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ONTOLOGY REPORT - ANNOTATIONS


Term:telomeric D-loop disassembly
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Accession:GO:0061820 term browser browse the term
Definition:A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus.


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telomeric D-loop disassembly term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blm BLM RecQ like helicase ISO (PMID:19734539) RGD PMID:19734539 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588
JBrowse link
G Pot1 protection of telomeres 1 ISO UniProtKB:O94761 (PMID:22039056) RGD PMID:22039056 NCBI chr 4:51,888,632...51,946,764
Ensembl chr 4:51,888,634...51,946,715
JBrowse link
G Recql4 RecQ like helicase 4 ISO UniProtKB:P54274|UniProtKB:Q14191|UniProtKB:Q15554|UniProtKB:Q9NUX5 (PMID:22039056) RGD PMID:22039056 NCBI chr 7:117,765,892...117,773,128
Ensembl chr 7:117,763,783...117,773,134
JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit ISO (PMID:24012755) RGD PMID:24012755 NCBI chr 1:198,114,514...198,120,061
Ensembl chr 1:198,112,245...198,120,061
JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit ISO (PMID:24012755) RGD PMID:24012755 NCBI chr10:11,787,756...11,808,326
Ensembl chr10:11,786,121...11,807,928
JBrowse link
G Terf1 telomeric repeat binding factor 1 ISO UniProtKB:O94761 (PMID:22039056) RGD PMID:22039056 NCBI chr 5:2,853,455...2,882,731
Ensembl chr 5:2,853,459...2,882,668
JBrowse link
G Terf2 telomeric repeat binding factor 2 ISO
IBA
UniProtKB:O94761 (PMID:22039056)
PMID:21873635
RGD PMID:22039056, PMID:21873635 RGD:13792537 NCBI chr19:39,271,992...39,301,506
Ensembl chr19:39,272,499...39,300,893
JBrowse link
G Wrn WRN RecQ like helicase ISO UniProtKB:O94761 (PMID:15200954), (PMID:19734539), (PMID:22039056), (PMID:26420422) RGD PMID:15200954, PMID:19734539, PMID:22039056, PMID:26420422 NCBI chr16:62,483,773...62,619,018
Ensembl chr16:62,483,761...62,615,375
JBrowse link
negative regulation of telomeric D-loop disassembly term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terf1 telomeric repeat binding factor 1 ISO
IBA
(PMID:15200954)
PMID:21873635
RGD PMID:15200954, PMID:21873635 RGD:13792537 NCBI chr 5:2,853,455...2,882,731
Ensembl chr 5:2,853,459...2,882,668
JBrowse link
G Terf2 telomeric repeat binding factor 2 ISO
IBA
(PMID:15200954)
PMID:21873635
RGD PMID:15200954, PMID:21873635 RGD:13792537 NCBI chr19:39,271,992...39,301,506
Ensembl chr19:39,272,499...39,300,893
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological quality 4284
        homeostatic process 2090
          anatomical structure homeostasis 460
            telomere maintenance 127
              telomeric loop disassembly 9
                telomeric D-loop disassembly 8
                  negative regulation of telomeric D-loop disassembly 2
                  positive regulation of telomeric D-loop disassembly 0
                  regulation of telomeric D-loop disassembly + 2
Path 2
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      cellular metabolic process 11065
        cellular nitrogen compound metabolic process 6683
          nucleobase-containing compound metabolic process 5483
            nucleic acid metabolic process 4980
              DNA metabolic process 919
                telomere maintenance 127
                  telomeric loop disassembly 9
                    telomeric D-loop disassembly 8
                      negative regulation of telomeric D-loop disassembly 2
                      positive regulation of telomeric D-loop disassembly 0
                      regulation of telomeric D-loop disassembly + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.