,616,839...4,887,179 JBrowse link
G Med1 mediator complex subunit 1 ISO (MGI:3576991|PMID:15647257) MGI PMID:15647257 MGI:3576991 NCBI chrNW_004936490:14,625,201...14,663,184 JBrowse link
G Vdr vitamin D receptor ISO (MGI:3051725|PMID:15178742) MGI PMID:15178742 MGI:3051725 NCBI chrNW_004936512:5,741,836...5,800,999 JBrowse link
mammary gland branching involved in thelarche term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin ISO (MGI:1336843|PMID:10331984), (MGI:3703920|PMID:17369357) MGI PMID:10331984, PMID:17369357 MGI:1336843, MGI:3703920 NCBI chrNW_004936598:1,276,599...1,283,612 JBrowse link
G Med1 mediator complex subunit 1 ISO (MGI:3576991|PMID:15647257) MGI PMID:15647257 MGI:3576991 NCBI chrNW_004936490:14,625,201...14,663,184 JBrowse link
G Ncoa3 nuclear receptor coactivator 3 ISO (MGI:1859522|PMID:11015591) MGI PMID:11015591 MGI:1859522 NCBI chrNW_004936514:5,900,135...5,967,862 JBrowse link
G Phb2 prohibitin 2 ISO (MGI:3695669|PMID:17065319) MGI PMID:17065319 MGI:3695669 NCBI chrNW_004936709:854,493...859,182 JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO (MGI:3814777|PMID:18614704) MGI PMID:18614704 MGI:3814777 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Wnt5a Wnt family member 5A ISO (MGI:3761053|PMID:17898001) MGI PMID:17898001 MGI:3761053 NCBI chrNW_004936473:6,031,627...6,052,211 JBrowse link
mammary gland bud elongation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pthlh parathyroid hormone like hormone ISO (MGI:1203302|PMID:9477327) MGI PMID:9477327 MGI:1203302 NCBI chrNW_004936760:197,525...209,212 JBrowse link
mammary gland bud formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 ISO (MGI:2155478|PMID:11782400) MGI PMID:11782400 MGI:2155478 NCBI chrNW_004936480:18,114,231...18,195,884 JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 ISO (MGI:2155478|PMID:11782400) MGI PMID:11782400 MGI:2155478 NCBI chrNW_004936486:10,506,680...10,606,272 JBrowse link
mammary gland bud morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sostdc1 sclerostin domain containing 1 ISO (MGI:5319554|PMID:22509524) MGI PMID:22509524 MGI:5319554 NCBI chrNW_004936546:2,976,045...2,980,487 JBrowse link
regulation of branching involved in mammary gland duct morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 ISO (MGI:3830397|PMID:19164602) MGI PMID:19164602 MGI:3830397 NCBI chrNW_004936602:4,264,896...4,278,160 JBrowse link
G Etv5 ETS variant transcription factor 5 ISO (MGI:2667785|PMID:12871699) MGI PMID:12871699 MGI:2667785 NCBI chrNW_004936578:3,795,000...3,854,269 JBrowse link
G Phb2 prohibitin 2 ISO (MGI:3695669|PMID:17065319) MGI PMID:17065319 MGI:3695669 NCBI chrNW_004936709:854,493...859,182 JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO (MGI:3761053|PMID:17898001) MGI PMID:17898001 MGI:3761053 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Wnt5a Wnt family member 5A ISO (MGI:3761053|PMID:17898001) MGI PMID:17898001 MGI:3761053 NCBI chrNW_004936473:6,031,627...6,052,211 JBrowse link
tertiary branching involved in mammary gland duct morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor ISO (MGI:2683859|PMID:14676301) MGI PMID:14676301 MGI:2683859 NCBI chrNW_004936635:485,903...647,820 JBrowse link
G Pgr progesterone receptor ISO (MGI:1354852|PMID:10733525) MGI PMID:10733525 MGI:1354852 NCBI chrNW_004936551:6,498,553...6,573,212 JBrowse link
G Wnt4 Wnt family member 4 ISO (MGI:1354852|PMID:10733525) MGI PMID:10733525 MGI:1354852 NCBI chrNW_004936474:7,623,462...7,635,416 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12002
    developmental process 5648
      anatomical structure morphogenesis 2521
        tube morphogenesis 852
          epithelial tube morphogenesis 380
            mammary gland duct morphogenesis 41
              branching involved in mammary gland duct morphogenesis + 29
              mammary duct terminal end bud growth 7
              mammary gland bud morphogenesis + 4
              mammary gland cord morphogenesis + 0
              mammary gland duct cavitation 0
              mammary gland duct regression in males 0
Path 2
Term Annotations click to browse term
  biological_process 12002
    developmental process 5648
      anatomical structure development 5286
        multicellular organism development 4845
          system development 4567
            animal organ development 3514
              animal organ morphogenesis 1021
                gland morphogenesis 157
                  mammary gland morphogenesis 60
                    mammary gland duct morphogenesis 41
                      branching involved in mammary gland duct morphogenesis + 29
                      mammary duct terminal end bud growth 7
                      mammary gland bud morphogenesis + 4
                      mammary gland cord morphogenesis + 0
                      mammary gland duct cavitation 0
                      mammary gland duct regression in males 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.