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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of response to cytokine stimulus
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Accession:GO:0060759 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus.


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negative regulation of chemokine-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:1600115
G Padi2 peptidyl arginine deiminase 2 JBrowse link 5 159,428,479 159,471,113 RGD:1600115
RGD:1624291
G Rnf113a1 ring finger protein 113A1 JBrowse link X 123,806,922 123,808,049 RGD:1624291
G Robo1 roundabout guidance receptor 1 JBrowse link 11 9,079,291 10,146,302 RGD:1624291
RGD:1600115
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
RGD:1600115
G Slit2 slit guidance ligand 2 JBrowse link 14 66,831,848 67,171,491 RGD:1624291
RGD:1600115
G Slit3 slit guidance ligand 3 JBrowse link 10 19,924,200 20,517,918 RGD:1624291
RGD:1600115
negative regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
RGD:1600115
G Ecm1 extracellular matrix protein 1 JBrowse link 2 197,855,468 197,860,973 RGD:1624291
G Il36rn interleukin 36 receptor antagonist JBrowse link 3 1,385,256 1,392,275 RGD:1624291
G Palm3 paralemmin 3 JBrowse link 19 25,143,464 25,152,275 RGD:1624291
RGD:13792537
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
RGD:1600115
G Ptprf protein tyrosine phosphatase, receptor type, F JBrowse link 5 137,036,936 137,112,930 RGD:1642742
G Sigirr single Ig and TIR domain containing JBrowse link 1 213,898,395 213,907,697 RGD:1624291
RGD:1600115
negative regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg1 arginase 1 JBrowse link 1 21,525,421 21,537,872 RGD:1624291
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 10 11,059,701 11,085,186 RGD:1624291
G Otop1 otopetrin 1 JBrowse link 14 77,236,278 77,263,729 RGD:1600115
RGD:1624291
G Parp14 poly (ADP-ribose) polymerase family, member 14 JBrowse link 11 68,105,442 68,137,509 RGD:1624291
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:1624291
RGD:1600115
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:1600115
RGD:13792537
RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
G Otud4 OTU deubiquitinase 4 JBrowse link 19 31,895,753 31,942,509 RGD:1624291
RGD:13792537
negative regulation of interleukin-2-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of Kit signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rabgef1 RAB guanine nucleotide exchange factor 1 JBrowse link 12 29,960,132 30,004,727 RGD:1624291
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
RGD:1600115
negative regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Stap1 signal transducing adaptor family member 1 JBrowse link 14 23,575,400 23,604,984 RGD:1624291
negative regulation of response to cytokine stimulus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:1624291
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:8553940
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:1624291
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
G Tle5 TLE family member 5, transcriptional modulator JBrowse link 7 11,012,843 11,018,156 RGD:1624291
RGD:1600115
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1624291
RGD:1600115
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
G Ccdc3 coiled-coil domain containing 3 JBrowse link 17 76,991,722 77,093,515 RGD:1624291
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Gps2 G protein pathway suppressor 2 JBrowse link 10 56,524,327 56,527,447 RGD:1624291
G Hist2h2be histone cluster 2 H2B family member E JBrowse link 2 198,360,837 198,363,399 RGD:1624291
G Nlrp1b NLR family, pyrin domain containing 1B JBrowse link 10 57,755,957 57,847,867 RGD:1624291
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:1600115
RGD:1624291
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:1600115
RGD:1624291
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 1 220,191,209 220,204,032 RGD:1624291
G Pias4 protein inhibitor of activated STAT, 4 JBrowse link 7 11,414,565 11,428,090 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase JBrowse link 10 70,157,621 70,220,618 RGD:1624291
RGD:1600115
G Traip TRAF-interacting protein JBrowse link 8 116,730,170 116,750,528 RGD:1624291
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adar adenosine deaminase, RNA-specific JBrowse link 2 189,045,551 189,085,448 RGD:1624291
RGD:1600115
G Cactin cactin, spliceosome C complex subunit JBrowse link 7 11,258,526 11,266,509 RGD:1624291
G Cnot7 CCR4-NOT transcription complex, subunit 7 JBrowse link 16 54,899,452 54,918,616 RGD:1624291
G Dcst1 DC-STAMP domain containing 1 JBrowse link 2 188,672,549 188,690,004 RGD:1624291
G Mettl3 methyltransferase-like 3 JBrowse link 15 28,710,299 28,721,491 RGD:1624291
G Mmp12 matrix metallopeptidase 12 JBrowse link 8 5,594,717 5,616,494 RGD:1600115
RGD:1624291
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 5 156,855,105 156,864,517 RGD:1624291
G Nlrc5 NLR family, CARD domain containing 5 JBrowse link 19 10,904,381 11,006,202 RGD:1624291
RGD:13792537
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 JBrowse link 3 153,210,829 153,250,705 RGD:1624291
G Trex1 three prime repair exonuclease 1 JBrowse link 8 117,796,127 117,797,427 RGD:1624291
G Ttll12 tubulin tyrosine ligase like 12 JBrowse link 7 124,472,758 124,491,004 RGD:1624291
G Ythdf2 YTH N(6)-methyladenosine RNA binding protein 2 JBrowse link 5 150,364,490 150,390,173 RGD:1624291
G Ythdf3 YTH N(6)-methyladenosine RNA binding protein 3 JBrowse link 2 100,677,388 100,711,365 RGD:1624291
positive regulation of C-C chemokine receptor CCR7 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
positive regulation of cellular response to macrophage colony-stimulating factor stimulus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
positive regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:1624291
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
RGD:13792537
RGD:1600115
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Il7 interleukin 7 JBrowse link 2 96,427,884 96,474,979 RGD:1600115
RGD:1624291
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 JBrowse link 10 61,456,144 61,577,412 RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G Trim44 tripartite motif-containing 44 JBrowse link 3 91,968,781 92,242,138 RGD:1600115
RGD:1624291
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:1624291
positive regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hpx hemopexin JBrowse link 1 170,423,558 170,431,066 RGD:1624291
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:1624291
G Med1 mediator complex subunit 1 JBrowse link 10 86,101,560 86,145,271 RGD:1624291
G Nlrc5 NLR family, CARD domain containing 5 JBrowse link 19 10,904,381 11,006,202 RGD:1624291
G Parp9 poly (ADP-ribose) polymerase family, member 9 JBrowse link 11 67,724,071 67,758,027 RGD:1624291
RGD:13792537
G Txk TXK tyrosine kinase JBrowse link 14 38,029,809 38,085,822 RGD:1624291
positive regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:1624291
RGD:1600115
positive regulation of interleukin-17-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trim32 tripartite motif-containing 32 JBrowse link 5 81,431,554 81,449,023 RGD:1624291
positive regulation of interleukin-18-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 40,555,106 40,572,569 RGD:1624291
positive regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd300lf Cd300 molecule-like family member F JBrowse link 10 103,669,781 103,690,584 RGD:1624291
RGD:1600115
G Parp14 poly (ADP-ribose) polymerase family, member 14 JBrowse link 11 68,105,442 68,137,509 RGD:1624291
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qtnf4 C1q and TNF related 4 JBrowse link 3 79,713,580 79,718,018 RGD:1624291
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link 14 3,058,035 3,073,332 RGD:1624291
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:1624291
positive regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Csf1 colony stimulating factor 1 JBrowse link 2 210,522,370 210,550,546 RGD:1624291
RGD:1600115
positive regulation of macrophage migration inhibitory factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:1624291
positive regulation of prolactin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crebrf CREB3 regulatory factor JBrowse link 10 16,693,846 16,753,162 RGD:1624291
positive regulation of response to cytokine stimulus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddx58 DEXD/H-box helicase 58 JBrowse link 5 56,486,584 56,536,898 RGD:1624291
G Dhx9 DExH-box helicase 9 JBrowse link 13 70,885,503 70,922,278 RGD:1624291
G Ifih1 interferon induced with helicase C domain 1 JBrowse link 3 48,557,696 48,604,097 RGD:1624291
G Mavs mitochondrial antiviral signaling protein JBrowse link 3 123,776,147 123,790,572 RGD:1624291
RGD:1600115
G Taf9 TATA-box binding protein associated factor 9 JBrowse link 2 30,664,407 30,668,414 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
positive regulation of response to interferon-gamma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hpx hemopexin JBrowse link 1 170,423,558 170,431,066 RGD:1624291
positive regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:1624291
RGD:1600115
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:1624291
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:1624291
G Cpne1 copine 1 JBrowse link 3
3
151,617,733
152,150,143
151,625,448
152,192,936
RGD:1624291
RGD:13792537
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:1624291
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
RGD:1600115
G Rbm12 RNA binding motif protein 12 JBrowse link 3 151,616,038 151,658,427 RGD:13792537
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:1624291
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:1624291
G Trim32 tripartite motif-containing 32 JBrowse link 5 81,431,554 81,449,023 RGD:1624291
G Ube2k ubiquitin-conjugating enzyme E2K JBrowse link 14 44,289,247 44,348,691 RGD:1624291
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:1624291
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon JBrowse link 13 48,031,325 48,056,394 RGD:1624291
G Irf3 interferon regulatory factor 3 JBrowse link 1 100,992,244 100,997,202 RGD:1624291
G Irf7 interferon regulatory factor 7 JBrowse link 1 214,249,388 214,252,909 RGD:1624291
G Lsm14a LSM14A mRNA processing body assembly factor JBrowse link 1 90,200,866 90,246,292 RGD:1624291
G Mavs mitochondrial antiviral signaling protein JBrowse link 3 123,776,147 123,790,572 RGD:1624291
G Mmp12 matrix metallopeptidase 12 JBrowse link 8 5,594,717 5,616,494 RGD:1600115
RGD:1624291
G Nlrc5 NLR family, CARD domain containing 5 JBrowse link 19 10,904,381 11,006,202 RGD:1624291
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:1624291
G Trim6 tripartite motif containing 6 JBrowse link 1 169,410,084 169,423,305 RGD:1624291
G Ube2k ubiquitin-conjugating enzyme E2K JBrowse link 14 44,289,247 44,348,691 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
G Zbp1 Z-DNA binding protein 1 JBrowse link 3 171,276,062 171,292,062 RGD:1624291
RGD:1600115
RGD:13792537
regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd24 CD24 molecule JBrowse link 20 48,335,540 48,340,847 RGD:1624291
RGD:8553244
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:1624291
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:1624291
regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc37 cell division cycle 37, HSP90 cochaperone JBrowse link 8 22,160,922 22,173,797 RGD:1624291
RGD:1600115
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:1624291
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:1600115
regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vrk2 VRK serine/threonine kinase 2 JBrowse link 14 110,739,835 110,883,836 RGD:1624291
G Zbp1 Z-DNA binding protein 1 JBrowse link 3 171,276,062 171,292,062 RGD:1600115
RGD:1624291
regulation of macrophage migration inhibitory factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Angpt1 angiopoietin 1 JBrowse link 7 81,338,327 81,592,459 RGD:1624291
RGD:1600115
regulation of response to interferon-gamma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Parp9 poly (ADP-ribose) polymerase family, member 9 JBrowse link 11 67,724,071 67,758,027 RGD:1624291
regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1600115
RGD:1624291
G Hipk1 homeodomain interacting protein kinase 1 JBrowse link 2 206,224,015 206,274,910 RGD:1624291
RGD:1600115
G Otulin OTU deubiquitinase with linear linkage specificity JBrowse link 2 80,267,724 80,293,204 RGD:1624291
RGD:13792537
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:1624291
RGD:1600115
G Spata2 spermatogenesis associated 2 JBrowse link 3 164,229,211 164,239,483 RGD:1600115
RGD:13792537
RGD:1624291
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:1624291
RGD:1600115
RGD:14397556
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1624291
RGD:1600115
regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc37 cell division cycle 37, HSP90 cochaperone JBrowse link 8 22,160,922 22,173,797 RGD:1624291
RGD:1600115
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    regulation of biological process 12959
      regulation of response to stimulus 4066
        regulation of response to cytokine stimulus 123
          negative regulation of response to cytokine stimulus + 58
          positive regulation of response to cytokine stimulus + 53
          regulation of cytokine-mediated signaling pathway + 113
          regulation of response to interferon-gamma + 15
          regulation of response to macrophage colony-stimulating factor + 5
Path 2
Term Annotations click to browse term
  biological_process 19858
    response to stimulus 10526
      response to chemical 6306
        response to organic substance 3833
          response to cytokine 1130
            regulation of response to cytokine stimulus 123
              negative regulation of response to cytokine stimulus + 58
              positive regulation of response to cytokine stimulus + 53
              regulation of cytokine-mediated signaling pathway + 113
              regulation of response to interferon-gamma + 15
              regulation of response to macrophage colony-stimulating factor + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.