ONTOLOGY REPORT - ANNOTATIONS


Term:dendritic spine development
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Accession:GO:0060996 term browser browse the term
Definition:The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


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dendritic spine development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acsl4 acyl-CoA synthetase long-chain family member 4 JBrowse link X 113,596,247 113,660,024 RGD:2312805
G Arf4 ADP-ribosylation factor 4 JBrowse link 16 2,338,333 2,354,909 RGD:1624291
RGD:1600115
G Arid1b AT-rich interaction domain 1B JBrowse link 1 45,923,119 46,232,301 RGD:1624291
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:1600115
RGD:1624291
G Ephb1 Eph receptor B1 JBrowse link 8 110,376,954 110,813,193 RGD:10047256
RGD:1600115
RGD:1624291
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:1624291
G Ephb3 Eph receptor B3 JBrowse link 11 83,527,960 83,546,742 RGD:1624291
G Fmr1 fragile X mental retardation 1 JBrowse link X 154,684,924 154,722,369 RGD:1624291
G Git1 GIT ArfGAP 1 JBrowse link 10 62,656,000 62,664,467 RGD:10047256
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:10047256
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:1624291
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 11 72,829,407 72,865,815 RGD:1624291
G Pak3 p21 (RAC1) activated kinase 3 JBrowse link X 114,784,452 115,042,683 RGD:1624291
G Pak4 p21 (RAC1) activated kinase 4 JBrowse link 1 85,162,462 85,201,746 RGD:1624291
RGD:1600115
G Slc12a5 solute carrier family 12 member 5 JBrowse link 3 161,433,303 161,465,078 RGD:10449516
RGD:1624291
RGD:1600115
G Slc9a6 solute carrier family 9 member A6 JBrowse link X 158,979,081 159,045,019 RGD:1624291
RGD:1600115
G Spire1 spire-type actin nucleation factor 1 JBrowse link 18 63,226,557 63,357,420 RGD:1624291
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 JBrowse link 13 48,065,280 48,286,888 RGD:1624291
RGD:1600115
G Uba6 ubiquitin-like modifier activating enzyme 6 JBrowse link 14 23,507,628 23,571,446 RGD:1624291
RGD:1600115
dendritic spine morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:1624291
RGD:1600115
G Ctnnd2 catenin delta 2 JBrowse link 2 83,227,247 84,094,315 RGD:1600115
RGD:13792537
RGD:1624291
G Dlg4 discs large MAGUK scaffold protein 4 JBrowse link 10 56,625,845 56,655,543 RGD:8554095
RGD:1600115
RGD:1624291
G Dock10 dedicator of cytokinesis 10 JBrowse link 9
9
86,424,638
86,312,470
86,571,854
86,423,054
RGD:1624291
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:10449514
G Epha5 EPH receptor A5 JBrowse link 14 25,589,312 25,958,258 RGD:8554330
G Ephb1 Eph receptor B1 JBrowse link 8 110,376,954 110,813,193 RGD:1600115
RGD:1624291
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:1624291
RGD:1600115
G Ephb3 Eph receptor B3 JBrowse link 11 83,527,960 83,546,742 RGD:1624291
RGD:1600115
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Myo5b myosin Vb JBrowse link 18 70,426,865 70,729,985 RGD:11533643
G Pak3 p21 (RAC1) activated kinase 3 JBrowse link X 114,784,452 115,042,683 RGD:1624291
RGD:1600115
G Prmt3 protein arginine methyltransferase 3 JBrowse link 1 105,113,595 105,200,253 RGD:9491824
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
RGD:1600115
G Sept7 septin 7 JBrowse link 8 26,412,910 26,476,615 RGD:1624291
G Shank1 SH3 and multiple ankyrin repeat domains 1 JBrowse link 1 100,297,137 100,344,377 RGD:1624291
RGD:13792537
RGD:1600115
G Shank2 SH3 and multiple ankyrin repeat domains 2 JBrowse link 1 217,149,156 217,593,950 RGD:13792537
G Shank3 SH3 and multiple ankyrin repeat domains 3 JBrowse link 7 130,474,278 130,534,679 RGD:1600115
RGD:13792537
RGD:1624291
G Wasl WASP like actin nucleation promoting factor JBrowse link 4 51,677,722 51,726,212 RGD:1600115
RGD:1624291
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:1624291
RGD:1600115
G Zfp365 zinc finger protein 365 JBrowse link 20 22,060,160 22,083,766 RGD:1624291
RGD:1600115
negative regulation of dendritic spine development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 JBrowse link 7 104,670,076 104,951,090 RGD:1624291
RGD:1600115
G Fstl4 follistatin-like 4 JBrowse link 10 38,104,344 38,532,216 RGD:1624291
RGD:1600115
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:9590265
G Mecp2 methyl CpG binding protein 2 JBrowse link X 156,650,389 156,713,813 RGD:12789709
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:10413901
G Plk2 polo-like kinase 2 JBrowse link 2 41,911,143 41,916,901 RGD:7241135
G Ptprs protein tyrosine phosphatase, receptor type, S JBrowse link 9 10,585,360 10,646,205 RGD:1600115
RGD:1624291
negative regulation of dendritic spine morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnm3 dynamin 3 JBrowse link 13 79,906,711 80,379,967 RGD:8553820
G Dtnbp1 dystrobrevin binding protein 1 JBrowse link 17 20,090,136 20,182,332 RGD:11251757
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:1624291
RGD:1600115
G Ngef neuronal guanine nucleotide exchange factor JBrowse link 9 94,569,286 94,601,852 RGD:1624291
RGD:1600115
G Nlgn1 neuroligin 1 JBrowse link 2 111,057,291 111,973,681 RGD:1624291
RGD:1600115
G Nlgn3 neuroligin 3 JBrowse link X 71,199,390 71,227,460 RGD:1624291
RGD:1600115
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
RGD:1600115
G Ube3a ubiquitin protein ligase E3A JBrowse link 1 116,586,901 116,678,161 RGD:11079590
positive regulation of dendritic spine development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:1600115
G Arf1 ADP-ribosylation factor 1 JBrowse link 10 45,562,700 45,579,214 RGD:8553918
G Camk1 calcium/calmodulin-dependent protein kinase I JBrowse link 4 145,289,300 145,300,146 RGD:1624291
RGD:1600115
G Cdkl5 cyclin-dependent kinase-like 5 JBrowse link X 35,536,396 35,773,204 RGD:12791021
G Cfl1 cofilin 1 JBrowse link 1 220,869,805 220,873,337 RGD:11570400
G Cpeb3 cytoplasmic polyadenylation element binding protein 3 JBrowse link 1 255,660,165 255,842,671 RGD:1624291
G Dlg5 discs large MAGUK scaffold protein 5 JBrowse link 15 120,213 230,312 RGD:1624291
RGD:1600115
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 JBrowse link 1 175,883,362 175,895,510 RGD:10755512
G Fmr1 fragile X mental retardation 1 JBrowse link X 154,684,924 154,722,369 RGD:1624291
RGD:1600115
G Foxo6 forkhead box O6 JBrowse link 5 139,208,153 139,227,288 RGD:1624291
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:5509044
G Hnrnpk heterogeneous nuclear ribonucleoprotein K JBrowse link 17 6,664,730 6,676,753 RGD:10002784
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:5147914
G Itsn1 intersectin 1 JBrowse link 11 31,943,119 32,069,249 RGD:13461864
G Kalrn kalirin, RhoGEF kinase JBrowse link 11 69,484,293 70,025,682 RGD:1624291
G Llph LLP homolog, long-term synaptic facilitation factor JBrowse link 7 65,004,544 65,009,509 RGD:1624291
RGD:1600115
G LOC100911956 protein LLP homolog JBrowse link 6 125,863,966 125,865,098 RGD:1600115
G Lpar1 lysophosphatidic acid receptor 1 JBrowse link 5 75,557,038 75,678,067 RGD:2317707
G Mapk6 mitogen-activated protein kinase 6 JBrowse link 8 82,328,013 82,351,108 RGD:1624291
RGD:1600115
G Mapkapk5 mitogen-activated protein kinase-activated protein kinase 5 JBrowse link 12 40,510,378 40,529,332 RGD:1624291
G Mecp2 methyl CpG binding protein 2 JBrowse link X 156,650,389 156,713,813 RGD:12789443
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:10040994
G Neurl1 neuralized E3 ubiquitin protein ligase 1 JBrowse link 1 266,953,006 267,038,879 RGD:1624291
RGD:1600115
G Nlgn1 neuroligin 1 JBrowse link 2 111,057,291 111,973,681 RGD:8553502
RGD:1624291
RGD:8553420
G Nlgn2 neuroligin 2 JBrowse link 10 56,431,586 56,444,847 RGD:8553420
G Nlgn3 neuroligin 3 JBrowse link X 71,199,390 71,227,460 RGD:8553420
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:7174739
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:1624291
G Palm paralemmin JBrowse link 7 12,708,024 12,721,055 RGD:1624291
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A JBrowse link 4 29,976,485 30,247,371 RGD:1299363
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1624291
RGD:1600115
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1624291
G RGD1563888 similar to DNA segment, Chr 16, ERATO Doi 472, expressed JBrowse link 11 17,073,296 17,120,235 RGD:1624291
RGD:1600115
G Shank1 SH3 and multiple ankyrin repeat domains 1 JBrowse link 1 100,297,137 100,344,377 RGD:8553517
RGD:13792537
G Shank2 SH3 and multiple ankyrin repeat domains 2 JBrowse link 1 217,149,156 217,593,950 RGD:13792537
G Shank3 SH3 and multiple ankyrin repeat domains 3 JBrowse link 7 130,474,278 130,534,679 RGD:1624291
RGD:13792537
RGD:7349315
RGD:1600115
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:11568665
G Zmynd8 zinc finger, MYND-type containing 8 JBrowse link 3 162,480,766 162,594,145 RGD:8554267
positive regulation of dendritic spine morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actr2 actin related protein 2 JBrowse link 14 104,338,486 104,375,840 RGD:11530033
G Actr3 actin related protein 3 JBrowse link 13 41,695,520 41,738,622 RGD:11530033
G Afdn afadin, adherens junction formation factor JBrowse link 1 53,713,873 53,861,918 RGD:13838731
G Baiap2 BAI1-associated protein 2 JBrowse link 10 109,107,326 109,187,458 RGD:9684988
G Bhlhb9 basic helix-loop-helix family member B9 JBrowse link X 106,359,981 106,393,457 RGD:1624291
RGD:1600115
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:8553829
G Caprin1 cell cycle associated protein 1 JBrowse link 3 93,701,830 93,789,580 RGD:1600115
RGD:1624291
G Caprin2 caprin family member 2 JBrowse link 4 183,304,993 183,374,195 RGD:1624291
G Cask calcium/calmodulin dependent serine protein kinase JBrowse link X 9,815,652 10,156,155 RGD:11576294
G Cux2 cut-like homeobox 2 JBrowse link 12 40,016,774 40,221,067 RGD:1624291
RGD:1600115
G Dbn1 drebrin 1 JBrowse link 17 9,679,511 9,693,878 RGD:10398809
RGD:1624291
RGD:1600115
G Dhx36 DEAH-box helicase 36 JBrowse link 2 152,785,844 152,824,549 RGD:13792545
G Dnm1l dynamin 1-like JBrowse link 11 88,830,968 88,882,271 RGD:7800727
G Eef2k eukaryotic elongation factor-2 kinase JBrowse link 1 190,780,211 190,839,926 RGD:10401235
G Itpka inositol-trisphosphate 3-kinase A JBrowse link 3 111,545,007 111,553,605 RGD:8553536
G Kalrn kalirin, RhoGEF kinase JBrowse link 11 69,484,293 70,025,682 RGD:1624291
G Lrp8 LDL receptor related protein 8 JBrowse link 5 127,404,348 127,476,636 RGD:1624291
G Marcks myristoylated alanine rich protein kinase C substrate JBrowse link 20 42,966,140 42,971,838 RGD:9685333
G Mfn1 mitofusin 1 JBrowse link 2 118,929,738 118,971,689 RGD:7800727
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:7800727
G Opa1 OPA1, mitochondrial dynamin like GTPase JBrowse link 11 74,717,600 74,793,902 RGD:7800727
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 JBrowse link 10 61,456,144 61,577,412 RGD:1624291
RGD:1600115
G Pak3 p21 (RAC1) activated kinase 3 JBrowse link X 114,784,452 115,042,683 RGD:7775053
G Reln reelin JBrowse link 4 9,347,533 9,774,257 RGD:1600115
RGD:1624291
G Stau2 staufen double-stranded RNA binding protein 2 JBrowse link 5 2,257,910 2,497,429 RGD:10043163
G Tiam1 T-cell lymphoma invasion and metastasis 1 JBrowse link 11 29,931,083 30,061,173 RGD:10043325
regulation of dendritic spine development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arf6 ADP-ribosylation factor 6 JBrowse link 6 91,697,109 91,698,257 RGD:8554141
RGD:13792537
RGD:1624291
G Cpeb3 cytoplasmic polyadenylation element binding protein 3 JBrowse link 1 255,660,165 255,842,671 RGD:1624291
G Disc1 DISC1 scaffold protein JBrowse link 19 57,818,838 58,069,992 RGD:5509795
G Fmr1 fragile X mental retardation 1 JBrowse link X 154,684,924 154,722,369 RGD:1600115
RGD:13792537
RGD:1624291
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:1624291
RGD:1600115
G Sdk1 sidekick cell adhesion molecule 1 JBrowse link 12 14,445,798 15,443,442 RGD:1624291
regulation of dendritic spine morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abi2 abl-interactor 2 JBrowse link 9 67,234,612 67,284,504 RGD:1624291
G Adam10 ADAM metallopeptidase domain 10 JBrowse link 8 77,107,355 77,237,483 RGD:13703034
G Arc activity-regulated cytoskeleton-associated protein JBrowse link 7 115,907,097 115,911,059 RGD:13210528
G Arhgap33 Rho GTPase activating protein 33 JBrowse link 1 88,977,460 88,990,780 RGD:13508596
G Arhgap44 Rho GTPase activating protein 44 JBrowse link 10 51,501,547 51,669,546 RGD:1600115
RGD:13792537
RGD:1624291
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:1624291
RGD:1600115
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 JBrowse link 10 67,862,054 67,863,255 RGD:1624291
RGD:1600115
G Cfl1 cofilin 1 JBrowse link 1 220,869,805 220,873,337 RGD:1624291
RGD:1600115
G Dnm3 dynamin 3 JBrowse link 13 79,906,711 80,379,967 RGD:8554738
G Epha4 Eph receptor A4 JBrowse link 9 83,111,222 83,253,486 RGD:1624291
RGD:1600115
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:13792537
RGD:1600115
G Lzts3 leucine zipper tumor suppressor family member 3 JBrowse link 3 123,174,444 123,185,649 RGD:13210540
G Nlgn3 neuroligin 3 JBrowse link X 71,199,390 71,227,460 RGD:1624291
RGD:8553412
RGD:1600115
G Pdlim5 PDZ and LIM domain 5 JBrowse link 2 247,815,214 247,989,198 RGD:8554803
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A JBrowse link 4 29,976,485 30,247,371 RGD:10043779
G Shank3 SH3 and multiple ankyrin repeat domains 3 JBrowse link 7 130,474,278 130,534,679 RGD:1624291
RGD:7349315
RGD:1600115
G Sipa1l1 signal-induced proliferation-associated 1 like 1 JBrowse link 6 106,052,212 106,163,249 RGD:8554032
G Srcin1 SRC kinase signaling inhibitor 1 JBrowse link 10 85,460,059 85,517,671 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17896
    developmental process 6323
      anatomical structure development 5930
        dendritic spine development 122
          dendritic spine morphogenesis + 68
          negative regulation of dendritic spine development + 15
          positive regulation of dendritic spine development + 63
          regulation of dendritic spine development + 92
Path 2
Term Annotations click to browse term
  biological_process 17896
    developmental process 6323
      anatomical structure development 5930
        multicellular organism development 5425
          system development 5004
            nervous system development 2550
              neurogenesis 1836
                generation of neurons 1705
                  neuron differentiation 1537
                    neuron development 1250
                      neuron projection development 1104
                        dendrite development 299
                          dendritic spine development 122
                            dendritic spine morphogenesis + 68
                            negative regulation of dendritic spine development + 15
                            positive regulation of dendritic spine development + 63
                            regulation of dendritic spine development + 92
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.