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ONTOLOGY REPORT - ANNOTATIONS


Term:canonical Wnt signaling pathway involved in metanephric kidney development
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Accession:GO:0061290 term browser browse the term
Definition:The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Synonyms:exact_synonym: canonical Wnt receptor signaling pathway involved in metanephric kidney development;   canonical Wnt receptor signalling pathway involved in metanephric kidney development;   canonical Wnt-activated signaling pathway involved in metanephric kidney development


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canonical Wnt signaling pathway involved in metanephric kidney development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 ISO
ISS
(MGI:MGI:3822373|PMID:19112489)
GO_REF:0000024
RGD
UniProt
PMID:19112489 GO_REF:0000024, MGI:MGI:3822373 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 ISO (MGI:MGI:5006869|PMID:21523854) RGD PMID:21523854 MGI:MGI:5006869 NCBI chr 3:101,051,960...101,152,119
Ensembl chr 3:101,051,955...101,152,119
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    signaling 7588
      cell-cell signaling 1752
        cell-cell signaling involved in kidney development 2
          Wnt signaling pathway involved in kidney development 2
            canonical Wnt signaling pathway involved in metanephric kidney development 2
              canonical Wnt signaling pathway involved in ureteric bud branching 0
Path 2
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      anatomical structure development 6256
        multicellular organism development 5735
          system development 5272
            urogenital system development 433
              renal system development 383
                kidney development 369
                  cell-cell signaling involved in kidney development 2
                    Wnt signaling pathway involved in kidney development 2
                      canonical Wnt signaling pathway involved in metanephric kidney development 2
                        canonical Wnt signaling pathway involved in ureteric bud branching 0
paths to the root

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