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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cartilage development
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Accession:GO:0061037 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


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negative regulation of cartilage development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsk cathepsin K ISO MGI:2182131 (MGI:4397742|PMID:19834056) RGD PMID:19834056 MGI:4397742 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Frzb frizzled-related protein ISO MGI:98958 (MGI:3823145|PMID:18991062) RGD PMID:18991062 MGI:3823145 NCBI chr 3:67,635,604...67,668,772
Ensembl chr 3:67,635,607...67,668,772
JBrowse link
G Idua alpha-L-iduronidase ISO MGI:2176236 (MGI:4397742|PMID:19834056) RGD PMID:19834056 MGI:4397742 NCBI chr14:2,041,828...2,056,762
Ensembl chr14:2,042,411...2,056,762
JBrowse link
G Lep leptin IDA RGD PMID:19876764 RGD:5128612 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Nog noggin IEA
ISO
GO_REF:0000107
(MGI:1353721|PMID:10684250)
Ensembl
RGD
PMID:10684250 GO_REF:0000107, MGI:1353721 NCBI chr10:76,811,759...76,813,386
Ensembl chr10:76,811,759...76,813,386
JBrowse link
G Rara retinoic acid receptor, alpha ISO (MGI:1353721|PMID:10684250) RGD PMID:10684250 MGI:1353721 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarb retinoic acid receptor, beta ISO (MGI:1353721|PMID:10684250) RGD PMID:10684250 MGI:1353721 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma ISO (MGI:1353721|PMID:10684250) RGD PMID:10684250 MGI:1353721 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO MGI:1888389 (MGI:5140242|PMID:21780244) RGD PMID:21780244 MGI:5140242 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Wnt9a Wnt family member 9A ISO (MGI:3839710|PMID:19047045) RGD PMID:19047045 MGI:3839710 NCBI chr10:45,659,045...45,686,103
Ensembl chr10:45,659,143...45,681,393
JBrowse link
negative regulation of chondrocyte development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pthlh parathyroid hormone-like hormone ISO (PMID:90087) RGD PMID:90087 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Rflna refilin A IBA
ISO
PMID:21873635
MGI:1923816 (MGI:5570967|PMID:24436304)
RGD PMID:24436304, PMID:21873635 MGI:5570967, RGD:13792537 NCBI chr12:37,038,732...37,047,628
Ensembl chr12:37,038,733...37,047,628
JBrowse link
G Rflnb refilin B IBA
ISO
PMID:21873635
MGI:1920371 (MGI:5570967|PMID:24436304)
RGD PMID:24436304, PMID:21873635 MGI:5570967, RGD:13792537 NCBI chr10:64,196,103...64,202,380
Ensembl chr10:64,196,127...64,202,380
JBrowse link
negative regulation of chondrocyte differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 ISO (PMID:22247065) RGD PMID:22247065 NCBI chr 2:61,039,072...61,340,687
Ensembl chr 2:61,039,053...61,340,697
JBrowse link
G Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 ISO (PMID:22247065) RGD PMID:22247065 NCBI chr 8:97,535,777...97,575,661
Ensembl chr 8:97,535,777...97,575,655
JBrowse link
G Bmp4 bone morphogenetic protein 4 IEA
ISO
GO_REF:0000107
(MGI:3714677|PMID:17481601)
Ensembl
RGD
PMID:17481601 GO_REF:0000107, MGI:3714677 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Ccn4 cellular communication network factor 4 IEA
ISO
GO_REF:0000107
(MGI:6294593|PMID:15331410)
Ensembl
RGD
PMID:15331410 GO_REF:0000107, MGI:6294593 NCBI chr 7:107,695,227...107,723,759
Ensembl chr 7:107,695,215...107,723,772
JBrowse link
G Chadl chondroadherin-like ISO (MGI:5617405|PMID:25451920) RGD PMID:25451920 MGI:5617405 NCBI chr 7:122,915,847...122,929,127
Ensembl chr 7:122,922,022...122,926,336
JBrowse link
G Ctnnb1 catenin beta 1 IEA
ISO
GO_REF:0000107
MGI:2446084 (MGI:3701031|PMID:16818445)
Ensembl
RGD
PMID:16818445 GO_REF:0000107, MGI:3701031 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:20005202)
Ensembl
UniProt
RGD
PMID:20005202 GO_REF:0000024, GO_REF:0000107 NCBI chr14:113,202,382...113,294,993
Ensembl chr14:113,202,419...113,295,014
JBrowse link
G Gdf5 growth differentiation factor 5 ISO (PMID:21976273) RGD PMID:21976273 NCBI chr 3:151,482,672...151,487,129
Ensembl chr 3:151,483,249...151,486,693
JBrowse link
G Gli2 GLI family zinc finger 2 ISO MGI:1857509 (MGI:3709778|PMID:17328886) RGD PMID:17328886 MGI:3709778 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist ISO (PMID:10556075) RGD PMID:10556075 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO MGI:2180017 (MGI:2178869|PMID:11790802) RGD PMID:11790802 MGI:2178869 NCBI chr 1:221,099,155...221,116,096
Ensembl chr 1:221,099,998...221,116,096
JBrowse link
G Nkx3-2 NK3 homeobox 2 ISO (MGI:3617032|PMID:16421188) RGD PMID:16421188 MGI:3617032 NCBI chr14:73,813,531...73,818,489
Ensembl chr14:73,813,528...73,815,757
JBrowse link
G Pth parathyroid hormone IMP PMID:11604398 CAFA PMID:11604398 RGD:12793028 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Pthlh parathyroid hormone-like hormone ISO (PMID:90087)
MGI:2154515|MGI:95728 (MGI:1352921|PMID:8895385), (MGI:3709778|PMID:17328886)
RGD PMID:90087, PMID:8895385, PMID:17328886 MGI:1352921, MGI:3709778 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISS
ISO
GO_REF:0000024
(MGI:6414736|PMID:29644115)
UniProt
RGD
PMID:29644115 GO_REF:0000024, MGI:6414736 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Rarb retinoic acid receptor, beta ISO (MGI:1353721|PMID:10684250) RGD PMID:10684250 MGI:1353721 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma ISO (MGI:1353721|PMID:10684250) RGD PMID:10684250 MGI:1353721 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Snai2 snail family transcriptional repressor 2 ISO (PMID:19756381) RGD PMID:19756381 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Sox9 SRY-box transcription factor 9 ISS
ISO
GO_REF:0000024
MGI:2158693 (MGI:2135696|PMID:11371614)
UniProt
RGD
PMID:11371614 GO_REF:0000024, MGI:2135696 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO (MGI:3848261|PMID:19494318) RGD PMID:19494318 MGI:3848261 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Wnt9a Wnt family member 9A ISO MGI:3701350|MGI:88267 (MGI:3701031|PMID:16818445) RGD PMID:16818445 MGI:3701031 NCBI chr10:45,659,045...45,686,103
Ensembl chr10:45,659,143...45,681,393
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    negative regulation of biological process 5689
      negative regulation of multicellular organismal process 1124
        negative regulation of cartilage development 30
          negative regulation of chondrocyte differentiation + 23
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            skeletal system development 550
              cartilage development 213
                regulation of cartilage development 71
                  negative regulation of cartilage development 30
                    negative regulation of chondrocyte differentiation + 23
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.