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ONTOLOGY REPORT - ANNOTATIONS


Term:cell fate commitment involved in formation of primary germ layer
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Accession:GO:0060795 term browser browse the term
Definition:The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.


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cell fate commitment involved in formation of primary germ layer term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pou5f1 POU class 5 homeobox 1 ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
axial mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nodal nodal growth differentiation factor ISO (MGI:2677178|PMID:14511481) RGD PMID:14511481 MGI:2677178 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
BMP signaling pathway involved in mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Etv2 ETS variant transcription factor 2 ISO (MGI:4415813|PMID:18462699) RGD PMID:18462699 MGI:4415813 NCBI chr 1:89,091,239...89,094,570
Ensembl chr 1:89,091,239...89,094,530
JBrowse link
ectodermal cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elf5 E74 like ETS transcription factor 5 ISO MGI:95456 (MGI:5616945|PMID:25446535) RGD PMID:25446535 MGI:5616945 NCBI chr 3:93,333,514...93,374,454
Ensembl chr 3:93,351,619...93,371,656
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor ISO MGI:1335079 (MGI:5616945|PMID:25446535) RGD PMID:25446535 MGI:5616945 NCBI chr11:36,075,709...36,092,495
Ensembl chr11:36,075,709...36,092,495
JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO (MGI:1355046|PMID:10742100) RGD PMID:10742100 MGI:1355046 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
endodermal cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc73 cell division cycle 73 IEA
ISO
ISS
GO_REF:0000107
(MGI:3849235|PMID:19345177)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:19345177 GO_REF:0000024, GO_REF:0000107, MGI:3849235 NCBI chr13:60,403,771...60,496,511
Ensembl chr13:60,403,771...60,496,511
JBrowse link
G Ctnnb1 catenin beta 1 IEA
ISO
GO_REF:0000107
MGI:1858007|MGI:2148567 (MGI:3625553|PMID:12194849)
Ensembl
RGD
PMID:12194849 GO_REF:0000107, MGI:3625553 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component ISO (MGI:3849235|PMID:19345177) RGD PMID:19345177 MGI:3849235 NCBI chr 1:175,839,140...175,869,167
Ensembl chr 1:175,839,108...175,869,165
JBrowse link
G Leo1 LEO1 homolog, Paf1/RNA polymerase II complex component ISS
ISO
GO_REF:0000024
(MGI:3849235|PMID:19345177)
UniProt
RGD
PMID:19345177 GO_REF:0000024, MGI:3849235 NCBI chr 8:82,380,906...82,405,293
Ensembl chr 8:82,380,757...82,405,644
JBrowse link
G Paf1 PAF1 homolog, Paf1/RNA polymerase II complex component ISS
ISO
GO_REF:0000024
(MGI:3849235|PMID:19345177)
UniProt
RGD
PMID:19345177 GO_REF:0000024, MGI:3849235 NCBI chr 1:85,362,421...85,367,999
Ensembl chr 1:85,362,268...85,368,031
JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO (MGI:1355046|PMID:10742100) RGD PMID:10742100 MGI:1355046 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) ISO (MGI:3849235|PMID:19345177) RGD PMID:19345177 MGI:3849235 NCBI chr 3:111,478,350...111,537,941
Ensembl chr 3:111,478,382...111,537,941
JBrowse link
endodermal cell fate determination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 IEA
ISO
GO_REF:0000107
(MGI:4442295|PMID:20308546)
Ensembl
RGD
PMID:20308546 GO_REF:0000107, MGI:4442295 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Sox17 SRY-box transcription factor 17 ISO (MGI:4442295|PMID:20308546) RGD PMID:20308546 MGI:4442295 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
endodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin IBA
ISO
PMID:21873635
MGI:3774028 (MGI:4887279|PMID:21245162)
RGD PMID:21245162, PMID:21873635 MGI:4887279, RGD:13792537 NCBI chr 8:127,144,367...127,152,618
Ensembl chr 8:127,144,903...127,151,493
JBrowse link
G Hnf1b HNF1 homeobox B ISO MGI:1857856 (MGI:3807614|PMID:18635606) RGD PMID:18635606 MGI:3807614 NCBI chr10:71,159,863...71,218,902
Ensembl chr10:71,159,869...71,218,902
JBrowse link
G Nanog Nanog homeobox ISO (PMID:20713518) RGD PMID:20713518 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO (PMID:20713518) RGD PMID:20713518 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Sox2 SRY-box transcription factor 2 ISO (PMID:21245162) RGD PMID:21245162 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
mesodermal cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nanog Nanog homeobox ISO MGI:109452 (MGI:3654744|PMID:16801560) RGD PMID:16801560 MGI:3654744 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO (MGI:1355046|PMID:10742100) RGD PMID:10742100 MGI:1355046 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Smad1 SMAD family member 1 IEA
ISO
GO_REF:0000107
MGI:1919200 (MGI:3654744|PMID:16801560)
Ensembl
RGD
PMID:16801560 GO_REF:0000107, MGI:3654744 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
mesodermal cell fate determination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IEA
ISO
GO_REF:0000107
MGI:1857137 (MGI:76261|PMID:7657163)
Ensembl
RGD
PMID:7657163 GO_REF:0000107, MGI:76261 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 ISO (MGI:3768605|PMID:17785448) RGD PMID:17785448 MGI:3768605 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G Hoxa11 homeobox A11 ISO (MGI:3768605|PMID:17785448) RGD PMID:17785448 MGI:3768605 NCBI chr 4:82,296,888...82,301,419
Ensembl chr 4:82,298,152...82,300,503
Ensembl chr 4:82,298,152...82,300,503
JBrowse link
G Pax2 paired box 2 ISS
ISO
GO_REF:0000024
(MGI:3768605|PMID:17785448)
UniProt
RGD
PMID:17785448 GO_REF:0000024, MGI:3768605 NCBI chr 1:264,493,579...264,585,073
Ensembl chr 1:264,504,591...264,583,329
JBrowse link
G Six2 SIX homeobox 2 ISO (MGI:3768605|PMID:17785448) RGD PMID:17785448 MGI:3768605 NCBI chr 6:8,952,572...8,955,893
Ensembl chr 6:8,952,572...8,956,276
JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd7 frizzled class receptor 7 ISO (PMID:18681827) RGD PMID:18681827 NCBI chr 9:66,305,731...66,308,550
Ensembl chr 9:66,305,731...66,308,550
JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 ISO MGI:98956 (MGI:3711603|PMID:17462603) RGD PMID:17462603 MGI:3711603 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
paraxial mesodermal cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxc2 forkhead box C2 ISO MGI:1857865 (MGI:86990|PMID:9106663) RGD PMID:9106663 MGI:86990 NCBI chr19:53,044,379...53,047,081
Ensembl chr19:53,044,379...53,047,081
JBrowse link
G Wnt3a Wnt family member 3A ISO MGI:1857489 (MGI:86727|PMID:9126297) RGD PMID:9126297 MGI:86727 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A ISO MGI:95522 (MGI:3702797|PMID:16943278) RGD PMID:16943278 MGI:3702797 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IEA
ISO
GO_REF:0000107
MGI:1338938 (MGI:3702797|PMID:16943278)
Ensembl
RGD
PMID:16943278 GO_REF:0000107, MGI:3702797 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure formation involved in morphogenesis 1214
        formation of primary germ layer 128
          cell fate commitment involved in formation of primary germ layer 31
            ectodermal cell fate commitment + 4
            endodermal cell fate commitment + 15
            mesodermal cell fate commitment + 17
            transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          embryo development 1307
            embryonic morphogenesis 690
              gastrulation 208
                formation of primary germ layer 128
                  cell fate commitment involved in formation of primary germ layer 31
                    ectodermal cell fate commitment + 4
                    endodermal cell fate commitment + 15
                    mesodermal cell fate commitment + 17
                    transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.