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ONTOLOGY REPORT - ANNOTATIONS


Term:heart formation
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Accession:GO:0060914 term browser browse the term
Definition:The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.
Synonyms:related_synonym: cardiogenesis


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heart formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A ISO MGI:2158343 (MGI:3702797|PMID:16943278) RGD PMID:16943278 MGI:3702797 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Ift88 intraflagellar transport 88 ISO MGI:1859153 (MGI:4361064|PMID:19654211) RGD PMID:19654211 MGI:4361064 NCBI chr15:37,690,417...37,786,855
Ensembl chr15:37,691,345...37,784,924
JBrowse link
G Lemd2 LEM domain nuclear envelope protein 2 ISO (MGI:5640886|PMID:25790465) RGD PMID:25790465 MGI:5640886 NCBI chr20:5,779,742...5,786,213
Ensembl chr20:6,545,083...6,556,350
JBrowse link
BMP signaling pathway involved in heart induction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 ISO
ISS
(PMID:19736317)
GO_REF:0000024
RGD
UniProt
PMID:19736317 GO_REF:0000024 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO
ISS
IEA
(PMID:20702560)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:20702560 GO_REF:0000024, GO_REF:0000107 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
cardioblast anterior-lateral migration term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (PMID:18297060) RGD PMID:18297060 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
cardioblast migration term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO MGI:2182080 (MGI:1339460|PMID:10393122) RGD PMID:10393122 MGI:1339460 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
cardioblast migration to the midline involved in heart field formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:1339460|PMID:10393122) RGD PMID:10393122 MGI:1339460 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
heart field specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 ISO (MGI:5907444|PMID:26295701) RGD PMID:26295701 MGI:5907444 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A ISO (PMID:19736317) RGD PMID:19736317 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
neural crest cell migration involved in heart formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Folr1 folate receptor alpha ISO (MGI:3721767|PMID:17286298) RGD PMID:17286298 MGI:3721767 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
JBrowse link
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 ISO (MGI:4438134|PMID:19620969) RGD PMID:19620969 MGI:4438134 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
positive regulation of cardioblast proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase ISO (PMID:21474815) RGD PMID:21474815 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Wnt11 Wnt family member 11 ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:163,794,136...163,813,756
Ensembl chr 1:163,797,660...163,813,756
JBrowse link
G Wnt5a Wnt family member 5A IEA
ISO
GO_REF:0000107
UniProtKB:P48615 (MGI:5424267|PMID:22569553)
Ensembl
RGD
PMID:22569553 GO_REF:0000107, MGI:5424267 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
positive regulation of Notch signaling pathway involved in heart induction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata5 GATA binding protein 5 ISO (MGI:5286818|PMID:21633169) RGD PMID:21633169 MGI:5286818 NCBI chr 3:175,701,278...175,709,465
Ensembl chr 3:175,701,280...175,709,465
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Robo1 roundabout guidance receptor 1 ISO (MGI:5913048|PMID:25691540) RGD PMID:25691540 MGI:5913048 NCBI chr11:9,079,291...10,146,302
Ensembl chr11:9,642,365...10,143,317
JBrowse link
G Robo2 roundabout guidance receptor 2 ISO (MGI:5913048|PMID:25691540) RGD PMID:25691540 MGI:5913048 NCBI chr11:11,062,866...12,618,793
Ensembl chr11:11,062,790...11,585,765
JBrowse link
positive regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 ISO MGI:102780 (MGI:5002778|PMID:21364285) RGD PMID:21364285 MGI:5002778 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G Gng5 G protein subunit gamma 5 ISO (MGI:5604689|PMID:24599258) RGD PMID:24599258 MGI:5604689 NCBI chr 2:252,359,976...252,368,473
Ensembl chr 2:252,359,976...252,368,473
JBrowse link
G Six1 SIX homeobox 1 ISO MGI:109344 (MGI:5002778|PMID:21364285) RGD PMID:21364285 MGI:5002778 NCBI chr 6:95,929,060...95,934,296
Ensembl chr 6:95,929,060...95,934,296
JBrowse link
G Tbx1 T-box transcription factor 1 ISO (MGI:4943633|PMID:19745164) RGD PMID:19745164 MGI:4943633 NCBI chr11:86,552,022...86,561,647
Ensembl chr11:86,552,022...86,560,969
JBrowse link
G Tbx5 T-box transcription factor 5 IEA
ISO
GO_REF:0000107
MGI:2387851 (MGI:5437816|PMID:22898775)
Ensembl
RGD
PMID:22898775 GO_REF:0000107, MGI:5437816 NCBI chr12:42,059,688...42,148,226
Ensembl chr12:42,097,626...42,148,146
JBrowse link
primary heart field specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mef2c myocyte enhancer factor 2C IEA
ISO
ISS
GO_REF:0000107
(MGI:3830899|PMID:16680724)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:16680724 GO_REF:0000024, GO_REF:0000107, MGI:3830899 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Wnt11 Wnt family member 11 ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:163,794,136...163,813,756
Ensembl chr 1:163,797,660...163,813,756
JBrowse link
G Wnt5a Wnt family member 5A IEA
ISO
GO_REF:0000107
UniProtKB:P48615 (MGI:5424267|PMID:22569553)
Ensembl
RGD
PMID:22569553 GO_REF:0000107, MGI:5424267 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
regulation of cardioblast proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 IMP RGD PMID:18824567 RGD:2325311 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
regulation of heart induction by regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pou5f1 POU class 5 homeobox 1 ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 IEA
ISO
GO_REF:0000107
(MGI:4438134|PMID:19620969)
Ensembl
RGD
PMID:19620969 GO_REF:0000107, MGI:4438134 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 IEA
ISO
GO_REF:0000107
(MGI:4413411|PMID:19008477)
Ensembl
RGD
PMID:19008477 GO_REF:0000107, MGI:4413411 NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
JBrowse link
G Hes1 hes family bHLH transcription factor 1 IEA
ISO
GO_REF:0000107
(MGI:4354447|PMID:19609448)
Ensembl
RGD
PMID:19609448 GO_REF:0000107, MGI:4354447 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Isl1 ISL LIM homeobox 1 ISO MGI:2447758 (MGI:4438134|PMID:19620969) RGD PMID:19620969 MGI:4438134 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
secondary heart field specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axin2 axin 2 IEA
ISO
GO_REF:0000107
MGI:96522 (MGI:5432296|PMID:22711842)
Ensembl
RGD
PMID:22711842 GO_REF:0000107, MGI:5432296 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO
ISS
IEA
(PMID:20702560)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:20702560 GO_REF:0000024, GO_REF:0000107 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Foxh1 forkhead box H1 ISO (MGI:3055632|PMID:15363409) RGD PMID:15363409 MGI:3055632 NCBI chr 7:117,730,307...117,733,076
Ensembl chr 7:117,730,307...117,732,387
JBrowse link
G Isl1 ISL LIM homeobox 1 ISO (PMID:20520780) RGD PMID:20520780 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Lrp2 LDL receptor related protein 2 IEA
ISO
ISS
GO_REF:0000107
(MGI:5770180|PMID:26822476)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:26822476 GO_REF:0000024, GO_REF:0000107, MGI:5770180 NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
JBrowse link
G Mef2c myocyte enhancer factor 2C IEA
ISO
ISS
GO_REF:0000107
(MGI:3578591|PMID:15890826)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:15890826 GO_REF:0000024, GO_REF:0000107, MGI:3578591 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO MGI:1270862|MGI:3583755 (MGI:5432296|PMID:22711842) RGD PMID:22711842 MGI:5432296 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 ISO MGI:2148567 (MGI:3828346|PMID:17519332) RGD PMID:17519332 MGI:3828346 NCBI chr 4:7,076,710...7,108,334
Ensembl chr 4:7,076,759...7,108,328
JBrowse link
G Wnt11 Wnt family member 11 ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:163,794,136...163,813,756
Ensembl chr 1:163,797,660...163,813,756
JBrowse link
G Wnt5a Wnt family member 5A IEA
ISO
GO_REF:0000107
UniProtKB:P48615 (MGI:5424267|PMID:22569553)
Ensembl
RGD
PMID:22569553 GO_REF:0000107, MGI:5424267 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mks1 MKS transition zone complex subunit 1 IEA
ISO
GO_REF:0000107
MGI:4821832 (MGI:5811184|PMID:27340223)
Ensembl
RGD
PMID:27340223 GO_REF:0000107, MGI:5811184 NCBI chr10:75,149,814...75,160,481
Ensembl chr10:75,149,814...75,160,480
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure formation involved in morphogenesis 1214
        animal organ formation 76
          heart formation 34
            cardioblast proliferation + 12
            cell migration involved in heart formation + 2
            heart field specification + 19
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            animal organ development 4033
              heart development 687
                heart morphogenesis 280
                  heart formation 34
                    cardioblast proliferation + 12
                    cell migration involved in heart formation + 2
                    heart field specification + 19
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.