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ONTOLOGY REPORT - ANNOTATIONS


Term:leukotriene signaling pathway
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Accession:GO:0061737 term browser browse the term
Definition:A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-leukotriene interaction and ends with regulation of a downstream cellular process, e.g. transcription.


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leukotriene signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cysltr1 cysteinyl leukotriene receptor 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr  X:77,671,028...77,700,491
Ensembl chr  X:77,674,150...77,700,269
JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr15:54,903,290...54,941,742
Ensembl chr15:54,905,274...54,906,203
JBrowse link
G Ltb4r leukotriene B4 receptor IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr15:34,449,299...34,453,352
Ensembl chr15:34,452,116...34,453,171
JBrowse link
G Ltb4r2 leukotriene B4 receptor 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr15:34,446,478...34,448,220
Ensembl chr15:34,446,878...34,447,954
JBrowse link
G Rgs1 regulator of G-protein signaling 1 ISO
ISS
(PMID:10480894)
GO_REF:0000024
RGD
UniProt
PMID:10480894 GO_REF:0000024 NCBI chr13:61,066,196...61,070,772
Ensembl chr13:61,066,153...61,070,599
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        G protein-coupled receptor signaling pathway 2509
          leukotriene signaling pathway 5
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          signal transduction 7010
            G protein-coupled receptor signaling pathway 2509
              leukotriene signaling pathway 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.