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ONTOLOGY REPORT - ANNOTATIONS


Term:inactivation of X chromosome by heterochromatin assembly
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Accession:GO:0060820 term browser browse the term
Definition:Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by the mechanism of heterochromatin formation.
Synonyms:exact_synonym: inactivation of X chromosome by heterochromatin formation


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inactivation of X chromosome by heterochromatin assembly term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 ISO (MGI:MGI:5532809|PMID:23754746) UniProtKB PMID:23754746 MGI:MGI:5532809 NCBI chr18:11,479,742...11,627,035
Ensembl chr18:13,785,912...13,933,887
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  biological_process 12527
    cellular process 11621
      cellular component organization or biogenesis 4979
        cellular component organization 4899
          chromatin organization 556
            chromatin remodeling 121
              heterochromatin assembly 43
                inactivation of X chromosome by heterochromatin assembly 1
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Term Annotations click to browse term
  biological_process 12527
    metabolic process 7963
      cellular metabolic process 7311
        cellular aromatic compound metabolic process 3868
          nucleobase-containing compound metabolic process 3692
            nucleic acid metabolic process 3389
              RNA metabolic process 3007
                regulation of RNA metabolic process 2581
                  negative regulation of RNA metabolic process 1208
                    negative regulation of RNA biosynthetic process 1114
                      negative regulation of nucleic acid-templated transcription 1112
                        negative regulation of transcription, DNA-templated 1108
                          chromatin organization involved in negative regulation of transcription 61
                            heterochromatin assembly 43
                              inactivation of X chromosome by heterochromatin assembly 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.