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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cartilage development
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Accession:GO:0061035 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


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regulation of cartilage development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
G Kat2a lysine acetyltransferase 2A JBrowse link 10 88,611,586 88,619,558 RGD:1624291
G Scx scleraxis bHLH transcription factor JBrowse link 7 117,519,075 117,521,093 RGD:1624291
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:1600115
RGD:1624291
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
negative regulation of cartilage development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctsk cathepsin K JBrowse link 2 196,655,469 196,666,447 RGD:1624291
G Frzb frizzled-related protein JBrowse link 3 67,635,604 67,668,772 RGD:1624291
G Idua alpha-L-iduronidase JBrowse link 14 2,041,828 2,056,762 RGD:1624291
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:5128612
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:1624291
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:1624291
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:1624291
negative regulation of chondrocyte development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pthlh parathyroid hormone-like hormone JBrowse link 4 181,663,425 181,674,181 RGD:1624291
G Rflna refilin A JBrowse link 12 37,038,732 37,047,628 RGD:1624291
RGD:13792537
G Rflnb refilin B JBrowse link 10 64,196,103 64,202,380 RGD:1624291
RGD:13792537
negative regulation of chondrocyte differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 JBrowse link 2 61,039,072 61,340,687 RGD:1624291
G Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 JBrowse link 8 97,535,777 97,575,661 RGD:1624291
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Ccn4 cellular communication network factor 4 JBrowse link 7 107,695,227 107,723,759 RGD:1600115
RGD:1624291
G Chadl chondroadherin-like JBrowse link 7 122,915,847 122,929,127 RGD:1624291
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Efemp1 EGF containing fibulin extracellular matrix protein 1 JBrowse link 14 113,202,382 113,294,993 RGD:1600115
RGD:1624291
G Gdf5 growth differentiation factor 5 JBrowse link 3 151,482,672 151,487,129 RGD:1624291
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:1624291
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
G Ltbp3 latent transforming growth factor beta binding protein 3 JBrowse link 1 221,099,155 221,116,096 RGD:1624291
G Nkx3-2 NK3 homeobox 2 JBrowse link 14 73,813,531 73,818,489 RGD:1624291
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:12793028
G Pthlh parathyroid hormone-like hormone JBrowse link 4 181,663,425 181,674,181 RGD:1624291
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:1600115
RGD:1624291
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:1624291
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:1624291
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:1624291
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:1624291
RGD:1600115
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1624291
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:1624291
negative regulation of growth plate cartilage chondrocyte proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dspp dentin sialophosphoprotein JBrowse link 14 6,926,972 6,933,079 RGD:1624291
positive regulation of cartilage development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp1 bone morphogenetic protein 1 JBrowse link 15 52,166,401 52,210,786 RGD:1624291
G Bmp10 bone morphogenetic protein 10 JBrowse link 4 119,224,906 119,230,534 RGD:1600115
RGD:1624291
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
RGD:1600115
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Bmpr2 bone morphogenetic protein receptor type 2 JBrowse link 9 66,568,074 66,683,019 RGD:1600115
G Ccn1 cellular communication network factor 1 JBrowse link 2 251,529,354 251,532,312 RGD:1624291
RGD:1600115
G Gdf2 growth differentiation factor 2 JBrowse link 16 10,267,510 10,293,545 RGD:1624291
G Mdk midkine JBrowse link 3 80,841,003 80,843,895 RGD:1600115
RGD:1624291
G Scx scleraxis bHLH transcription factor JBrowse link 7 117,519,075 117,521,093 RGD:1624291
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:1624291
RGD:1600115
G Sox5 SRY-box transcription factor 5 JBrowse link 4 178,062,267 179,031,991 RGD:1624291
G Sox6 SRY-box transcription factor 6 JBrowse link 1 185,631,702 186,186,192 RGD:1624291
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:1624291
RGD:1600115
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:1624291
RGD:1600115
positive regulation of chondrocyte differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:7242190
G Fgf18 fibroblast growth factor 18 JBrowse link 10 18,047,109 18,082,290 RGD:1624291
RGD:1600115
G Gdf5 growth differentiation factor 5 JBrowse link 3 151,482,672 151,487,129 RGD:1624291
G Gdf6 growth differentiation factor 6 JBrowse link 5 23,056,345 23,072,666 RGD:1624291
RGD:1600115
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
G Hoxa11 homeobox A11 JBrowse link 4 82,296,888 82,301,419 RGD:1624291
G Hoxd11 homeobox D11 JBrowse link 3 61,604,256 61,606,874 RGD:1624291
G Loxl2 lysyl oxidase-like 2 JBrowse link 15 51,276,022 51,365,238 RGD:1600115
RGD:1624291
G Mustn1 musculoskeletal, embryonic nuclear protein 1 JBrowse link 16 6,962,737 6,964,987 RGD:1624291
G Pkdcc protein kinase domain containing, cytoplasmic JBrowse link 6 6,427,657 6,436,974 RGD:1624291
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:2316785
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:2298851
G Runx2 RUNX family transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:1624291
RGD:1600115
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:1624291
G Sox5 SRY-box transcription factor 5 JBrowse link 4 178,062,267 179,031,991 RGD:1624291
RGD:13792537
G Sox6 SRY-box transcription factor 6 JBrowse link 1 185,631,702 186,186,192 RGD:1624291
RGD:13792537
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:1600115
RGD:13792537
RGD:1624291
G Thrb thyroid hormone receptor beta JBrowse link 15 8,890,578 9,239,815 RGD:1601663
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:1624291
RGD:1600115
G Zfp219 zinc finger protein 219 JBrowse link 15 28,402,412 28,417,379 RGD:1624291
positive regulation of chondrocyte hypertrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:1600115
RGD:1624291
regulation of chondrocyte development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:1624291
RGD:1600115
regulation of chondrocyte differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:1624291
G Glg1 golgi glycoprotein 1 JBrowse link 19 42,983,879 43,088,074 RGD:1624291
RGD:1600115
G Hoxa11 homeobox A11 JBrowse link 4 82,296,888 82,301,419 RGD:1624291
G Hoxd11 homeobox D11 JBrowse link 3 61,604,256 61,606,874 RGD:1624291
G Lnpk lunapark, ER junction formation factor JBrowse link 3 61,432,128 61,494,828 RGD:1624291
G Maf MAF bZIP transcription factor JBrowse link 19 48,179,826 48,200,995 RGD:1624291
RGD:1600115
G Mdk midkine JBrowse link 3 80,841,003 80,843,895 RGD:1600115
RGD:1624291
G Pthlh parathyroid hormone-like hormone JBrowse link 4 181,663,425 181,674,181 RGD:13792537
G Shox2 short stature homeobox 2 JBrowse link 2 164,118,175 164,126,783 RGD:1624291
G Six2 SIX homeobox 2 JBrowse link 6 8,952,572 8,955,893 RGD:1624291
G Trps1 transcriptional repressor GATA binding 1 JBrowse link 7 90,085,895 90,320,430 RGD:1624291
RGD:13792537
regulation of growth plate cartilage chondrocyte proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Carm1 coactivator-associated arginine methyltransferase 1 JBrowse link 8 22,577,723 22,622,555 RGD:1624291
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:2316785

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    multicellular organismal process 8952
      regulation of multicellular organismal process 3443
        regulation of multicellular organismal development 2275
          regulation of cartilage development 72
            negative regulation of cartilage development + 31
            positive regulation of cartilage development + 32
            regulation of cartilage condensation + 0
            regulation of chondrocyte differentiation + 51
            regulation of growth plate cartilage chondrocyte proliferation + 3
Path 2
Term Annotations click to browse term
  biological_process 19858
    developmental process 6735
      anatomical structure development 6181
        multicellular organism development 5638
          system development 5212
            skeletal system development 544
              cartilage development 207
                regulation of cartilage development 72
                  negative regulation of cartilage development + 31
                  positive regulation of cartilage development + 32
                  regulation of cartilage condensation + 0
                  regulation of chondrocyte differentiation + 51
                  regulation of growth plate cartilage chondrocyte proliferation + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.