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ONTOLOGY REPORT - ANNOTATIONS


Term:heart formation
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Accession:GO:0060914 term browser browse the term
Definition:The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.
Synonyms:related_synonym: cardiogenesis


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heart formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
RGD:1600115
G Ift88 intraflagellar transport 88 JBrowse link 15 37,690,417 37,786,855 RGD:1624291
G Lemd2 LEM domain containing 2 JBrowse link 20 5,779,742 5,786,213 RGD:1624291
BMP signaling pathway involved in heart induction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
RGD:1600115
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
cardioblast anterior-lateral migration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
RGD:1600115
cardioblast migration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
cardioblast migration to the midline involved in heart field formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
RGD:1600115
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:1624291
RGD:1600115
neural crest cell migration involved in heart formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Folr1 folate receptor alpha JBrowse link 1 166,934,457 166,945,864 RGD:1624291
RGD:1600115
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
RGD:1600115
positive regulation of cardioblast proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 20 8,165,423 8,169,557 RGD:1624291
RGD:1600115
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
RGD:1600115
positive regulation of Notch signaling pathway involved in heart induction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gata5 GATA binding protein 5 JBrowse link 3 175,701,278 175,709,465 RGD:1600115
RGD:1624291
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
RGD:1600115
G Robo1 roundabout guidance receptor 1 JBrowse link 11 9,079,291 10,146,302 RGD:1624291
G Robo2 roundabout guidance receptor 2 JBrowse link 11 11,062,866 12,618,793 RGD:1624291
positive regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:1624291
RGD:1600115
G Gng5 G protein subunit gamma 5 JBrowse link 2 252,359,976 252,368,473 RGD:1624291
G Six1 SIX homeobox 1 JBrowse link 6 95,929,060 95,934,296 RGD:1624291
RGD:1600115
G Tbx1 T-box transcription factor 1 JBrowse link 11 86,552,022 86,561,647 RGD:1624291
G Tbx5 T-box transcription factor 5 JBrowse link 12 42,059,688 42,148,226 RGD:1624291
RGD:1600115
primary heart field specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:1600115
RGD:1624291
regulation of cardioblast proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:2325311
regulation of heart induction by regulation of canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Hand2 heart and neural crest derivatives expressed 2 JBrowse link 16 36,371,489 36,373,551 RGD:1624291
RGD:1600115
G Hes1 hes family bHLH transcription factor 1 JBrowse link 11 74,312,837 74,315,249 RGD:1624291
RGD:1600115
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:1624291
RGD:1600115
secondary heart field specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:1624291
RGD:1600115
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Foxh1 forkhead box H1 JBrowse link 7 117,730,307 117,733,076 RGD:1624291
RGD:1600115
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:1624291
RGD:1600115
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:1600115
RGD:1624291
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:1600115
RGD:1624291
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
RGD:1600115
G Rbpj recombination signal binding protein for immunoglobulin kappa J region JBrowse link 14 59,657,738 59,865,427 RGD:1624291
G Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 JBrowse link 4 7,076,710 7,108,334 RGD:1624291
RGD:1600115
smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mks1 MKS transition zone complex subunit 1 JBrowse link 10 75,149,814 75,160,481 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    developmental process 6539
      anatomical structure formation involved in morphogenesis 1170
        animal organ formation 74
          heart formation 31
            cardioblast proliferation + 12
            cell migration involved in heart formation + 2
            heart field specification + 16
Path 2
Term Annotations click to browse term
  biological_process 18166
    developmental process 6539
      anatomical structure development 6020
        multicellular organism development 5501
          system development 5050
            animal organ development 3862
              heart development 681
                heart morphogenesis 279
                  heart formation 31
                    cardioblast proliferation + 12
                    cell migration involved in heart formation + 2
                    heart field specification + 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.