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ONTOLOGY REPORT - ANNOTATIONS


Term:CAMKK-AMPK signaling cascade
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Accession:GO:0061762 term browser browse the term
Definition:A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
Synonyms:related_synonym: stress-activated AMP-activated protein kinase signaling cascade


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CAMKK-AMPK signaling cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 JBrowse link 12 39,253,409 39,302,601 RGD:1624291
RGD:1600115
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:1624291
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:1624291
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:1624291
negative regulation of CAMKK-AMPK signaling cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:11340206
positive regulation of CAMKK-AMPK signaling cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
regulation of CAMKK-AMPK signaling cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:1600115
RGD:1624291
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    signaling 7553
      signal transduction 6968
        calmodulin dependent kinase signaling pathway 10
          CAMKK-AMPK signaling cascade 8
            negative regulation of CAMKK-AMPK signaling cascade 1
            positive regulation of CAMKK-AMPK signaling cascade 1
            regulation of CAMKK-AMPK signaling cascade + 4
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            intracellular signal transduction 2597
              second-messenger-mediated signaling 481
                calcium-mediated signaling 233
                  CAMKK-AMPK signaling cascade 8
                    negative regulation of CAMKK-AMPK signaling cascade 1
                    positive regulation of CAMKK-AMPK signaling cascade 1
                    regulation of CAMKK-AMPK signaling cascade + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.