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ONTOLOGY REPORT - ANNOTATIONS


Term:chaperone-mediated autophagy
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Accession:GO:0061684 term browser browse the term
Definition:The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded.
Synonyms:exact_synonym: CASA;   chaperone-assisted selective autophagy
 related_synonym: CMA
 xref: Wikipedia:Chaperone-mediated_autophagy


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chaperone-mediated autophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:12793031
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:12793031
G Bag3 Bcl2-associated athanogene 3 JBrowse link 1 199,941,258 199,965,191 RGD:12793031
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:10412301
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:10412301
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:10412301
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:1581607
RGD:1624291
G LOC103692716 heat shock protein HSP 90-alpha JBrowse link 6 135,044,833 135,050,417 RGD:10412301
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link 10 15,197,754 15,200,035 RGD:12793031
G Synpo2 synaptopodin 2 JBrowse link 2 227,255,243 227,411,924 RGD:12793031
chaperone-mediated protein transport involved in chaperone-mediated autophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07011951.1 RGD:13792537
G AABR07033324.1 RGD:13792537
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:10412301
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:10412301
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:10412301
RGD:13792537
G LOC103692716 heat shock protein HSP 90-alpha JBrowse link 6 135,044,833 135,050,417 RGD:10412301
G LOC680121 similar to heat shock protein 8 JBrowse link 11 13,499,168 13,501,271 RGD:13792537
negative regulation of chaperone-mediated autophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctsa cathepsin A JBrowse link 3 161,298,750 161,304,627 RGD:1624291
RGD:10412300
RGD:1600115
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:1624291
RGD:1600115
positive regulation of chaperone-mediated autophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Plk3 polo-like kinase 3 JBrowse link 5 135,997,725 136,002,900 RGD:1624291
RGD:1600115
protein targeting to lysosome involved in chaperone-mediated autophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07011951.1 RGD:13792537
G AABR07033324.1 RGD:13792537
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:1624291
RGD:13792537
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:10412301
RGD:13792537
RGD:1600115
RGD:1624291
G LOC680121 similar to heat shock protein 8 JBrowse link 11 13,499,168 13,501,271 RGD:13792537
regulation of chaperone-mediated autophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:10412296
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19245
    cellular process 17125
      process utilizing autophagic mechanism 424
        autophagy 424
          chaperone-mediated autophagy 17
            chaperone-mediated autophagy translocation complex assembly 0
            chaperone-mediated protein transport involved in chaperone-mediated autophagy 7
            negative regulation of chaperone-mediated autophagy 2
            positive regulation of chaperone-mediated autophagy 1
            protein targeting to lysosome involved in chaperone-mediated autophagy 5
            regulation of chaperone-mediated autophagy + 4
Path 2
Term Annotations click to browse term
  biological_process 19245
    metabolic process 11438
      organic substance metabolic process 10836
        macromolecule metabolic process 9317
          protein metabolic process 5943
            protein catabolic process 941
              chaperone-mediated autophagy 17
                chaperone-mediated autophagy translocation complex assembly 0
                chaperone-mediated protein transport involved in chaperone-mediated autophagy 7
                negative regulation of chaperone-mediated autophagy 2
                positive regulation of chaperone-mediated autophagy 1
                protein targeting to lysosome involved in chaperone-mediated autophagy 5
                regulation of chaperone-mediated autophagy + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.