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ONTOLOGY REPORT - ANNOTATIONS


Term:canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
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Accession:GO:0061317 term browser browse the term
Definition:The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Synonyms:exact_synonym: canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment;   canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment;   canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment


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canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:1624291
G Wnt8a Wnt family member 8A JBrowse link 18 27,331,236 27,336,829 RGD:1624291
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rbpj recombination signal binding protein for immunoglobulin kappa J region JBrowse link 14 59,657,738 59,865,427 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    cellular process 18178
      cellular developmental process 4316
        cell fate commitment 287
          muscle cell fate commitment 14
            cardiac muscle cell fate commitment 9
              canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 4
                negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 1
                positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 1
                regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment + 2
Path 2
Term Annotations click to browse term
  biological_process 19439
    developmental process 6673
      anatomical structure development 6138
        multicellular organism development 5605
          system development 5126
            circulatory system development 1213
              heart development 682
                cell surface receptor signaling pathway involved in heart development 27
                  Wnt signaling pathway involved in heart development 14
                    canonical Wnt signaling pathway involved in heart development 6
                      canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 4
                        negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 1
                        positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 1
                        regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment + 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.