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ONTOLOGY REPORT - ANNOTATIONS


Term:cell proliferation involved in heart morphogenesis
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Accession:GO:0061323 term browser browse the term
Definition:The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart.


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canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 ISO
IEA
(MGI:MGI:2446944|PMID:12464179)
GO_REF:0000107
RGD
Ensembl
PMID:12464179 GO_REF:0000107, MGI:MGI:2446944 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Lrp6 LDL receptor related protein 6 ISO MGI:MGI:2156191 (MGI:MGI:4413394|PMID:19705442) RGD PMID:19705442 MGI:MGI:4413394 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
cell proliferation involved in endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfbr2 transforming growth factor, beta receptor 2 NOT ISO (MGI:MGI:4821522|PMID:20652948) RGD PMID:20652948 MGI:MGI:4821522 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
cell proliferation involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hand2 heart and neural crest derivatives expressed 2 ISO
IEA
MGI:MGI:2386570|MGI:MGI:3803647 (MGI:MGI:4453274|PMID:20144608)
GO_REF:0000107
RGD
Ensembl
PMID:20144608 GO_REF:0000107, MGI:MGI:4453274 NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
JBrowse link
G Pitx2 paired-like homeodomain 2 ISO MGI:MGI:1857844|MGI:MGI:2445429 (MGI:MGI:2446944|PMID:12464179), (MGI:MGI:3701739|PMID:16836994) RGD PMID:12464179, PMID:16836994 MGI:MGI:2446944, MGI:MGI:3701739 NCBI chr 2:233,602,732...233,621,059
Ensembl chr 2:233,602,732...233,621,129
JBrowse link
negative regulation of cell proliferation involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO
ISS
IEA
(PMID:20702560)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:20702560 GO_REF:0000024, GO_REF:0000107 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
negative regulation of cell proliferation involved in heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr2 bone morphogenetic protein receptor type 2 ISO (MGI:MGI:3851675|PMID:19409885) RGD PMID:19409885 MGI:MGI:3851675 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494
JBrowse link
G Notch1 notch receptor 1 ISO (MGI:MGI:6158728|PMID:26491108) RGD PMID:26491108 MGI:MGI:6158728 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 ISO (MGI:MGI:4438134|PMID:19620969) RGD PMID:19620969 MGI:MGI:4438134 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
positive regulation of cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase ISO (PMID:21474815) RGD PMID:21474815 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
positive regulation of cell proliferation involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp10 bone morphogenetic protein 10 ISO
IEA
UniProtKB:P31266 (MGI:MGI:3701380|PMID:17336907)
GO_REF:0000107
RGD
Ensembl
PMID:17336907 GO_REF:0000107, MGI:MGI:3701380 NCBI chr 4:119,224,906...119,230,534
Ensembl chr 4:119,225,040...119,230,728
JBrowse link
G Naca nascent polypeptide associated complex subunit alpha ISO (MGI:MGI:4867362|PMID:21071677) RGD PMID:21071677 MGI:MGI:4867362 NCBI chr 7:2,458,283...2,470,674
Ensembl chr 7:2,458,264...2,470,674
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO (MGI:MGI:3701380|PMID:17336907) RGD PMID:17336907 MGI:MGI:3701380 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Sox9 SRY-box transcription factor 9 ISO MGI:MGI:2385468|MGI:MGI:2450311 (MGI:MGI:3709829|PMID:17350610) RGD PMID:17350610 MGI:MGI:3709829 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
positive regulation of cell proliferation involved in heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad4 SMAD family member 4 ISO
IEA
(MGI:MGI:4946551|PMID:21330551)
GO_REF:0000107
RGD
Ensembl
PMID:21330551 GO_REF:0000107, MGI:MGI:4946551 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
positive regulation of cell proliferation involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO
IEA
(MGI:MGI:3039210|PMID:15070745)
GO_REF:0000107
RGD
Ensembl
PMID:15070745 GO_REF:0000107, MGI:MGI:3039210 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
positive regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 ISO MGI:MGI:102780 (MGI:MGI:5002778|PMID:21364285) RGD PMID:21364285 MGI:MGI:5002778 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G Gng5 G protein subunit gamma 5 ISO (MGI:MGI:5604689|PMID:24599258) RGD PMID:24599258 MGI:MGI:5604689 NCBI chr 2:252,359,976...252,368,473
Ensembl chr 2:252,359,976...252,368,473
JBrowse link
G Six1 SIX homeobox 1 ISO MGI:MGI:109344 (MGI:MGI:5002778|PMID:21364285) RGD PMID:21364285 MGI:MGI:5002778 NCBI chr 6:95,929,060...95,934,296
Ensembl chr 6:95,929,060...95,934,296
JBrowse link
G Tbx1 T-box transcription factor 1 ISO (MGI:MGI:4943633|PMID:19745164) RGD PMID:19745164 MGI:MGI:4943633 NCBI chr11:86,552,022...86,561,647
Ensembl chr11:86,552,022...86,560,969
JBrowse link
G Tbx5 T-box transcription factor 5 ISO
IEA
MGI:MGI:2387851 (MGI:MGI:5437816|PMID:22898775)
GO_REF:0000107
RGD
Ensembl
PMID:22898775 GO_REF:0000107, MGI:MGI:5437816 NCBI chr12:42,059,688...42,148,226
Ensembl chr12:42,097,626...42,148,146
JBrowse link
regulation of cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 IMP RGD PMID:18824567 RGD:2325311 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
regulation of cell proliferation involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eng endoglin NOT ISO (MGI:MGI:3721185|PMID:17628518) RGD PMID:17628518 MGI:MGI:3721185 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 ISO
IEA
(MGI:MGI:4438134|PMID:19620969)
GO_REF:0000107
RGD
Ensembl
PMID:19620969 GO_REF:0000107, MGI:MGI:4438134 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 ISO
IEA
(MGI:MGI:4413411|PMID:19008477)
GO_REF:0000107
RGD
Ensembl
PMID:19008477 GO_REF:0000107, MGI:MGI:4413411 NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO
IEA
(MGI:MGI:4354447|PMID:19609448)
GO_REF:0000107
RGD
Ensembl
PMID:19609448 GO_REF:0000107, MGI:MGI:4354447 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Isl1 ISL LIM homeobox 1 ISO MGI:MGI:2447758 (MGI:MGI:4438134|PMID:19620969) RGD PMID:19620969 MGI:MGI:4438134 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mks1 MKS transition zone complex subunit 1 IEA
ISO
GO_REF:0000107
MGI:MGI:4821832 (MGI:MGI:5811184|PMID:27340223)
Ensembl
RGD
PMID:27340223 GO_REF:0000107, MGI:MGI:5811184 NCBI chr10:75,149,814...75,160,481
Ensembl chr10:75,149,814...75,160,480
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cell population proliferation 2155
        cell proliferation involved in heart morphogenesis 23
          cardioblast proliferation + 12
          cell proliferation involved in atrial ventricular junction remodeling 0
          cell proliferation involved in endocardial cushion morphogenesis 1
          cell proliferation involved in heart valve morphogenesis + 3
          cell proliferation involved in outflow tract morphogenesis + 5
          fibroblast proliferation involved in heart morphogenesis 0
          negative regulation of cell proliferation involved in heart morphogenesis + 3
          positive regulation of cell proliferation involved in heart morphogenesis + 7
          regulation of cell proliferation involved in heart morphogenesis + 21
Path 2
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      anatomical structure development 6269
        multicellular organism development 5744
          system development 5280
            circulatory system development 1224
              heart development 687
                heart morphogenesis 280
                  cell proliferation involved in heart morphogenesis 23
                    cardioblast proliferation + 12
                    cell proliferation involved in atrial ventricular junction remodeling 0
                    cell proliferation involved in endocardial cushion morphogenesis 1
                    cell proliferation involved in heart valve morphogenesis + 3
                    cell proliferation involved in outflow tract morphogenesis + 5
                    fibroblast proliferation involved in heart morphogenesis 0
                    negative regulation of cell proliferation involved in heart morphogenesis + 3
                    positive regulation of cell proliferation involved in heart morphogenesis + 7
                    regulation of cell proliferation involved in heart morphogenesis + 21
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.