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ONTOLOGY REPORT - ANNOTATIONS


Term:inactivation of X chromosome by DNA methylation
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Accession:GO:0060821 term browser browse the term
Definition:Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by a mechanism of DNA methylation.


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inactivation of X chromosome by DNA methylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt3b DNA methyltransferase 3 beta ISO MGI:MGI:3047834 (MGI:MGI:5532809|PMID:23754746) RGD PMID:23754746 MGI:MGI:5532809 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
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G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 ISO MGI:MGI:3586547 (MGI:MGI:3821390|PMID:18425126) RGD PMID:18425126 MGI:MGI:3821390 NCBI chr 9:119,675,750...119,818,620
Ensembl chr 9:119,676,628...119,818,310
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    regulation of biological process 13073
      regulation of metabolic process 7010
        regulation of macromolecule metabolic process 6495
          regulation of gene expression 4799
            regulation of gene expression, epigenetic 153
              dosage compensation 23
                dosage compensation by inactivation of X chromosome 21
                  inactivation of X chromosome by DNA methylation 2
Path 2
Term Annotations click to browse term
  biological_process 20015
    biological regulation 13760
      regulation of biological process 13073
        regulation of metabolic process 7010
          regulation of macromolecule metabolic process 6495
            regulation of gene expression 4799
              regulation of gene expression, epigenetic 153
                dosage compensation 23
                  dosage compensation by inactivation of X chromosome 21
                    inactivation of X chromosome by DNA methylation 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.