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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cartilage development
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Accession:GO:0061037 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


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negative regulation of cartilage development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctsk cathepsin K JBrowse link 2 196,655,469 196,666,447 RGD:1624291
RGD:1600115
G Frzb frizzled-related protein JBrowse link 3 67,635,604 67,668,772 RGD:1624291
RGD:1600115
G Idua alpha-L-iduronidase JBrowse link 14 2,041,828 2,056,762 RGD:1624291
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:5128612
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:1624291
RGD:1600115
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:1624291
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:1624291
negative regulation of chondrocyte development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pthlh parathyroid hormone-like hormone JBrowse link 4 181,663,425 181,674,181 RGD:1624291
G Rflna refilin A JBrowse link 12 37,038,732 37,047,628 RGD:1624291
RGD:13792537
G Rflnb refilin B JBrowse link 10 64,196,103 64,202,380 RGD:1624291
RGD:13792537
negative regulation of chondrocyte differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 JBrowse link 2 61,039,072 61,340,687 RGD:1624291
RGD:1600115
G Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 JBrowse link 8 97,535,777 97,575,661 RGD:1624291
RGD:1600115
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Ccn4 cellular communication network factor 4 JBrowse link 7 107,695,227 107,723,759 RGD:1600115
RGD:1624291
G Chadl chondroadherin-like JBrowse link 7 122,915,847 122,929,127 RGD:1624291
RGD:1600115
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Efemp1 EGF containing fibulin extracellular matrix protein 1 JBrowse link 14 113,202,382 113,294,993 RGD:1600115
RGD:1624291
G Gdf5 growth differentiation factor 5 JBrowse link 3 151,482,672 151,487,129 RGD:1624291
RGD:1600115
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:1624291
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
RGD:1600115
G Ltbp3 latent transforming growth factor beta binding protein 3 JBrowse link 1 221,099,155 221,116,096 RGD:1624291
RGD:1600115
G Nkx3-2 NK3 homeobox 2 JBrowse link 14 73,813,531 73,818,489 RGD:1624291
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:12793028
G Pthlh parathyroid hormone-like hormone JBrowse link 4 181,663,425 181,674,181 RGD:1624291
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:1624291
RGD:1600115
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:1624291
RGD:1600115
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:1624291
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:1624291
RGD:1600115
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1624291
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:1624291
negative regulation of growth plate cartilage chondrocyte proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dspp dentin sialophosphoprotein JBrowse link 14 6,926,972 6,933,079 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19245
    negative regulation of biological process 5498
      negative regulation of multicellular organismal process 1354
        negative regulation of cartilage development 30
          negative regulation of cartilage condensation 0
          negative regulation of chondrocyte differentiation + 22
          negative regulation of growth plate cartilage chondrocyte proliferation 1
Path 2
Term Annotations click to browse term
  biological_process 19245
    developmental process 6597
      anatomical structure development 6063
        multicellular organism development 5534
          system development 5081
            skeletal system development 549
              cartilage development 220
                regulation of cartilage development 71
                  negative regulation of cartilage development 30
                    negative regulation of cartilage condensation 0
                    negative regulation of chondrocyte differentiation + 22
                    negative regulation of growth plate cartilage chondrocyte proliferation 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.